Imperial College London
Alternate

ProfessorPeterSever

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Pharmacology & Therapeutics
 
 
 
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Contact

 

+44 (0)20 7594 1099p.sever

 
 
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Assistant

 

Mrs Yvonne Green +44 (0)20 7594 1100

 
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Location

 

333ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sung:2019:hmg/ddz070,
author = {Sung, YJ and de, Las Fuentes L and Winkler, TW and Chasman, DI and Bentley, AR and Kraja, AT and Ntalla, I and Warren, HR and Guo, X and Schwander, K and Manning, AK and Brown, MR and Aschard, H and Feitosa, MF and Franceschini, N and Lu, Y and Cheng, C-Y and Sim, X and Vojinovic, D and Marten, J and Musani, SK and Kilpeläinen, TO and Richard, MA and Aslibekyan, S and Bartz, TM and Dorajoo, R and Li, C and Liu, Y and Rankinen, T and Smith, AV and Tajuddin, SM and Tayo, BO and Zhao, W and Zhou, Y and Matoba, N and Sofer, T and Alver, M and Amini, M and Boissel, M and Chai, JF and Chen, X and Divers, J and Gandin, I and Gao, C and Giulianini, F and Goel, A and Harris, SE and Hartwig, FP and He, M and Horimoto, ARVR and Hsu, F-C and Jackson, AU and Kammerer, CM and Kasturiratne, A and Komulainen, P and Kühnel, B and Leander, K and Lee, W-J and Lin, K-H and Luan, J and Lyytikäinen, L-P and McKenzie, CA and Nelson, CP and Noordam, R and Scott, RA and Sheu, WHH and Stanáková, A and Takeuchi,},
doi = {hmg/ddz070},
journal = {Human Molecular Genetics},
pages = {2615--2633},
title = {A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure},
url = {http://dx.doi.org/10.1093/hmg/ddz070},
volume = {28},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
AU  - Sung,YJ
AU  - de,Las Fuentes L
AU  - Winkler,TW
AU  - Chasman,DI
AU  - Bentley,AR
AU  - Kraja,AT
AU  - Ntalla,I
AU  - Warren,HR
AU  - Guo,X
AU  - Schwander,K
AU  - Manning,AK
AU  - Brown,MR
AU  - Aschard,H
AU  - Feitosa,MF
AU  - Franceschini,N
AU  - Lu,Y
AU  - Cheng,C-Y
AU  - Sim,X
AU  - Vojinovic,D
AU  - Marten,J
AU  - Musani,SK
AU  - Kilpeläinen,TO
AU  - Richard,MA
AU  - Aslibekyan,S
AU  - Bartz,TM
AU  - Dorajoo,R
AU  - Li,C
AU  - Liu,Y
AU  - Rankinen,T
AU  - Smith,AV
AU  - Tajuddin,SM
AU  - Tayo,BO
AU  - Zhao,W
AU  - Zhou,Y
AU  - Matoba,N
AU  - Sofer,T
AU  - Alver,M
AU  - Amini,M
AU  - Boissel,M
AU  - Chai,JF
AU  - Chen,X
AU  - Divers,J
AU  - Gandin,I
AU  - Gao,C
AU  - Giulianini,F
AU  - Goel,A
AU  - Harris,SE
AU  - Hartwig,FP
AU  - He,M
AU  - Horimoto,ARVR
AU  - Hsu,F-C
AU  - Jackson,AU
AU  - Kammerer,CM
AU  - Kasturiratne,A
AU  - Komulainen,P
AU  - Kühnel,B
AU  - Leander,K
AU  - Lee,W-J
AU  - Lin,K-H
AU  - Luan,J
AU  - Lyytikäinen,L-P
AU  - McKenzie,CA
AU  - Nelson,CP
AU  - Noordam,R
AU  - Scott,RA
AU  - Sheu,WHH
AU  - Stanáková,A
AU  - Takeuchi,F
AU  - van,der Most PJ
AU  - Varga,TV
AU  - Waken,RJ
AU  - Wang,H
AU  - Wang,Y
AU  - Ware,EB
AU  - Weiss,S
AU  - Wen,W
AU  - Yanek,LR
AU  - Zhang,W
AU  - Zhao,JH
AU  - Afaq,S
AU  - Alfred,T
AU  - Amin,N
AU  - Arking,DE
AU  - Aung,T
AU  - Barr,RG
AU  - Bielak,LF
AU  - Boerwinkle,E
AU  - Bottinger,EP
AU  - Braund,PS
AU  - Brody,JA
AU  - Broeckel,U
AU  - Cade,B
AU  - Campbell,A
AU  - Canouil,M
AU  - Chakravarti,A
AU  - Cocca,M
AU  - Collins,FS
AU  - Connell,JM
AU  - de,Mutsert R
AU  - de,Silva HJ
AU  - Dörr,M
AU  - Duan,Q
AU  - Eaton,CB
AU  - Ehret,G
AU  - Evangelou,E
AU  - Faul,JD
AU  - Forouhi,NG
AU  - Franco,OH
AU  - Friedlander,Y
AU  - Gao,H
AU  - Gigante,B
AU  - Gu,CC
AU  - Gupta,P
AU  - Hagenaars,SP
AU  - Harris,TB
AU  - He,J
AU  - Heikkinen,S
AU  - Heng,C-K
AU  - Hofman,A
AU  - Howard,BV
AU  - Hunt,SC
AU  - Irvin,MR
AU  - Jia,Y
AU  - Katsuya,T
AU  - Kaufman,J
AU  - Kerrison,ND
AU  - Khor,CC
AU  - Koh,W-P
AU  - Koistinen,HA
AU  - Kooperberg,CB
AU  - Krieger,JE
AU  - Kubo,M
AU  - Kutalik,Z
AU  - Kuusisto,J
AU  - Lakka,TA
AU  - Langefeld,CD
AU  - Langenberg,C
AU  - Launer,LJ
AU  - Lee,JH
AU  - Lehne,B
AU  - Levy,D
AU  - Lewis,CE
AU  - Li,Y
AU  - Lifelines,Cohort Study
AU  - Lim,SH
AU  - Liu,C-T
AU  - Liu,J
AU  - Liu,J
AU  - Liu,Y
AU  - Loh,M
AU  - Lohman,KK
AU  - Louie,T
AU  - Mägi,R
AU  - Matsuda,K
AU  - Meitinger,T
AU  - Metspalu,A
AU  - Milani,L
AU  - Momozawa,Y
AU  - Mosley,TH
AU  - Nalls,MA
AU  - Nasri,U
AU  - O'Connell,JR
AU  - Ogunniyi,A
AU  - Palmas,WR
AU  - Palmer,ND
AU  - Pankow,JS
AU  - Pedersen,NL
AU  - Peters,A
AU  - Peyser,PA
AU  - Polasek,O
AU  - Porteous,D
AU  - Raitakari,OT
AU  - Renström,F
AU  - Rice,TK
AU  - Ridker,PM
AU  - Robino,A
AU  - Robinson,JG
AU  - Rose,LM
AU  - Rudan,I
AU  - Sabanayagam,C
AU  - Salako,BL
AU  - Sandow,K
AU  - Schmidt,CO
AU  - Schreiner,PJ
AU  - Scott,WR
AU  - Sever,P
AU  - Sims,M
AU  - Sit
DO  - hmg/ddz070
EP  - 2633
PY  - 2019///
SN  - 0964-6906
SP  - 2615
TI  - A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
T2  - Human Molecular Genetics
UR  - http://dx.doi.org/10.1093/hmg/ddz070
UR  - https://academic.oup.com/hmg/article/28/15/2615/5439584
UR  - http://hdl.handle.net/10044/1/70670
VL  - 28
ER  -
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