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@article{Hughes:2018:10.1002/ejp.1238,
author = {Hughes, SW and Ali, M and Sharma, P and Insan, N and Strutton, PH},
doi = {10.1002/ejp.1238},
journal = {European Journal of Pain},
pages = {1494--1501},
title = {Frequency-dependent top-down modulation of temporal summation by anodal transcranial direct-current stimulation of the primary motor cortex in healthy adults},
url = {http://dx.doi.org/10.1002/ejp.1238},
volume = {22},
year = {2018}
}

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TY  - JOUR
AB  - BackgroundTranscranial directcurrent stimulation (tDCS) applied over the primary motor cortex has been shown to be effective in the treatment of a number of chronic pain conditions. However, there is a lack of understanding of the topdown analgesic mechanisms involved.MethodIn this study, we investigated the effects of tDCS on the facilitation of subjective sensory and pain scores using a transcutaneous electrically evoked measure of temporal summation. In this randomized, blinded, crossover study healthy subjects received a single stimulus given at 0.9× pain threshold (pTh) over the L5 dermatome on the lateral aspect of the right leg, followed by a train of 5 stimuli given at 0.5, 1, 5 and 20 Hz before and after 20 min of sham or anodal tDCS (2 mA) applied over the primary motor cortex. Ratings of sensation and pain intensity were scored on a visual analogue scale (VAS).ResultsTemporal summation leading to pain only occurred at higher frequencies (5 and 20 Hz). Sham or real tDCS had no effect over temporal summation evoked at 5 Hz; however, there was a significant analgesic effect at 20 Hz. Sham or real tDCS had no effect over acute, single stimulievoked responses.ConclusionThese results indicate that anodal tDCS applied to the primary motor cortex preferentially modulates temporal summation induced by highfrequency electrical stimulationinduced pain. The inhibitory effects of tDCS appear to be dynamic and dependent on the degree of spinal cord excitability and may explain the higher analgesic efficacy in patients with moderate to severe chronic pain symptoms.SignificanceThe analgesic effects of tDCS are dependent on spinal cord excitability. This work provides insight into topdown modulation during acute pain and temporal summation. This knowledge may explain why tDCS has a higher analgesic efficacy in chronic pain patients.
AU  - Hughes,SW
AU  - Ali,M
AU  - Sharma,P
AU  - Insan,N
AU  - Strutton,PH
DO  - 10.1002/ejp.1238
EP  - 1501
PY  - 2018///
SN  - 1090-3801
SP  - 1494
TI  - Frequency-dependent top-down modulation of temporal summation by anodal transcranial direct-current stimulation of the primary motor cortex in healthy adults
T2  - European Journal of Pain
UR  - http://dx.doi.org/10.1002/ejp.1238
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441435800012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/ejp.1238
UR  - http://hdl.handle.net/10044/1/81141
VL  - 22
ER  -

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