Imperial College London
Portrait Picture

DrPaulStrutton

Faculty of Medicine, Department of Surgery & Cancer

Reader in Human Neurophysiology
 
 
 
//

Contact

 

+44 (0)20 7594 3239p.strutton

 
 
//

Location

 

205Sir Michael Uren HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hughes:2020:10.1002/ejp.1557,
author = {Hughes, SW and Ward, G and Strutton, PH},
doi = {10.1002/ejp.1557},
journal = {European Journal of Pain},
pages = {1130--1137},
title = {Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin-induced dynamic mechanical allodynia and mechanical pain sensitivity in humans.},
url = {http://dx.doi.org/10.1002/ejp.1557},
volume = {24},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Anodal transcranial direct current stimulation over the primary cortex has been shown to activate regions of the brain involved in the descending modulation of pain sensitivity. However, more research is required in order to dissect the spinal cord analgesic mechanisms associated with the development of central sensitisation. METHODS: In this randomised, double blind, cross over study 12 healthy participants had baseline mechanical stimulus response (S/R) functions measured before and after the development of capsaicin-induced ongoing pain sensitivity. The effects of 20 min of either real or sham transcranial direct current stimulation (tDCS, 2 mA) over the primary motor cortex on dynamic mechanical allodynia (DMA) and mechanical pain sensitivity (MPS) was then investigated. RESULTS: Topical application of capsaicin resulted in an increase in area under the pain ratings curve for both DMA (p < .01) and MPS (p < .01). The effects of tDCS on the area under the curve ratio (i.e. post/pre-treatment) revealed significant analgesic effects over DMA (p < .05) and MPS (p < .05) when compared to sham. CONCLUSIONS: This study demonstrates that anodal tDCS over the primary motor cortex can reduce both dynamic and static forms of mechanical pain sensitivity associated with the development of DMA and MPS, respectively. The use of tDCS may provide a novel mechanism-driven therapy in chronic pain patients with altered mechanical S/R functions.
AU  - Hughes,SW
AU  - Ward,G
AU  - Strutton,PH
DO  - 10.1002/ejp.1557
EP  - 1137
PY  - 2020///
SN  - 1090-3801
SP  - 1130
TI  - Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin-induced dynamic mechanical allodynia and mechanical pain sensitivity in humans.
T2  - European Journal of Pain
UR  - http://dx.doi.org/10.1002/ejp.1557
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32170802
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1557
UR  - http://hdl.handle.net/10044/1/77753
VL  - 24
ER  -
Download