Imperial College London
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DrPaulStrutton

Faculty of Medicine, Department of Surgery & Cancer

Reader in Human Neurophysiology
 
 
 
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Contact

 

+44 (0)20 7594 3239p.strutton

 
 
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Location

 

205Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bonsu:2021:10.1007/s00221-021-06123-7,
author = {Bonsu, AN and Nousi, S and Lobo, R and Strutton, PH and Arshad, Q and Bronstein, AM},
doi = {10.1007/s00221-021-06123-7},
journal = {Experimental Brain Research},
pages = {2141--2149},
title = {Vestibulo-perceptual influences upon the vestibulo-spinal reflex},
url = {http://dx.doi.org/10.1007/s00221-021-06123-7},
volume = {239},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The vestibular system facilitates gaze and postural stability via the vestibulo-ocular (VOR) and vestibulo-spinal reflexes, respectively. Cortical and perceptual mechanisms can modulate long-duration VOR responses, but little is known about whether high-order neural phenomena can modulate short-latency vestibulo-spinal responses. Here, we investigate this by assessing click-evoked cervical vestibular myogenic-evoked potentials (VEMPS) during visual roll motion that elicited an illusionary sensation of self-motion (i.e. vection). We observed that during vection, the amplitude of the VEMPs was enhanced when compared to baseline measures. This modulation in VEMP amplitude was positively correlated with the subjective reports of vection strength. That is, those subjects reporting greater subjective vection scores exhibited a greater increase in VEMP amplitude. Control experiments showed that simple arousal (cold-induced discomfort) also increased VEMP amplitude but that, unlike vection, it did not modulate VEMP amplitude linearly. In agreement, small-field visual roll motion that did not induce vection failed to increase VEMP amplitude. Taken together, our results demonstrate that vection can modify the response of vestibulo-collic reflexes. Even short-latency brainstem vestibulo-spinal reflexes are influenced by high-order mechanisms, illustrating the functional importance of perceptual mechanisms in human postural control. As VEMPs are inhibitory responses, we argue that the findings may represent a mechanism whereby high-order CNS mechanisms reduce activity levels in vestibulo-collic reflexes, necessary for instance when voluntary head movements need to be performed.
AU  - Bonsu,AN
AU  - Nousi,S
AU  - Lobo,R
AU  - Strutton,PH
AU  - Arshad,Q
AU  - Bronstein,AM
DO  - 10.1007/s00221-021-06123-7
EP  - 2149
PY  - 2021///
SN  - 0014-4819
SP  - 2141
TI  - Vestibulo-perceptual influences upon the vestibulo-spinal reflex
T2  - Experimental Brain Research
UR  - http://dx.doi.org/10.1007/s00221-021-06123-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000648495700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs00221-021-06123-7
UR  - http://hdl.handle.net/10044/1/94055
VL  - 239
ER  -
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