Imperial College London
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DrPanteleimonTakis

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Associate
 
 
 
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Contact

 

p.takis Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2021:10.1016/j.isci.2021.103353,
author = {de, Silva TI and Liu, G and Lindsey, BB and Dong, D and Moore, SC and Hsu, NS and Shah, D and Wellington, D and Mentzer, AJ and Angyal, A and Brown, R and Parker, MD and Ying, Z and Yao, X and Turtle, L and Dunachie, S and COVID-19, Genomics UK COG-UK Consortium and Maini, MK and Ogg, G and Knight, JC and ISARIC4C, Investigators and Peng, Y and Rowland-Jones, SL and Dong, T},
doi = {10.1016/j.isci.2021.103353},
journal = {iScience},
pages = {103353--103353},
title = {The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.},
url = {http://dx.doi.org/10.1016/j.isci.2021.103353},
volume = {24},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.
AU  - de,Silva TI
AU  - Liu,G
AU  - Lindsey,BB
AU  - Dong,D
AU  - Moore,SC
AU  - Hsu,NS
AU  - Shah,D
AU  - Wellington,D
AU  - Mentzer,AJ
AU  - Angyal,A
AU  - Brown,R
AU  - Parker,MD
AU  - Ying,Z
AU  - Yao,X
AU  - Turtle,L
AU  - Dunachie,S
AU  - COVID-19,Genomics UK COG-UK Consortium
AU  - Maini,MK
AU  - Ogg,G
AU  - Knight,JC
AU  - ISARIC4C,Investigators
AU  - Peng,Y
AU  - Rowland-Jones,SL
AU  - Dong,T
DO  - 10.1016/j.isci.2021.103353
EP  - 103353
PY  - 2021///
SN  - 2589-0042
SP  - 103353
TI  - The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
T2  - iScience
UR  - http://dx.doi.org/10.1016/j.isci.2021.103353
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34729465
UR  - https://www.cell.com/iscience/fulltext/S2589-0042(21)01322-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221013225%3Fshowall%3Dtrue
UR  - http://hdl.handle.net/10044/1/93203
VL  - 24
ER  -
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