Imperial College London
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DrPanteleimonTakis

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Associate
 
 
 
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Contact

 

p.takis Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vink:2022:ofid/ofac531,
author = {Vink, E and Davis, C and MacLean, A and Pascall, D and McDonald, SE and Gunson, R and Hardwick, HE and Oosthuyzen, W and Openshaw, PJM and Baillie, JK and Semple, MG and Ho, A},
doi = {ofid/ofac531},
journal = {Open Forum Infectious Diseases},
pages = {1--10},
title = {Viral coinfections in hospitalized Coronavirus disease 2019 patients recruited to the international severe acute respiratory and emerging infections consortium WHO clinical characterisation protocol UK study},
url = {http://dx.doi.org/10.1093/ofid/ofac531},
volume = {9},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundWe conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity.MethodsMultiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge.ResultsA coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity.ConclusionsViral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward.
AU  - Vink,E
AU  - Davis,C
AU  - MacLean,A
AU  - Pascall,D
AU  - McDonald,SE
AU  - Gunson,R
AU  - Hardwick,HE
AU  - Oosthuyzen,W
AU  - Openshaw,PJM
AU  - Baillie,JK
AU  - Semple,MG
AU  - Ho,A
DO  - ofid/ofac531
EP  - 10
PY  - 2022///
SN  - 2328-8957
SP  - 1
TI  - Viral coinfections in hospitalized Coronavirus disease 2019 patients recruited to the international severe acute respiratory and emerging infections consortium WHO clinical characterisation protocol UK study
T2  - Open Forum Infectious Diseases
UR  - http://dx.doi.org/10.1093/ofid/ofac531
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000880864400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://academic.oup.com/ofid/article/9/11/ofac531/6754723
UR  - http://hdl.handle.net/10044/1/101581
VL  - 9
ER  -
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