Publications
419 results found
Evans J, Tait D, Swift I, et al., 2011, Timing of Surgery Following Preoperative Therapy in Rectal Cancer: The Need for a Prospective Randomized Trial?, DISEASES OF THE COLON & RECTUM, Vol: 54, Pages: 1251-1259, ISSN: 0012-3706
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- Citations: 51
Reid CB, Fitzgerald A, Reese G, et al., 2011, Terahertz pulsed imaging of freshly excised human colonic tissues, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 56, Pages: 4333-4353, ISSN: 0031-9155
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- Citations: 123
Tekkis P, 2011, Commentary on Nielsen <i>et al.</i>, COLORECTAL DISEASE, Vol: 13, Pages: 742-743, ISSN: 1462-8910
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- Citations: 1
Mills S, von Roon AC, Tekkis PP, et al., 2011, Crohn Disease, AMERICAN FAMILY PHYSICIAN, Vol: 83, Pages: 1479-1481, ISSN: 0002-838X
Mills S, von Roon AC, Tekkis PP, et al., 2011, Crohn disease., Am Fam Physician, Vol: 83, Pages: 1479-1481
Taylor FGM, Quirke P, Heald RJ, et al., 2011, One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer, BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 872-879, ISSN: 0007-1323
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- Citations: 114
Cornish JA, Tekkis PP, Tan E, et al., 2011, The national bowel cancer audit project: The impact of organisational structure on outcome in operative bowel cancer within the United Kingdom, SURGICAL ONCOLOGY-OXFORD, Vol: 20, Pages: E72-E77, ISSN: 0960-7404
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- Citations: 20
Mills SC, von Roon AC, Tekkis PP, et al., 2011, Crohn's disease., BMJ Clin Evid, Vol: 2011
INTRODUCTION: Crohn's disease is a chronic condition of the gastrointestinal tract. It is characterised by transmural, granulomatous inflammation that occurs in a discontinuous pattern, with a tendency to form fistulae. The cause is unknown but may depend on interactions between genetic predisposition, environmental triggers, and mucosal immunity. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of medical treatments to induce remission in adults with Crohn's disease? What are the effects of surgical interventions to induce and maintain remission in adults with small-bowel Crohn's disease? What are the effects of surgical interventions to induce remission in adults with colonic Crohn's disease? What are the effects of medical interventions to maintain remission in adults with Crohn's disease; and to maintain remission following surgery? What are the effects of lifestyle interventions to maintain remission in adults with Crohn's disease? We searched: Medline, Embase, The Cochrane Library, and other important databases up to December 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 93 systematic reviews, RCTs, or observational studies that met our inclusion criteria. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: aminosalicylates, antibiotics, azathioprine/mercaptopurine, ciclosporin, corticosteroids (oral), enteral nutrition, fish oil, infliximab, methotrexate, probiotics, resection, segmental colectomy, smoking cessation, and strictureplasty.
Taylor FGM, Quirke P, Heald RJ, et al., 2011, Preoperative High-resolution Magnetic Resonance Imaging Can Identify Good Prognosis Stage I, II, and III Rectal Cancer Best Managed by Surgery Alone <i>A Prospective, Multicenter, European Study</i>, ANNALS OF SURGERY, Vol: 253, Pages: 711-719, ISSN: 0003-4932
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- Citations: 423
McLaughlin SD, Clark SK, Tekkis PP, et al., 2011, An open study of maintenance antibiotic therapy for chronic antibiotic-dependent pouchitis: efficacy, complications and outcome, COLORECTAL DISEASE, Vol: 13, Pages: 438-444, ISSN: 1462-8910
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- Citations: 14
Skouras C, Purkayastha S, Jiao L, et al., 2011, Laparoscopic Management of Spigelian Hernias, SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, Vol: 21, Pages: 76-81, ISSN: 1530-4515
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- Citations: 17
Cornish JA, Tilney HS, Tan E, et al., 2011, The National Bowel Cancer Audit Project: what do trusts think of the National Bowel Cancer Audit and how can it be improved?, TECHNIQUES IN COLOPROCTOLOGY, Vol: 15, Pages: 53-59, ISSN: 1123-6337
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- Citations: 4
Tan E, Ngo N-T, Darzi A, et al., 2011, Meta-analysis: sacral nerve stimulation versus conservative therapy in the treatment of faecal incontinence, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 26, Pages: 275-294, ISSN: 0179-1958
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- Citations: 62
Mazaris EM, Crane JS, Warrens AN, et al., 2011, Attitudes toward live donor kidney transplantation and its commercialization, CLINICAL TRANSPLANTATION, Vol: 25, Pages: E312-E319, ISSN: 0902-0063
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- Citations: 11
Tekkis PP, Georgiou PA, Constantinides VA, et al., 2011, Diagnostic accuracy and value of magnetic resonance imaging (MRI) in planning exenterative pelvic surgery for advanced colorectal pelvic cancer, JOURNAL OF CLINICAL ONCOLOGY, Vol: 29, ISSN: 0732-183X
Hunter CJ, Scurr E, Jeyadevan N, et al., 2011, Optimising magnetic resonance imaging for preoperative staging and surgical planning in colon cancer at 1.5 tesla and 3.0 tesla, JOURNAL OF CLINICAL ONCOLOGY, Vol: 29, ISSN: 0732-183X
Georgiou PA, Tekkis PP, Patel U, et al., 2011, The added value of diffusion-weighted magnetic resonance imaging (DW-MRI) in the local staging of advanced colorectal pelvic cancer, JOURNAL OF CLINICAL ONCOLOGY, Vol: 29, ISSN: 0732-183X
von Roon AC, Will OCC, Man RF, et al., 2011, Mucosectomy With Handsewn Anastomosis Reduces the Risk of Adenoma Formation in the Anorectal Segment After Restorative Proctocolectomy for Familial Adenomatous Polyposis, ANNALS OF SURGERY, Vol: 253, Pages: 314-317, ISSN: 0003-4932
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- Citations: 34
Lovegrove RE, Tilney HS, Remzi FH, et al., 2011, To Divert or Not to Divert <i>A Retrospective Analysis of Variables That Influence Ileostomy Omission in Ileal Pouch Surgery</i>, ARCHIVES OF SURGERY, Vol: 146, Pages: 82-88, ISSN: 0004-0010
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- Citations: 30
Burns EM, Bottle A, Aylin P, et al., 2011, Volume analysis of outcome following restorative proctocolectomy, The British journal of surgery, Vol: 98, Pages: 408-417, ISSN: 1365-2168
BACKGROUND: This observational study aimed to determine national provision and outcome following pouch surgery (restorative proctocolectomy, RPC) and to examine the effect of institutional and surgeon caseload on outcome. METHODS: All patients undergoing primary RPC between April 1996 and March 2008 in England were identified from the administrative database Hospital Episode Statistics. Institutions and surgeons were categorized according to the total RPC caseload performed over the study interval. RESULTS: Some 5771 primary elective pouch procedures were undertaken at 154 National Health Service hospital trusts. Median follow-up was 65 (interquartile range (i.q.r.) 28-106) months. The 30-day in-hospital mortality rate was 0.5 per cent and the 1-year overall mortality rate 1.5 per cent. Some 30.5 per cent of trusts performed fewer than two procedures per year, and 91.4 per cent of surgical teams (456 of 499) carried out 20 or fewer RPCs over 8 years. Median surgeon volume was 4 (i.q.r. 1-9) cases. Failure occurred in 6.4 per cent of cases. Low-volume surgeons operated on more patients at the extremes of age (P < 0.001) and a lower proportion with ulcerative colitis (P < 0.001). Older age, increasing co-morbidity, increasing social deprivation, and both lower provider and surgeon caseload were independent predictors of longer length of stay. Older patient age and low institutional volume status were independent predictors of failure. CONCLUSION: Many English institutions and surgeons carry out extremely low volumes of RPC surgery. Case selection differed significantly between high- and low-volume surgeons. Institutional volume and older age were positively associated with increased pouch failure.
Mills SC, von Roon AC, Tekkis PP, et al., 2010, Crohn's disease., BMJ Clin Evid, Vol: 2010
INTRODUCTION: Crohn's disease is a chronic condition of the gastrointestinal tract. It is characterised by transmural, granulomatous inflammation that occurs in a discontinuous pattern, with a tendency to form fistulae. The cause is unknown but may depend on interactions between genetic predisposition, environmental triggers, and mucosal immunity. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of medical treatments to induce remission in adults with Crohn's disease? What are the effects of surgical interventions to induce and maintain remission in adults with small-bowel Crohn's disease? What are the effects of surgical interventions to induce remission in adults with colonic Crohn's disease? What are the effects of medical interventions to maintain remission in adults with Crohn's disease; and to maintain remission following surgery? What are the effects of lifestyle interventions to maintain remission in adults with Crohn's disease? We searched: Medline, Embase, The Cochrane Library, and other important databases up to December 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 93 systematic reviews, RCTs, or observational studies that met our inclusion criteria. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: aminosalicylates, antibiotics, azathioprine/mercaptopurine, ciclosporin, corticosteroids (oral), enteral nutrition, fish oil, infliximab, methotrexate, probiotics, resection, segmental colectomy, smoking cessation, and strictureplasty.
Sinha A, Tekkis PP, Rashid S, et al., 2010, Risk factors for secondary proctectomy in patients with familial adenomatous polyposis, BRITISH JOURNAL OF SURGERY, Vol: 97, Pages: 1710-1715, ISSN: 0007-1323
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- Citations: 35
Panayi DC, Khullar V, Fernando R, et al., 2010, Transvaginal ultrasound measurement of bladder wall thickness: a more reliable approach than transperineal and transabdominal approaches, BJU INTERNATIONAL, Vol: 106, Pages: 1519-1522, ISSN: 1464-4096
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- Citations: 19
McLaughlin SD, Clark SK, Tekkis PP, et al., 2010, The bacterial pathogenesis and treatment of pouchitis., Therap Adv Gastroenterol, Vol: 3, Pages: 335-348
Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the operation of choice for patients with ulcerative colitis. Pouchitis is the most common cause of pouch dysfunction. Although the pathogenesis of this disease is not well understood, bacteria have been implicated in the disease process. Numerous bacterial studies have been reported over the last 25 years with few unifying findings. In addition, many different treatments for pouchitis have been reported with varying results. Antibiotic treatment remains the most studied and is the mainstay of treatment. In this article we review the aetiology of pouchitis and the evidenced-based treatment options.
Hariharan D, Constantinides VA, Froeling FEM, et al., 2010, The role of laparoscopy and laparoscopic ultrasound in the preoperative staging of pancreatico-biliary cancers - A meta-analysis, EJSO, Vol: 36, Pages: 941-948, ISSN: 0748-7983
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- Citations: 38
Ngo N-T, Tan E, Tekkis P, et al., 2010, Differential expression of p53 and p504s in hyperplastic polyp, sessile serrated adenoma and traditional serrated adenoma, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 25, Pages: 1193-1200, ISSN: 0179-1958
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- Citations: 6
Smith JJ, Nicholls RJ, 2010, The Development of a Social Morbidity Score in Patients with Chronic Ulcerative Colitis as a Guide to Treatment, QUALITY OF LIFE RESEARCH, Vol: 19, Pages: 116-116, ISSN: 0962-9343
Panayi DC, Digesu GA, Tekkis P, et al., 2010, Ultrasound measurement of vaginal wall thickness: a novel and reliable technique, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 21, Pages: 1265-1270, ISSN: 0937-3462
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- Citations: 36
Digesu GA, Panayi D, Kundi N, et al., 2010, Validity of the Rome III Criteria in assessing constipation in women, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 21, Pages: 1185-1193, ISSN: 0937-3462
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- Citations: 16
McLaughlin SD, Clark SK, Roberts CH, et al., 2010, Extended spectrum beta-lactamase-producing bacteria and <i>Clostridium difficile</i> in patients with pouchitis, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 32, Pages: 664-669, ISSN: 0269-2813
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- Citations: 12
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