Publications
419 results found
Rasheed S, Harris AL, Tekkis PP, et al., 2009, Hypoxia-inducible factor-1α and-2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis, BRITISH JOURNAL OF CANCER, Vol: 100, Pages: 1666-1673, ISSN: 0007-0920
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- Citations: 65
McLaughlin SD, Clark SK, Shafi S, et al., 2009, Fecal Coliform Testing to Identify Effective Antibiotic Therapies for Patients With Antibiotic-Resistant Pouchitis, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol: 7, Pages: 545-548, ISSN: 1542-3565
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- Citations: 38
Moreira ADL, Stocchi L, Tan E, et al., 2009, Outcomes of Crohn's Disease Presenting with Abdominopelvic Abscess, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 906-912, ISSN: 0012-3706
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- Citations: 38
McLaughlin SD, Clark SK, Bell AJ, et al., 2009, Incidence and Short-Term Implications of Prepouch Ileitis Following Restorative Proctocolectomy with Ileal Pouch-Anal Anastomosis for Ulcerative Colitis, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 879-883, ISSN: 0012-3706
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- Citations: 22
Postgate A, Tekkis P, Patterson N, et al., 2009, Are bowel purgatives and prokinetics useful for small-bowel capsule endoscopy? A prospective randomized controlled study, GASTROINTESTINAL ENDOSCOPY, Vol: 69, Pages: 1120-1128, ISSN: 0016-5107
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- Citations: 61
McLaughlin SD, Clark SK, Perry-Woodford ZL, et al., 2009, QUALITY OF LIFE AND FUNCTIONAL OUTCOME IN PATIENTS USING A MEDINA CATHETER FOLLOWING RESTORATIVE PROCTOCOLECTOMY, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A93-A93, ISSN: 0017-5749
McLaughlin SD, Clark SK, Petrovska L, et al., 2009, A NOVEL TEST TO PREDICT EFFECTIVE TREATMENT REGIMENS FOR PATIENTS WITH ANTIBIOTIC RESISTANT POUCHITIS, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A12-A12, ISSN: 0017-5749
Antcliffe D, Nanidis TG, Darzi AW, et al., 2009, A meta-analysis of mini-open versus standard open and laparoscopic living donor nephrectomy, TRANSPLANT INTERNATIONAL, Vol: 22, Pages: 463-474, ISSN: 0934-0874
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- Citations: 32
McLaughlin SD, Clark SK, Shafi S, et al., 2009, MAINTENANCE ANTIBIOTIC THERAPY FOR CHRONIC POUCHITIS, COMPLICATIONS AND CLINICAL OUTCOME, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A93-A93, ISSN: 0017-5749
Tan E, Gouvas N, Nicholls RJ, et al., 2009, Diagnostic precision of carcinoembryonic antigen in the detection of recurrence of colorectal cancer, SURGICAL ONCOLOGY-OXFORD, Vol: 18, Pages: 15-24, ISSN: 0960-7404
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- Citations: 163
Reese GE, von Roon AC, Tekkis PP, 2009, Haemorrhoids., BMJ Clin Evid, Vol: 2009
INTRODUCTION: Haemorrhoids are cushions of submucosal vascular tissue located in the anal canal starting just distal to the dentate line. Incidence is difficult to ascertain as many people with the condition will never consult with a medical practitioner, although one study found 10 million people in the USA complaining of the disease. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for haemorrhoidal disease? We searched: Medline, Embase, The Cochrane Library, and other important databases up to May 2008 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 44 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: closed haemorrhoidectomy, haemorrhoidal artery ligation, infrared coagulation/photocoagulation, injection sclerotherapy, open excisional (Milligan-Morgan/diathermy) haemorrhoidectomy, radiofrequency ablation, rubber band ligation, and stapled haemorrhoidectomy.
Mclaughlin SD, Clark SK, Bell AJ, et al., 2009, An open study of antibiotics for the treatment of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 29, Pages: 69-74, ISSN: 0269-2813
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- Citations: 14
Tekkis PP, Cornish JA, Remzi FH, et al., 2009, Measuring Sexual and Urinary Outcomes in Women after Rectal Cancer Excision, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 46-54, ISSN: 0012-3706
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- Citations: 95
Iqbal N, Lovegrove RE, Tilney HS, et al., 2009, A comparison of pancreaticoduodenectomy with extended pancreaticoduodenectomy: A meta-analysis of 1909 patients, EJSO, Vol: 35, Pages: 79-86, ISSN: 0748-7983
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- Citations: 54
Faiz O, Warusavitarne J, Bottle A, et al., 2009, Laparoscopically assisted vs. open elective colonic and rectal resection: a comparison of outcomes in English National Health Service Trusts between 1996 and 2006, Diseases of the colon and rectum, Vol: 52, Pages: 1695-1704, ISSN: 1530-0358
PURPOSE: This study was designed to compare outcomes after elective laparoscopic and conventional colorectal surgery over a ten-year period using data from the English National Health Service Hospital Episode Statistics database. METHODS: All elective colonic and rectal resections carried out in English Trusts between 1996 and 2006 were included. Univariate and multivariate analyses were used to compare 30 and 365-day mortality rates, 28-day readmission rates, and length of stay between laparoscopic and open surgery. RESULTS: Between the study dates 3,709 of 192,620 (1.9%) elective colonic and rectal resections were classified as laparoscopically assisted procedures. The 30-day and 365-day mortality rates were lower after laparoscopic resection than after open surgery (P < 0.05). After correction for age, gender, diagnosis, operation type, comorbidity, and social deprivation, laparoscopic surgery was a strong determinant of reduced 30-day (odds ratio, 0.57; 95% confidence interval, 0.44-0.74; P < 0.001) and one-year (odds ratio, 0.53; 95% confidence interval, 0.42-0.67; P < 0.001) mortality. Similarly, multivariate analysis confirmed that laparoscopic surgery was independently associated with reduced hospital stay (P < 0.001). Patients who received rectal procedures for malignancy, however, were more likely to be readmitted if laparoscopy rather than by a traditional method was used (11.9% vs. 9.1%, P = 0.003). CONCLUSION: In the present study, patients selected for laparoscopic colorectal surgery were associated with reduced postoperative mortality when compared with those undergoing the conventional technique. This finding merits further investigation.
Jeyarajah S, Faiz O, Bottle A, et al., 2009, Diverticular disease hospital admissions are increasing, with poor outcomes in the elderly and emergency admissions, Alimentary pharmacology & therapeutics, Vol: 30, Pages: 1171-1182, ISSN: 1365-2036
BACKGROUND: Diverticular disease has a changing disease pattern with limited epidemiological data. AIM: To describe diverticular disease admission rates and associated outcomes through national population study. METHODS: Data were obtained from the English 'Hospital Episode Statistics' database between 1996 and 2006. Primary outcomes examined were 30-day overall and 1-year mortality, 28-day readmission rates and extended length of stay (LOS) beyond the 75th percentile (median inpatient LOS = 6 days). Multiple logistic regression analysis was used to determine independent predictors of these outcomes. RESULTS: Between the study dates 560 281 admissions with a primary diagnosis of diverticular disease were recorded in England. The national admission rate increased from 0.56 to 1.20 per 1000 population/year. 232 047 (41.4%) were inpatient admissions and, of these, 55 519 (23.9%) were elective and 176 528 (76.1%) emergency. Surgery was undertaken in 37 767 (16.3%). The 30-day mortality was 5.1% (n = 6735) and 1-year mortality was 14.5% (n = 11 567). The 28-day readmission rate was 9.6% (n = 21 160). Increasing age, comorbidity and emergency admission were independent predictors of all primary outcomes. CONCLUSIONS: Diverticular disease admissions increased over the course of the study. Patients of increasing age, admitted as emergency and significant comorbidity should be identified, allowing management modification to optimize outcomes.
Mazaris EM, Warrens AW, Tekkis P, et al., 2009, Initial Approach of a Potential Live Donor, Motives for Live Donation and Factors Promoting Live Donor Kidney Transplantation., 9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 607-607, ISSN: 1600-6135
Rasheed S, Harris AL, Tekkis PP, et al., 2009, Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer, PATHOLOGY RESEARCH AND PRACTICE, Vol: 205, Pages: 1-9, ISSN: 0344-0338
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- Citations: 26
Panayi D, Khullar V, Fernando R, et al., 2009, IS ULTRASOUND BLADDER WALL THICKNESS A BETTER OBJECTIVE MEASURE THAN URODYNAMICS FOR OVERACTIVE BLADDER SYMPTOMS?, 39th Annual Meeting of the International-Continence-Society, Publisher: WILEY-LISS, Pages: 780-781, ISSN: 0733-2467
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- Citations: 1
Mazaris EM, Warrens AW, Tekkis P, et al., 2009, Attitudes of Healthcare Professionals and Patients towards Live Donor Kidney Transplantation., 9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 606-606, ISSN: 1600-6135
Jeyarajah S, Chow A, Lloyd J, et al., 2009, Follow-up in patients with disseminated peritoneal leiomyomatosis: a report of an unusual, high-risk case., BMJ Case Rep, Vol: 2009
Leiomyomatosis peritonei disseminata is a condition seen uncommonly in states of oestrogen hypersecretion in women of childbearing age. There are no clear guidelines for the primary management and follow-up of these patients. Here, a rare case in a postmenopausal woman with a normal hormonal state who may be considered higher risk is presented, with a review suggesting a management pathway in these patients.
Lanitis S, Starren E, Read J, et al., 2008, Surgical management of Gynaecomastia: Outcomes from our experience, BREAST, Vol: 17, Pages: 596-603, ISSN: 0960-9776
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- Citations: 26
Tilney HS, Purkayastha S, Darzi AW, et al., 2008, APER Rate Has Multiple Limitations as an Indicator of Quality in Rectal Cancer Surgery Reply, ANNALS OF SURGERY, Vol: 248, Pages: 1105-1106, ISSN: 0003-4932
Reese GE, Nanidis T, Borysiewicz C, et al., 2008, The effect of smoking after surgery for Crohn's disease: a meta-analysis of observational studies, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 23, Pages: 1213-1221, ISSN: 0179-1958
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- Citations: 208
Iqbal N, Lovegrove RE, Tilney HS, et al., 2008, A comparison of pancreaticoduodenectomy with pylorus preserving pancreaticoduodenectomy: A meta-analysis of 2822 patients, EJSO, Vol: 34, Pages: 1237-1245, ISSN: 0748-7983
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- Citations: 38
Lovegrove RE, Symeonides P, Tekkis PP, et al., 2008, A selective approach to restorative proctocolectomy without ileostomy: a single centre experience, COLORECTAL DISEASE, Vol: 10, Pages: 916-924, ISSN: 1462-8910
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- Citations: 17
East JE, Tan EK, Bergman JJ, et al., 2008, Meta-analysis: narrow band imaging for lesion characterization in the colon, oesophagus, duodenal ampulla and lung, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 28, Pages: 854-867, ISSN: 0269-2813
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- Citations: 47
Purkayastha S, Tekkis PP, Athanasiou T, et al., 2008, One falsehood easily leads to another - Reply, DISEASES OF THE COLON & RECTUM, Vol: 51, Pages: 1588-1588, ISSN: 0012-3706
Ngo N, Tan E, Tekkis P, et al., 2008, Differential expression of p53 and p504s in sessile serrated polyps and traditional serrated adenomas as markers of malignant potential, 27th International Congress of the International-Academy-of-Pathology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 152-152, ISSN: 0309-0167
East JE, Suzuki N, Bassett P, et al., 2008, Narrow band imaging with magnification for the characterization of small and diminutive colonic polyps: pit pattern and vascular pattern intensity, ENDOSCOPY, Vol: 40, Pages: 811-817, ISSN: 0013-726X
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- Citations: 110
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