Publications
419 results found
Dighe S, Purkayastha S, Swift I, et al., 2010, Diagnostic precision of CT in local staging of colon cancers: a meta-analysis, CLINICAL RADIOLOGY, Vol: 65, Pages: 708-719, ISSN: 0009-9260
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- Citations: 119
Welsh F, Tekkis PP, John TG, et al., 2010, Open liver resection for colorectal metastases: better short- and long-term outcomes in patients potentially suitable for laparoscopic liver resection, HPB, Vol: 12, Pages: 435-435, ISSN: 1365-182X
Thompson MR, Tekkis PP, Stamatakis J, et al., 2010, The National Bowel Cancer Audit: the risks and benefits of moving to open reporting of clinical outcomes, COLORECTAL DISEASE, Vol: 12, Pages: 783-791, ISSN: 1462-8910
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- Citations: 8
McLaughlin SD, Walker AW, Churcher C, et al., 2010, The Bacteriology of Pouchitis <i>A Molecular Phylogenetic Analysis Using 16S rRNA Gene Cloning and Sequencing</i>, ANNALS OF SURGERY, Vol: 252, Pages: 90-98, ISSN: 0003-4932
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- Citations: 86
Sinha A, Tekkis PP, Neale KF, et al., 2010, Risk factors predicting intra-abdominal desmoids in familial adenomatous polyposis: a single centre experience, TECHNIQUES IN COLOPROCTOLOGY, Vol: 14, Pages: 141-146, ISSN: 1123-6337
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- Citations: 17
Simillis C, Symeonides P, Shorthouse AJ, et al., 2010, A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon), SURGERY, Vol: 147, Pages: 818-829, ISSN: 0039-6060
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- Citations: 205
Lovegrove RE, Fazio VW, Remzi FH, et al., 2010, Development of a pouch functional score following restorative proctocolectomy, BRITISH JOURNAL OF SURGERY, Vol: 97, Pages: 945-951, ISSN: 0007-1323
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- Citations: 24
Tekkis PP, Lovegrove RE, Tilney HS, et al., 2010, Long-term failure and function after restorative proctocolectomy - a multi-centre study of patients from the UK national ileal pouch registry, COLORECTAL DISEASE, Vol: 12, Pages: 433-441, ISSN: 1462-8910
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- Citations: 90
Panayi DC, Khullar V, Fernando R, et al., 2010, Mean bladder wall thickness is an accurate objective measure of overactive bladder symptoms in women, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 117, Pages: 628-628, ISSN: 1470-0328
Welsh FKS, Tekkis PP, John TG, et al., 2010, Open liver resection for colorectal metastases: better short- and long-term outcomes in patients potentially suitable for laparoscopic liver resection, HPB, Vol: 12, Pages: 188-194, ISSN: 1365-182X
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- Citations: 29
Lanitis S, Tekkis PP, Sgourakis G, et al., 2010, Comparison of Skin-Sparing Mastectomy Versus Non-Skin-Sparing Mastectomy for Breast Cancer <i>A Meta</i>-<i>Analysis of Observational Studies</i>, ANNALS OF SURGERY, Vol: 251, Pages: 632-639, ISSN: 0003-4932
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- Citations: 139
Haycock AV, Patel JH, Tekkis PP, et al., 2010, Evaluating changes in gastrointestinal endoscopy training over 5 years: closing the audit loop, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 22, Pages: 368-373, ISSN: 0954-691X
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- Citations: 10
Georgiou P, Tan E, Gouvas N, et al., 2010, Lateral pelvic lymph-node dissection: still an option for cure Reply, LANCET ONCOLOGY, Vol: 11, Pages: 114-115, ISSN: 1470-2045
Simillis C, Jacovides M, Reese GE, et al., 2010, Meta-analysis of the Role of Granulomas in the Recurrence of Crohn Disease, DISEASES OF THE COLON & RECTUM, Vol: 53, Pages: 177-185, ISSN: 0012-3706
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- Citations: 56
McLaughlin SD, Perry-Woodford ZL, Clark SK, et al., 2010, Osteoporosis in Patients Over 50 Years of Age Following Restorative Proctocolectomy for Ulcerative Colitis: Is DXA Screening Warranted?, INFLAMMATORY BOWEL DISEASES, Vol: 16, Pages: 250-255, ISSN: 1078-0998
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- Citations: 8
Faiz O, Warusavitarne J, Bottle A, et al., 2010, Nonelective excisional colorectal surgery in English National Health Service Trusts: a study of outcomes from Hospital Episode Statistics Data between 1996 and 2007, Journal of the American College of Surgeons, Vol: 210, Pages: 390-401, ISSN: 1879-1190
BACKGROUND: Nonelective colorectal surgery is associated with substantial patient morbidity and mortality. This study sought to describe the practice of emergency colorectal surgery in the United Kingdom during an 11-year period using the Hospital Episode Statistics (HES) database. STUDY DESIGN: All nonelective admissions in patients undergoing 1 of 8 colorectal resectional procedures between 1996 and 2007 were included. Time trends, univariate, and multivariate mortality and length of stay outcomes were analyzed. RESULTS: A total of 102,236 major urgent/emergency procedures were performed in English National Health Service Trusts between April 1996 and March 2007. Thirty-day in-hospital postoperative mortality rates in patients with colorectal cancer and diverticular disease were 13.3% and 15.4%, respectively. The corresponding 1-year postoperative mortality was 34.7% and 22.6%. On multivariate analysis, benign diagnosis, advanced age, high comorbidity score, social deprivation, and specific procedure types were independent predictors of early and 1-year postoperative mortality (p < 0.001). Independent risk factors for extended hospital stay were advanced age, social deprivation, distal (compared with proximal) bowel resection, and a diagnosis of ulcerative colitis (p < 0.001). CONCLUSIONS: HES data suggest that in everyday practice, postoperative mortality among patients undergoing nonelective admission followed by colorectal resection is high. Additional investigation is required to assess the reliability of HES data for monitoring institutional variation in this context.
Panayi DC, Tekkis P, Fernando R, et al., 2010, Ultrasound Measurement of Bladder Wall Thickness Is Associated With the Overactive Bladder Syndrome, NEUROUROLOGY AND URODYNAMICS, Vol: 29, Pages: 1295-1298, ISSN: 0733-2467
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- Citations: 22
Yakoub D, Athanasiou T, Tekkis P, et al., 2009, Laparoscopic assisted distal gastrectomy for early gastric cancer: Is it an alternative to the open approach?, SURGICAL ONCOLOGY-OXFORD, Vol: 18, Pages: 322-333, ISSN: 0960-7404
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- Citations: 90
Panayi DC, Khullar V, Digesu GA, et al., 2009, Is ultrasound estimation of bladder weight a useful tool in the assessment of patients with lower urinary tract symptoms?, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 20, Pages: 1445-1449, ISSN: 0937-3462
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- Citations: 12
Georgiou P, Tan E, Gouvas N, et al., 2009, Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysis, LANCET ONCOLOGY, Vol: 10, Pages: 1053-1062, ISSN: 1470-2045
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- Citations: 217
Haycock AV, Youd P, Bassett P, et al., 2009, Simulator training improves practical skills in therapeutic GI endoscopy: results from a randomized, blinded, controlled study, GASTROINTESTINAL ENDOSCOPY, Vol: 70, Pages: 835-845, ISSN: 0016-5107
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- Citations: 57
O'Rourke TR, Welsh FKS, Tekkis PP, et al., 2009, Accuracy of liver-specific magnetic resonance imaging as a predictor of chemotherapy-associated hepatic cellular injury prior to liver resection, EJSO, Vol: 35, Pages: 1085-1091, ISSN: 0748-7983
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- Citations: 27
Tilney HS, Rasheed S, Northover JM, et al., 2009, The Influence of Circumferential Resection Margins on Long-Term Outcomes Following Rectal Cancer Surgery, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 1723-1729, ISSN: 0012-3706
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- Citations: 63
Gouvas N, Tan E, Windsor A, et al., 2009, Fast-track vs standard care in colorectal surgery: a meta-analysis update, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 24, Pages: 1119-1131, ISSN: 0179-1958
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- Citations: 205
Ergina PL, Cook JA, Blazeby JM, et al., 2009, Challenges in evaluating surgical innovation., Lancet, Vol: 374, Pages: 1097-1104
Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide. In this report, the second of three on surgical innovation and evaluation, we discuss obstacles related to the study design of randomised controlled trials and non-randomised studies assessing surgical interventions. We also describe the issues related to the nature of surgical procedures-for example, their complexity, surgeon-related factors, and the range of outcomes. Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential.
McCulloch P, Altman DG, Campbell WB, et al., 2009, No surgical innovation without evaluation: the IDEAL recommendations., Lancet, Vol: 374, Pages: 1105-1112
Surgery and other invasive therapies are complex interventions, the assessment of which is challenged by factors that depend on operator, team, and setting, such as learning curves, quality variations, and perception of equipoise. We propose recommendations for the assessment of surgery based on a five-stage description of the surgical development process. We also encourage the widespread use of prospective databases and registries. Reports of new techniques should be registered as a professional duty, anonymously if necessary when outcomes are adverse. Case series studies should be replaced by prospective development studies for early technical modifications and by prospective research databases for later pre-trial evaluation. Protocols for these studies should be registered publicly. Statistical process control techniques can be useful in both early and late assessment. Randomised trials should be used whenever possible to investigate efficacy, but adequate pre-trial data are essential to allow power calculations, clarify the definition and indications of the intervention, and develop quality measures. Difficulties in doing randomised clinical trials should be addressed by measures to evaluate learning curves and alleviate equipoise problems. Alternative prospective designs, such as interrupted time series studies, should be used when randomised trials are not feasible. Established procedures should be monitored with prospective databases to analyse outcome variations and to identify late and rare events. Achievement of improved design, conduct, and reporting of surgical research will need concerted action by editors, funders of health care and research, regulatory bodies, and professional societies.
Barkun JS, Aronson JK, Feldman LS, et al., 2009, Evaluation and stages of surgical innovations., Lancet, Vol: 374, Pages: 1089-1096
Surgical innovation is an important part of surgical practice. Its assessment is complex because of idiosyncrasies related to surgical practice, but necessary so that introduction and adoption of surgical innovations can derive from evidence-based principles rather than trial and error. A regulatory framework is also desirable to protect patients against the potential harms of any novel procedure. In this first of three Series papers on surgical innovation and evaluation, we propose a five-stage paradigm to describe the development of innovative surgical procedures.
Mazaris EM, Warrens AW, Smith G, et al., 2009, LIVE DONOR KIDNEY TRANSPLANTATION (LDKT): ATITUDES OF HEALTHCARE PROFESSIONALS AND PATIENTS TOWARDS ELDERLY AND MARGINAL DONORS, TRANSPLANT INTERNATIONAL, Vol: 22, Pages: 228-228, ISSN: 0934-0874
McLaughlin SD, Clark SK, Thomas-Gibson S, et al., 2009, Guide to Endoscopy of the Ileo-anal Pouch Following Restorative Proctocolectomy with Ileal Pouch-anal Anastomosis; Indications, Technique, and Management of Common Findings, INFLAMMATORY BOWEL DISEASES, Vol: 15, Pages: 1256-1263, ISSN: 1078-0998
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- Citations: 30
Tilney H, Lovegrove RE, Smith JJ, et al., 2009, The National Bowel Cancer Project: Social Deprivation Is an Independent Predictor of Nonrestorative Rectal Cancer Surgery, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 1046-1053, ISSN: 0012-3706
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- Citations: 14
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