Publications
419 results found
von Roon AC, Tekkis PP, Lovegrove RE, et al., 2008, Comparison of outcomes of ileal pouch-anal anastomosis for familial adenomatous polyposis with and without previous ileorectal anastomosis, Meeting of the Association-of-Coloproctology-of-Great-Britain-and-Ireland, Pages: 494-498
Background: It is reported that previous colectomy and ileorectal anastomosis (IRA) has no effect on postoperative complications and functional outcomes of secondary proctectomy and Real pouch-anal anastomosis (IPAA) in patients with familial adenomatous polyposis (FAP). This retrospective study re-examined the question in a single centre.Methods: Some 185 patients were grouped by either IPAA as the initial prophylactic surgical procedure (primary IPAA) or IPAA preceded by IRA (secondary IPAA). Data on functional outcomes were available for 104, 83 and 56 patients at years 1, 5 and 10 respectively.Results: The 78 patients who had secondary IPAA were older at the time of operation than the 107 who underwent primary IPAA (35.7 versus 29.2 years; P < 0.001). Six (8 per cent) of the secondary IPAA procedures could not be completed. Otherwise, apart from more wound infections in the secondary IPAA group (9 versus 0.9 per cent in the primary IPAA group; P = 0.012), there were no significant differences in rates of complications, functional outcomes, desmoid disease or pouch failure.Conclusion: Conversion from IRA to IPAA may not be possible in patients with FAP. Where conversion is successful, pouch outcomes are similar but wound infections are more frequent.
von Roon AC, Tekkis PP, Lovegrove RE, et al., 2008, Comparison of outcomes of ileal pouch-anal anastomosis for familial adenomatous polyposis with and without previous ileorectal anastomosis, BRITISH JOURNAL OF SURGERY, Vol: 95, Pages: 494-498, ISSN: 0007-1323
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- Citations: 15
McLaughlin SD, Petrovska L, Walker A, et al., 2008, Dysbiosis and pouchitis, evidence from 16srrna sequencing, GASTROENTEROLOGY, Vol: 134, Pages: A103-A103, ISSN: 0016-5085
Ngo N-T, Tan E, Tekkis PP, et al., 2008, Differential expression of p53 and P504s in sessile serrated polyps and traditional serrated adenomas as markers of malignant potential, GASTROENTEROLOGY, Vol: 134, Pages: A448-A448, ISSN: 0016-5085
Reese GE, East JE, Tan E, et al., 2008, Diagnostic precision of narrow band Imaging (NBI) versus chromoendoscopy for lesion characterization at colonoscopy: A meta analysis, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A192-A192
Reese GE, East JE, Tan E, et al., 2008, Diagnostic precision of narrow band imaging (NBI) versus chromoendoscopy for lesion characterization at colonoscopy: A meta analysis, GASTROENTEROLOGY, Vol: 134, Pages: A192-A192, ISSN: 0016-5085
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- Citations: 1
McLaughlin SD, Johnson MW, Clark SK, et al., 2008, Vsl#3 for chronic pouchitis; Experience in UK clinical practice, GASTROENTEROLOGY, Vol: 134, Pages: A711-A711, ISSN: 0016-5085
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- Citations: 8
McLaughlin SD, Clark SK, Bell AJ, et al., 2008, Incidence and implications of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A403-A403
Appau KA, Fazio VW, Church JM, et al., 2008, Use of infliximab within three months prior to ileocolonic resection is associated with significant adverse postoperative outcomes in Crohn's patients, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A857-A857
McLaughlin SD, Bell AJ, Postgate A, et al., 2008, Missed Crohn's disease is unlikely as a cause of unexplained iron deficiency in pouch patients: Evidence from video capsule endoscopy, GASTROENTEROLOGY, Vol: 134, Pages: A403-A404, ISSN: 0016-5085
McLaughlin SD, Bell AJ, Clark SK, et al., 2008, Combined ciprofloxacin and metronidazole is highly effective for the treatment of pre-pouch ileitis following restorative proctocolectomy, GASTROENTEROLOGY, Vol: 134, Pages: A529-A529, ISSN: 0016-5085
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- Citations: 1
Tan E, Lee SL, Gedroyc W, et al., 2008, Functional magnetic resonance imaging of the pelvic floor: Dynamic pressure and morphological changes in the levator am muscle on straining demonstrated by MR-Assisted biomechanical modelling, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A48-A48
McLaughlin SD, Bell AJ, Postgate A, et al., 2008, Missed Crohn's disease is unlikely as a cause of unexplained iron deficiency in pouch patients: Evidence from video capsule endoscopy, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A403-A404
Cornish JA, Wooding K, Tan E, et al., 2008, A study of quality of life, sexual, urinary and faecal function in females following restorative proctocolectomy, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A638-A638
McLaughlin SD, Clark SK, Bell AJ, et al., 2008, Incidence and implications of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis, GASTROENTEROLOGY, Vol: 134, Pages: A403-A403, ISSN: 0016-5085
Cornish JA, Wooding K, Tan E, et al., 2008, A study of quality of life, sexual, urinary and faecal function in females following restorative proctocolectomy, GASTROENTEROLOGY, Vol: 134, Pages: A638-A638, ISSN: 0016-5085
Appau KA, Fazio VW, Church JM, et al., 2008, Use of infliximab within three months prior to ileocolonic resection is associated with significant adverse postoperative outcomes in Crohn's patients, GASTROENTEROLOGY, Vol: 134, Pages: A857-A857, ISSN: 0016-5085
Cornish JA, Lovegrove R, Singh B, et al., 2008, Management of female fertility and pregnancy following restorative proctocolectomy, GASTROENTEROLOGY, Vol: 134, Pages: A638-A638, ISSN: 0016-5085
McLaughlin SD, Johnson MW, Clark SK, et al., 2008, Vsl#3 for chronic pouchitis; Experience in UK clinical practice, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A711-A711
Tan E, Lee S-L, Gedroyc W, et al., 2008, Functional magnetic resonance imaging of the pelvic floor: Dynamic pressure and morphological changes in the levator ani muscle on straining demonstrated by MR-assisted biomechanical modelling, GASTROENTEROLOGY, Vol: 134, Pages: A48-A48, ISSN: 0016-5085
Weston-Petrides GK, Lovegrove RE, Tilney HS, et al., 2008, Comparison of outcomes after restorative proctocolectomy with or without defunctioning ileostomy, ARCHIVES OF SURGERY, Vol: 143, Pages: 406-412, ISSN: 0004-0010
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- Citations: 125
McLaughlin SD, Bell AJ, Clark SK, et al., 2008, Combined ciprofloxacin and metronidazole is highly effective for the treatment of pre-pouch ileitis following restorative proctocolectomy, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A529-A529
McLaughlin SD, Perry-Woodford ZL, Johnson MW, et al., 2008, High incidence of osteoporosis in patients over 50 following restorative proctocolectomy suggests need for routine dxa screening, GASTROENTEROLOGY, Vol: 134, Pages: A641-A641, ISSN: 0016-5085
Cornish JA, Lovegrove R, Singh B, et al., 2008, Management of female fertility and pregnancy following restorative proctocolectomy, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A638-A638
McLaughlin SD, Perry-Woodford ZL, Johnson MW, et al., 2008, High incidence of osteoporosis in patients over 50 following restorative Proctocolectomy suggests need for routine DXA screening, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A641-A641
Rasheed S, Bowley DM, Aziz O, et al., 2008, Can depth of tumour invasion predict lymph node positivity in patients undergoing resection for early rectal cancer? A comparative study between T1 and T2 cancers, COLORECTAL DISEASE, Vol: 10, Pages: 231-237, ISSN: 1462-8910
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- Citations: 65
Heriot AG, Tekkis PP, 2008, Nodal harvest: Surgeon or pathologist? Reply, DISEASES OF THE COLON & RECTUM, Vol: 51, Pages: 368-368, ISSN: 0012-3706
Prabhudesai SG, Gould S, Rekhraj S, et al., 2008, Artificial neural networks: Useful aid in diagnosing acute appendicitis, WORLD JOURNAL OF SURGERY, Vol: 32, Pages: 305-309, ISSN: 0364-2313
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- Citations: 34
Garout M, Tilney HS, Tekkis PP, et al., 2008, Comparison of administrative data with the Association of Coloproctology of Great Britain and Ireland (ACPGBI) colorectal cancer database, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 23, Pages: 155-163, ISSN: 0179-1958
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- Citations: 46
Tilney HS, Heriot AG, Purkayastha S, et al., 2008, A national perspective on the decline of abdominoperineal resection for rectal cancer, Pages: 77-84, ISSN: 0003-4932
OBJECTIVE: To assess rates of abdominoperineal excision of the rectum (APER) for rectal cancer between centers and over time, and to evaluate the influence of patient characteristics, including social deprivation, on APER rate. METHODS: Data on patients undergoing APER or anterior resection (AR) in England were extracted from a national administrative database for the years 1996 to 2004. The primary outcome was the proportion of patients presenting with rectal cancer undergoing APER. Hierarchical logistic regression was used to identify independent factors associated with a nonrestorative resection. RESULTS: Data on 52,643 patients were analyzed, 13,109(24.9%) of whom underwent APER. The APER rate significantly reduced over the study period from 29.4% to 21.2% (P < 0.001). Operative mortality following AR decreased significantly during the period of study (5.1% to 4.2%, P = 0.002), while that following APER did not (P = 0.075). Male patients were more likely to undergo APER (P < 0.001), whereas those with an emergency presentation more commonly underwent AR (P < 0.001). Independent predictors of increased APER rate were male gender (odds ratio [OR] = 1.239, P < 0.001) and social deprivation (most vs. least deprived; OR = 1.589, P < 0.001), whereas increasing patient age (OR = 0.977, P = 0.027 per 10-year increase), year of study (2003/4 vs. 1996/7; OR = 0.646, P < 0.001) and initial presentation as an emergency (OR = 0.713, P < 0.001) were associated with lower APER rates. After accounting for case-mix, there was significant between-center variability in APER rates. CONCLUSION: Socially deprived patients were more likely to undergo abdominoperineal resection. Significant improvements in rates of nonrestorative resection were seen over time but although short-term outcomes following AR have improved, those following APER have not. Permanent stoma rates following rectal cancer surgery may be considered a surrogate marker of surgical quality. ©
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