Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2019:10.1007/s40521-019-00205-2,
author = {Patel, N and Vazquez-Ortiz, M and Turner, P},
doi = {10.1007/s40521-019-00205-2},
journal = {Current Treatment Options in Allergy},
pages = {164--174},
title = {Risk factors for adverse reactions during OIT},
url = {http://dx.doi.org/10.1007/s40521-019-00205-2},
volume = {6},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose of reviewOral immunotherapy (OIT) can have a major positive impact on patients with IgE-mediated food allergies, increasing reaction thresholds and reducing the need for dietary and lifestyle limitations. However, patients experience more frequent allergic reactions during OIT than when following dietary avoidance, and 10-75% of patients on OIT may experience anaphylaxis to treatment doses. Our ability to identify patients at higher risk of more severe or frequent reactions during OIT is limited. We review the current data available, and highlight the gaps in knowledge which impede our ability to predict response to treatment, occurrence of dose-related adverse events, and thus acceptance of OIT into wider clinical practice. Recent FindingsOur ability to predict the risk of severe reactions in food-allergic patients is limited, due to the multitude of allergen and host-related factors which influence this. While OIT is thought to reduce this risk, little is known about the immunomodulatory effect of OIT on these factors, and the resulting risk of allergic events during OIT. Several factors have been associated with reaction severity during OIT, and treatment withdrawals, including high allergen-specific IgE levels and certain IgE epitope binding patterns. Other factors proposed include the degree of sensitisation on skin testing, initial reaction threshold, prior reaction severity, age and concomitant allergic disease including allergic rhinitis and asthma. These have also been associated with more severe events in food-allergic patients not undergoing OIT, and suggest a specific patient phenotype prone to more severe and persistent food allergy, which also impact on poorer outcomes during OIT. Ironically, it is this patient phenotype who arguably has most to gain from OIT. SummaryOur understanding of the constellation of factors contributing to reaction threshold, nature and severity in food allergy is improving, and this helps understand the complexity of
AU  - Patel,N
AU  - Vazquez-Ortiz,M
AU  - Turner,P
DO  - 10.1007/s40521-019-00205-2
EP  - 174
PY  - 2019///
SN  - 2196-3053
SP  - 164
TI  - Risk factors for adverse reactions during OIT
T2  - Current Treatment Options in Allergy
UR  - http://dx.doi.org/10.1007/s40521-019-00205-2
UR  - http://hdl.handle.net/10044/1/69043
VL  - 6
ER  -
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