Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jackson:2020:cid/ciz719,
author = {Jackson, D and Pitcher, M and Hudson, C and Andrews, N and Southern, J and Ellis, J and Hoschler, K and Pebody, R and Turner, P and Miller, E and Zambon, M},
doi = {cid/ciz719},
journal = {Clinical Infectious Diseases},
pages = {2505--2513},
title = {Viral shedding in recipients of live attenuated influenza vaccine in the 2016/17 and 2017/18 influenza seasons in the United Kingdom},
url = {http://dx.doi.org/10.1093/cid/ciz719},
volume = {70},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Live attenuated influenza vaccine(LAIV) use inchildren was suspended in the USA due to an  apparentlack  of protection  against  (H1N1)pdm09  virusesin  the  2015/16  influenza season. The (H1N1)pdm09 vaccine strain was subsequently changed in 2017/18 to improve viral fitness. We conducted LAIV virus shedding studies to assess the effect of this change. Methods: Children aged2-18 yearswere recruited to receive quadrivalent LAIV in the 2016/17 (n=641) and 2017/18(n=362)influenza seasons. Viruses from nasal swabs taken 1, 3 and 6 days post-vaccination were quantified byreverse transcription-PCR and area under curve titres determined. Presence and quantity of shedding was compared between strains and seasons with adjustment for age and prior receipt of LAIV (n=436), inactivated seasonal (n=100) or (H1N1)pdm09 vaccine (n=166). Results: (H1N1)pdm09 detection (positivity) in 2016/17 and 2017/18 (11.2% and 3.9% respectively) was lower than that of H3N2 (19.7% and 18.7% respectively) and influenza B (28.9% and 33.9% respectively for B/Victoria). (H1N1)pdm09 positivity was significantly higher in 2016/17 than 2017/18 (p=0.005), butwithin participants that shed, the (H1N1)pdm09 titre increased in 2017/18  (p=0.02),  whereasH3N2  and  influenza  B  titres  were  similar  between  seasons. Positivity ratesdeclined with age and prior vaccination reduced the likelihood of shedding influenza B but not (H1N1)pdm09. Conclusions: The (H1N1)pdm09 titre increased in 2017/18, indicating more efficientvirusreplication in childrenthat shed virusthan the 2016/17 strain, although overall positivity was reduced. Age and prior vaccine receipt negatively correlated with shedding rates, therefore these factors require consideration when correlating virus shedding with clinical protection.
AU  - Jackson,D
AU  - Pitcher,M
AU  - Hudson,C
AU  - Andrews,N
AU  - Southern,J
AU  - Ellis,J
AU  - Hoschler,K
AU  - Pebody,R
AU  - Turner,P
AU  - Miller,E
AU  - Zambon,M
DO  - cid/ciz719
EP  - 2513
PY  - 2020///
SN  - 1058-4838
SP  - 2505
TI  - Viral shedding in recipients of live attenuated influenza vaccine in the 2016/17 and 2017/18 influenza seasons in the United Kingdom
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciz719
UR  - http://hdl.handle.net/10044/1/71650
VL  - 70
ER  -
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