Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Worm:2019:10.1007/s40629-019-00109-2,
author = {Worm, M and Hanschmann-Mohn, T and Scherer, Hofmeier K and Cardona, V and Turner, P and Dölle-Bierke, S},
doi = {10.1007/s40629-019-00109-2},
journal = {Allergo Journal International},
pages = {327--329},
title = {Drug-induced anaphylaxis—elicitors, mechanisms and diagnosis},
url = {http://dx.doi.org/10.1007/s40629-019-00109-2},
volume = {28},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Drugs are one of the major causes of anaphylaxis. For example 2346 cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs; n= 902) and antibiotics (n= 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been identified as a receptor for non-IgE-dependent mechanisms. Drug-induced anaphylaxis results more frequently in lethal reactions and is more commonly associated with cardiovascular symptoms. Also therapy refractory anaphylaxis is more frequently triggered by drugs. For the diagnosis of drug-induced anaphylaxis current national and international guidelines should be followed including provocation tests to avoid future reactions.
AU  - Worm,M
AU  - Hanschmann-Mohn,T
AU  - Scherer,Hofmeier K
AU  - Cardona,V
AU  - Turner,P
AU  - Dölle-Bierke,S
DO  - 10.1007/s40629-019-00109-2
EP  - 329
PY  - 2019///
SN  - 2197-0378
SP  - 327
TI  - Drug-induced anaphylaxis—elicitors, mechanisms and diagnosis
T2  - Allergo Journal International
UR  - http://dx.doi.org/10.1007/s40629-019-00109-2
UR  - https://link.springer.com/article/10.1007%2Fs40629-019-00109-2
UR  - http://hdl.handle.net/10044/1/74162
VL  - 28
ER  -
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