Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turner:2020:10.1016/j.jaip.2019.11.027,
author = {Turner, P and Campbell, DE and Motosue, MS and Campbell, RL},
doi = {10.1016/j.jaip.2019.11.027},
journal = {Journal of Allergy and Clinical Immunology: In Practice},
pages = {1169--1176},
title = {Global trends in anaphylaxis epidemiology and clinical implications},
url = {http://dx.doi.org/10.1016/j.jaip.2019.11.027},
volume = {8},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The true global scale of anaphylaxis remains elusive, because many episodes occur in the community without presentation to healthcare facilities, and most regions have not yet developed reliable systems with which to monitor severe allergic events. The most robust datasets currently available are based largely on hospital admissions, which are limited by inherent issues of misdiagnosis, misclassification and generalizability. Despite this, there is convincing evidence of a global increase in rates of all cause-anaphylaxis, driven largely by medication and food-related anaphylaxis. There is no evidence of parallel increases in global all-cause anaphylaxis mortality, with surprisingly similar estimates for case fatality rates at approximately 0.5-1% rate of fatal outcomes for hospitalizations due to anaphylaxis across several regions.Studying regional patterns of anaphylaxis to certain triggers have provided valuable insights into susceptibility and sensitizing events: for example, the link between the monoclonal antibody cetuximab and allergy to mammalian meat. Likewise, data from published fatality registers can identify potentially modifiable risk factors which can be used to inform clinical practice, such as prevention of delayed epinephrine administration, correct posturing during anaphylaxis, special attention to populations at risk (such as the elderly on multiple medications) and use of venom immunotherapy in individuals at risk of insect-related anaphylaxis.
AU  - Turner,P
AU  - Campbell,DE
AU  - Motosue,MS
AU  - Campbell,RL
DO  - 10.1016/j.jaip.2019.11.027
EP  - 1176
PY  - 2020///
SN  - 2213-2201
SP  - 1169
TI  - Global trends in anaphylaxis epidemiology and clinical implications
T2  - Journal of Allergy and Clinical Immunology: In Practice
UR  - http://dx.doi.org/10.1016/j.jaip.2019.11.027
UR  - https://www.sciencedirect.com/science/article/pii/S2213219819309675?via%3Dihub
UR  - http://hdl.handle.net/10044/1/75306
VL  - 8
ER  -
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