Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turner:2021:10.1136/archdischild-2020-319906,
author = {Turner, P and Patel, N and Vazquez-Ortiz, M and Campbell, DE and DunnGalvin, A and Turner, PJ},
doi = {10.1136/archdischild-2020-319906},
journal = {Archives of Disease in Childhood},
pages = {558--563},
title = {Self-administration of adrenaline for anaphylaxis during in-hospital food challenges improves health-related quality of life},
url = {http://dx.doi.org/10.1136/archdischild-2020-319906},
volume = {106},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective To assess the impact of anaphylaxis on health-related quality of life (HRQL) and self-efficacy in food-allergic patients undergoing in-hospital food challenge.Design Secondary analysis of a randomised controlled trial.Setting Specialist allergy centre.Patients Peanut-allergic young people aged 8–16 years.Interventions Double-blind, placebo-controlled food challenge to peanut, with HRQL and self-efficacy assessed using validated questionnaire, approximately 2 weeks prior to and 2 weeks after challenge. Where possible, anaphylaxis was treated with self-injected adrenaline (epinephrine).Main outcome measures Change in HRQL and self-efficacy.Results 56 participants had reactions at food challenge, of whom 16 (29%) had anaphylaxis. Overall, there was an improvement in HRQL (mean 2.6 points (95% CI 0.3 to 4.8); p=0.030) and self-efficacy (mean 4.1 points (95% CI 2.4 to 5.9); p<0.0001), independent of whether anaphylaxis occurred. Parents also reported improved HRQL (mean 10.3 points (95% CI 5.9 to 14.7); p<0.0001). We found evidence of discordance between the improvement in HRQL and self-efficacy as reported by young people and that perceived by parents in their child.Conclusions Anaphylaxis at food challenge, followed by self-administration of injected adrenaline, was associated with an increase in HRQL and self-efficacy in young people with peanut allergy. We found no evidence that the occurrence of anaphylaxis had a detrimental effect. Young people should be encouraged to self-administer adrenaline using their autoinjector device to treat anaphylaxis at in-hospital challenge.Trial registration number NCT02149719
AU  - Turner,P
AU  - Patel,N
AU  - Vazquez-Ortiz,M
AU  - Campbell,DE
AU  - DunnGalvin,A
AU  - Turner,PJ
DO  - 10.1136/archdischild-2020-319906
EP  - 563
PY  - 2021///
SN  - 0003-9888
SP  - 558
TI  - Self-administration of adrenaline for anaphylaxis during in-hospital food challenges improves health-related quality of life
T2  - Archives of Disease in Childhood
UR  - http://dx.doi.org/10.1136/archdischild-2020-319906
UR  - http://hdl.handle.net/10044/1/81865
VL  - 106
ER  -
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