Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sahiner:2021:10.1111/all.14776,
author = {Sahiner, UM and Layhadi, JA and Golebski, K and István, Komlósi Z and Peng, Y and Sekerel, B and Durham, SR and Brough, H and Morita, H and Akdis, M and Turner, P and Nadeau, K and Spits, H and Akdis, C and Shamji, MH},
doi = {10.1111/all.14776},
journal = {Allergy},
title = {Innate Lymphoid Cells: The Missing Part Of A Puzzle In Food Allergy.},
url = {http://dx.doi.org/10.1111/all.14776},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Food allergy is an increasingly prevalent disease which is mainly driven by uncontrolled type 2 immune response. Currently, knowledge about the underlying mechanisms that initiate and promote the immune response to dietary allergens is limited. Patients with food allergy are commonly sensitized through the skin in their early life, later on developing allergy symptoms within the gastrointestinal tract. Food allergy results from a dysregulated type 2 response to food allergens, characterized by enhanced levels of IgE, IL-4, IL-5 and IL-13 with infiltration of mast cells, eosinophils and basophils. Recent studies raised a possible role for the involvement of innate lymphoid cells (ILCs) in driving food allergy. They represent a group of lymphocytes that lack specific, recombined antigen receptors. ILCs contribute to immune responses not only by releasing cytokines and other mediators but also by responding to cytokines produced by activated cells in their local microenvironment. Due to their localization at barrier surfaces ofthe airways, gut and skin, ILCs form a link between the innate and adaptive immunity. This review summarizes recent evidence on how skin and gastrointestinal mucosal immune system contribute to both homeostasis and the development of food allergy, as well as the involvement of ILCs towards inflammatory processes and regulatory mechanisms.
AU  - Sahiner,UM
AU  - Layhadi,JA
AU  - Golebski,K
AU  - István,Komlósi Z
AU  - Peng,Y
AU  - Sekerel,B
AU  - Durham,SR
AU  - Brough,H
AU  - Morita,H
AU  - Akdis,M
AU  - Turner,P
AU  - Nadeau,K
AU  - Spits,H
AU  - Akdis,C
AU  - Shamji,MH
DO  - 10.1111/all.14776
PY  - 2021///
TI  - Innate Lymphoid Cells: The Missing Part Of A Puzzle In Food Allergy.
T2  - Allergy
UR  - http://dx.doi.org/10.1111/all.14776
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33583026
ER  -
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