Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turner:2021:10.1111/cea.13865,
author = {Turner, P and Ruiz-Garcia, M and Patel, N and Abrantes, G and Burrell, S and Vazquez-Ortiz, M and Skypala, I and Durham, S and Boyle, R},
doi = {10.1111/cea.13865},
journal = {Clinical and Experimental Allergy},
pages = {696--702},
title = {Delayed symptoms and orthostatic intolerance following peanut challenge},
url = {http://dx.doi.org/10.1111/cea.13865},
volume = {51},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundClinical reactions to Oral Food Challenge (OFC) in peanutallergic individuals have been wellcharacterised, but rates and phenotypes of symptom recurrence beyond the first hour after objective symptoms are less wellcharacterised.ObjectiveTo evaluate the rate of newonset symptoms occurring at least 1 h after stopping OFC in peanutallergic children and adults undergoing peanutOFC.MethodsWe prospectively collected data relating to adverse events following positive reactions at doubleblind, placebocontrolled food challenges (DBPCFC) to peanut in children and adults evaluated for eligibility to participate in two clinical trials (NCT02149719, NCT02665793). The trials included people aged 8 to 45 with primary, IgEmediated peanut allergy at DBPCFC. The challenge protocol included consumption of a light meal 1 h after reaction.ResultsA total of 121 participants (64 children, 57 adults) had immediate, objective symptoms at DBPCFC, 25 (17 children, 8 adults) with anaphylaxis. Thirtythree (27%) had progression or recurrence of symptoms ≥ 1 h after objective clinical reaction, of whom 8 developed anaphylaxis. In 23 cases, the onset of new symptoms was associated with consumption of a light meal. In eight cases, symptoms were limited to a symptomatic postural fall in blood pressure noted in preparation for discharge, without any other new features of an allergic reaction.Conclusions & Clinical RelevanceProgressive or newonset symptoms ≥1 h following initial allergic reaction at OFC are common and can include orthostatic hypotension. Recurrent symptoms may be temporally associated with food consumption.
AU  - Turner,P
AU  - Ruiz-Garcia,M
AU  - Patel,N
AU  - Abrantes,G
AU  - Burrell,S
AU  - Vazquez-Ortiz,M
AU  - Skypala,I
AU  - Durham,S
AU  - Boyle,R
DO  - 10.1111/cea.13865
EP  - 702
PY  - 2021///
SN  - 0954-7894
SP  - 696
TI  - Delayed symptoms and orthostatic intolerance following peanut challenge
T2  - Clinical and Experimental Allergy
UR  - http://dx.doi.org/10.1111/cea.13865
UR  - http://hdl.handle.net/10044/1/88484
VL  - 51
ER  -
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