Imperial College London
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Dr Paul Turner

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy & Clinical Immunology
 
 
 
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Contact

 

+44 (0)20 3312 7754p.turner

 
 
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Location

 

Children's Clinical Research FacilityCambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nagendran:2022:10.1080/1744666X.2022.2053675,
author = {Nagendran, S and Patel, N and Turner, P},
doi = {10.1080/1744666X.2022.2053675},
journal = {Expert Review of Clinical Immunology},
pages = {363--376},
title = {Oral immunotherapy for food allergy in children: is it worth it?},
url = {http://dx.doi.org/10.1080/1744666X.2022.2053675},
volume = {18},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction:Oral immunotherapy (OIT) is effective at inducing desensitization in food-allergic individuals, and is a valid therapeutic option for those allergic to peanut, cow’s milk and egg. However, there is a high rate of dose-related adverse events, and at least one fatality to OIT has been reported.Areas covered:We provide an update on the broader framework of issues which will impact on the availability and uptake of OIT.Expert opinion:The need for standardized products remains controversial. A licensed product exists for peanut-OIT, but OIT can also be safely achieved using peanut-containing foods at much lower cost. For other allergens, OIT can only be done with non-pharma products – something which has been done safely for over 2 decades. There is a need to develop personalized protocols for OIT, particularly for the 20% of patients unable to tolerate standard OIT. Cost-effectiveness is dependent on improved quality of life, but evidence for this is currently lacking, and is a key evidence gap. OIT is likely to be cost-effective, particularly if noncommercial products are used. There may be a trade-off: in patients with lower reaction thresholds, a commercial product may be needed for initial updosing, until a level of desensitization is achieved when they can be switched to natural food products.
AU  - Nagendran,S
AU  - Patel,N
AU  - Turner,P
DO  - 10.1080/1744666X.2022.2053675
EP  - 376
PY  - 2022///
SN  - 1744-666X
SP  - 363
TI  - Oral immunotherapy for food allergy in children: is it worth it?
T2  - Expert Review of Clinical Immunology
UR  - http://dx.doi.org/10.1080/1744666X.2022.2053675
UR  - http://hdl.handle.net/10044/1/96145
VL  - 18
ER  -
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