Imperial College London

Emeritus ProfessorPeterTyrer

Faculty of MedicineDepartment of Brain Sciences

Emeritus Professor in Community Psychiatry - Clinical



+44 (0)20 3313 4161p.tyrer




13.09Claybrook CentreCharing Cross Campus






BibTex format

author = {Sanatinia, R and Wang, D and Tyrer, P and Tyrer, H and Crawford, M and Cooper, S and Loebenberg, G and Barrett, B},
doi = {10.1192/bjp.bp.115.173526},
journal = {British Journal of Psychiatry},
pages = {244--250},
title = {Impact of personality status on the outcomes and cost of cognitive–behavioural therapy for health anxiety},
url = {},
volume = {209},
year = {2016}

RIS format (EndNote, RefMan)

AB - BACKGROUND: Health anxiety, hypochondriasis and personality disturbance commonly coexist. The impact of personality status was assessed in a secondary analysis of a randomised controlled trial (RCT). AIMS: To test the impact of personality status using ICD-11 criteria on the clinical and cost outcomes of treatment with cognitive-behavioural therapy for health anxiety (CBT-HA) and standard care over 2 years. METHOD: Personality dysfunction was assessed at baseline in 444 patients before randomisation and independent assessment of costs and outcomes made on four occasions over 2 years. RESULTS: In total, 381 patients (86%) had some personality dysfunction with 184 (41%) satisfying the ICD criteria for personality disorder. Those with no personality dysfunction showed no treatment differences (P = 0.90) and worse social function with CBT-HA compared with standard care (P<0.03) whereas all other personality groups showed greater improvement with CBT-HA maintained over 2 years (P<0.001). Less benefit was shown in those with more severe personality disorder (P<0.05). Costs were less with CBT-HA except for non-significant greater differences in those with moderate or severe personality disorder. CONCLUSIONS: The results contradict the hypothesis that personality disorder impairs response to CBT in health anxiety in both the short and medium term.
AU - Sanatinia,R
AU - Wang,D
AU - Tyrer,P
AU - Tyrer,H
AU - Crawford,M
AU - Cooper,S
AU - Loebenberg,G
AU - Barrett,B
DO - 10.1192/bjp.bp.115.173526
EP - 250
PY - 2016///
SN - 1472-1465
SP - 244
TI - Impact of personality status on the outcomes and cost of cognitive–behavioural therapy for health anxiety
T2 - British Journal of Psychiatry
UR -
UR -
VL - 209
ER -