Imperial College London

Emeritus ProfessorPeterTyrer

Faculty of MedicineDepartment of Medicine

Emeritus Professor in Community Psychiatry - Clinical
 
 
 
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Contact

 

+44 (0)20 3313 4161p.tyrer

 
 
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Location

 

13.09Claybrook CentreCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
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580 results found

Tyrer P, Mulder R, Kim Y-R, Crawford MJet al., 2019, The Development of the ICD-11 Classification of Personality Disorders: An Amalgam of Science, Pragmatism, and Politics., Annu Rev Clin Psychol

The nomenclature of personality disorders in the 11th revision of the International Classification of Diseases and Related Health Problems represents the most radical change in the classification history of personality disorders. A dimensional structure now replaces categorical description. It was argued by the Working Group that only a dimensional system was consistent with the empirical evidence and, in the spirit of clinical utility, the new system is based on two steps. The first step is to assign one of five levels of severity, and the second step is to assign up to five prominent domain traits. There was resistance to this structure from those who feel that categorical diagnosis, particularly of borderline personality disorder, should be retained. After lengthy discussion, described in detail here, there is now an option for a borderline pattern descriptor to be selected as a diagnostic option after severity has been determined. Expected final online publication date for the Annual Review of Clinical Psychology Volume 15 is May 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Mulder R, Tyrer P, 2018, Diagnosis and classification of personality disorders, Current Opinion in Psychiatry, Pages: 1-1, ISSN: 0951-7367

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Crawford MJ, Sanatinia R, Barrett B, Cunningham G, Dale O, Ganguli P, Lawrence-Smith G, Leeson V, Lemonsky F, Lykomitrou G, Montgomery AA, Morriss R, Munjiza J, Paton C, Skorodzien I, Singh V, Tan W, Tyrer P, Reilly JGet al., 2018, The Clinical Effectiveness and Cost-Effectiveness of Lamotrigine in Borderline Personality Disorder: A Randomized Placebo-Controlled Trial, AMERICAN JOURNAL OF PSYCHIATRY, Vol: 175, Pages: 756-764, ISSN: 0002-953X

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Tyrer P, 2018, Recent Advances in the Understanding and Treatment of Health Anxiety, Current Psychiatry Reports, Vol: 20, ISSN: 1523-3812

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Tyrer P, 2018, The Importance of Nidotherapy and Environmental Change in the Management of People with Complex Mental Disorders., Int J Environ Res Public Health, Vol: 15

Much has been done in the last 50 years to achieve a better understanding of the psychosocial causes and other factors influencing the manifestation of mental illness, but there has been a conspicuous omission. Although gross environmental deficiencies were exposed in old mental institutions, 70 years ago the more subtle maladaptive settings that reinforce chronicity in mental illness have often been forgotten. In this review, the potential of systematic environmental manipulation as a treatment (nidotherapy) and other similar forms of management, used many times in the past but now mainly in forensic settings, is examined. There is now accumulating evidence, reinforced by controlled trials, that planned environmental change, preferably carried out with the full cooperation of the patient, can be a major contributor to therapeutic benefit. It is also very cost-effective. All forms of the environment, physical, social and personal, can be addressed in making assessments, and once a planned way forward has been chosen, progress can be monitored by personnel with limited mental health experience. These interventions have applications in general mental health and occupational health services and deserve much wider use.

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Crawford MJ, Sanatinia R, Barrett B, Cunningham G, Dale O, Ganguli P, Lawrence-Smith G, Leeson VC, Lemonsky F, Lykomitrou-Matthews G, Montgomery A, Morriss R, Munjiza J, Paton C, Skorodzien I, Singh V, Tan W, Tyrer P, Reilly JGet al., 2018, Lamotrigine for people with borderline personality disorder: a RCT, HEALTH TECHNOLOGY ASSESSMENT, Vol: 22, Pages: 1-+, ISSN: 1366-5278

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Olajide K, Munjiza J, Moran P, O'Connell L, Newton-Howes G, Bassett P, Akintomide G, Ng N, Tyrer P, Mulder R, Crawford MJet al., 2018, DEVELOPMENT AND PSYCHOMETRIC PROPERTIES OF THE STANDARDIZED ASSESSMENT OF SEVERITY OF PERSONALITY DISORDER (SASPD), JOURNAL OF PERSONALITY DISORDERS, Vol: 32, Pages: 44-56, ISSN: 0885-579X

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Tyrer P, Tyrer H, 2018, Health anxiety: detection and treatment, BJPsych Advances, Vol: 24, Pages: 66-72, ISSN: 2056-4678

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Tyrer P, 2017, Borderline hits the diagnostic buffers again, BIPOLAR DISORDERS, Vol: 19, Pages: 599-600, ISSN: 1398-5647

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Tyrer P, Salkovskis P, Tyrer H, Wang D, Crawford MJ, Dupont S, Cooper S, Green J, Murphy D, Smith G, Bhogal S, Nourmand S, Lazarevic V, Loebenberg G, Evered R, Kings S, McNulty A, Lisseman-Stones Y, McAllister S, Kramo K, Nagar J, Reid S, Sanatinia R, Whittamore K, Walker G, Philip A, Warwick H, Byford S, Barrett Bet al., 2017, Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years, HEALTH TECHNOLOGY ASSESSMENT, Vol: 21, Pages: 1-+, ISSN: 1366-5278

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Singh SP, Paul M, Parsons H, Burns T, Tyrer P, Fazel S, Deb S, Islam Z, Rugkasa J, Gajwani R, Thana L, Crawford MJet al., 2017, A prospective, quantitative study of mental health act assessments in England following the 2007 amendments to the 1983 act: did the changes fulfill their promise?, BMC PSYCHIATRY, Vol: 17, ISSN: 1471-244X

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Tyrer P, Tarabi SA, Bassett P, Liedtka N, Hall R, Nagar J, Imrie A, Tyrer Het al., 2017, Nidotherapy compared with enhanced care programme approach training for adults with aggressive challenging behaviour and intellectual disability (NIDABID): cluster-randomised controlled trial, Journal of Intellectual Disability Research, Vol: 61, Pages: 521-531, ISSN: 0964-2633

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Tyrer P, Tyrer H, Morriss R, Crawford M, Cooper S, Yang M, Guo B, Mulder RT, Kemp S, Barrett Bet al., 2017, Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial, OPEN HEART, Vol: 4, ISSN: 2053-3624

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Sanatinia R, Wang D, Tyrer P, Tyrer H, Crawford M, Cooper S, Loebenberg G, Barrett Bet al., 2016, Impact of personality status on the outcomes and cost of cognitive-behavioural therapy for health anxiety, BRITISH JOURNAL OF PSYCHIATRY, Vol: 209, Pages: 244-250, ISSN: 0007-1250

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Olajide K, Tyrer P, Singh SP, Burns T, Rugkasa J, Thana L, Paul M, Islam Z, Crawford MJet al., 2016, Likelihood and predictors of detention in patients with personality disorder compared with other mental disorders: A retrospective, quantitative study of Mental Health Act assessments, PERSONALITY AND MENTAL HEALTH, Vol: 10, Pages: 191-204, ISSN: 1932-8621

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Tyrer P, Wang D, Tyrer H, Crawford M, Cooper Set al., 2016, Dimensions of dependence and their influence on the outcome of cognitive behaviour therapy for health anxiety: randomized controlled trial, PERSONALITY AND MENTAL HEALTH, Vol: 10, Pages: 96-105, ISSN: 1932-8621

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Kim Y-R, Tyrer P, Lee H-S, Kim S-G, Connan F, Kinnaird E, Olajide K, Crawford Met al., 2016, Schedule for personality assessment from notes and documents (SPAN-DOC): Preliminary validation, links to the ICD-11 classification of personality disorder, and use in eating disorders, PERSONALITY AND MENTAL HEALTH, Vol: 10, Pages: 106-117, ISSN: 1932-8621

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Tyrer P, Crawford M, Mulder R, Clark L-Aet al., 2016, THE ADVANTAGES OF A SIMPLIFIED CLASSIFICATION OF PERSONALITY DISORDER IN INTERNATIONAL CLASSIFICATION OF DISEASES-11 REVISION, AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, Vol: 50, Pages: 5-5, ISSN: 0004-8674

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Tyrer P, Eilenberg T, Fink P, Hedman E, Tyrer Het al., 2016, Health anxiety: the silent, disabling epidemic, BMJ, Pages: i2250-i2250

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Tyrer P, Nagar J, Evans R, Oliver P, Bassett P, Liedtka N, Tarabi Aet al., 2016, The Problem Behaviour Checklist: short scale to assess challenging behaviours, BJPsych Open, Vol: 2, Pages: 45-49

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Tyrer P, Tyrer H, Guo B, 2016, The General Neurotic Syndrome: A Re-Evaluation, Psychotherapy and Psychosomatics, Vol: 85, Pages: 193-197, ISSN: 0033-3190

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Tyrer P, Tyrer H, Cooper S, Barrett B, Kings S, Lazarevic V, Bransby-Adams K, Whittamore K, Walker G, McNulty A, Donaldson E, Midgley L, McCoy S, Evered R, Yang M, Guo B, Lisseman-Stones Y, Doukani A, Mulder R, Morriss R, Crawford Met al., 2015, Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation., BMC Psychol, Vol: 3

BACKGROUND: Most patients with chest pain have nothing wrong with their cardiac function. Psychological forms of treatment for this condition are more likely to be successful than others. METHODS/DESIGN: A two-arm parallel controlled randomized trial of standard care versus a modified form of cognitive behaviour therapy for chest pain (CBT-CP) in patients who have attended emergency hospital services. Inclusion criteria include (i) emergency attendance more than once in the previous year with chest pain when no physical pathology has been found, (ii) aged between 16 and 75, (iii) signed consent to take part in the study. Exclusion criteria are (i) under current psychiatric care, (ii) those who have had new psychotropic drugs prescribed within the last two months, (iii) are receiving or about to receive a formal psychological treatment. Those satisfying these criteria will be randomized to 4-10 sessions of CBT-CP or to continue with standard care. Participants are randomized using a remote web-based system using permuted stacked blocks stratified by study centre. Assessment is carried out at baseline by researchers subsequently masked to allocation and at 6 months and 1 year after randomization. The primary outcome is the Health Anxiety Inventory score at 6 months, and secondary outcomes are generalised anxiety and depressive symptoms, the Lucock Health Anxiety Questionnaire adapted for chest pain, visual analogue scales for chest pain and discomfort (Inskip Scale), the Schedule for Evaluating Persistent Symptoms (SEPS), health related quality of life, social functioning and medical resource usage. Intention to treat analyses will be carried out with clinical and functioning data, and a cost-utility analysis will compare differences in total costs and differences in quality of life using QALYs derived from the EQ-5D. The data will also be linked to another parallel study in New Zealand where 126 patients with the same inclusion criteria have been treated in a similar

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Tyrer P, Tyrer H, 2015, Nidotherapy: The expansion of environmental treatment, Australian & New Zealand Journal of Psychiatry, Vol: 49, Pages: 934-934, ISSN: 0004-8674

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Crawford MJ, Sanatinia R, Barrett B, Byford S, Cunningham G, Gakhal K, Lawrence-Smith G, Leeson V, Lemonsky F, Lykomitrou G, Montgomery A, Morriss R, Paton C, Tan W, Tyrer P, Reilly JGet al., 2015, Lamotrigine versus inert placebo in the treatment of borderline personality disorder: study protocol for a randomized controlled trial and economic evaluation, TRIALS, Vol: 16, ISSN: 1745-6215

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Newton-Howes G, Mulder R, Tyrer P, 2015, Diagnostic neglect: the potential impact of losing a separate axis for personality disorder, BRITISH JOURNAL OF PSYCHIATRY, Vol: 206, Pages: 355-356, ISSN: 0007-1250

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Tyrer P, Duggan C, Cooper S, Tyrer H, Swinson N, Rutter Det al., 2015, The lessons and legacy of the programme for dangerous and severe personality disorders, PERSONALITY AND MENTAL HEALTH, Vol: 9, Pages: 96-106, ISSN: 1932-8621

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Tyrer H, Tyrer P, Lisseman-Stones Y, McAllister S, Cooper S, Salkovskis P, Crawford MJ, Dupont S, Green J, Murphy D, Wang Det al., 2015, Therapist differences in a randomised trial of the outcome of cognitive behaviour therapy for health anxiety in medical patients, INTERNATIONAL JOURNAL OF NURSING STUDIES, Vol: 52, Pages: 686-694, ISSN: 0020-7489

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Tyrer P, Reed GM, Crawford MJ, 2015, Classification, assessment, prevalence, and effect of personality disorder, LANCET, Vol: 385, Pages: 717-726, ISSN: 0140-6736

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Crawford MJ, Sanatinia R, Barrett B, Byford S, Dean M, Green J, Jones R, Leurent B, Sweeting MJ, Touquet R, Greene L, Tyrer P, Ward H, Lingford-Hughes Aet al., 2015, The clinical and cost-effectiveness of brief advice for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial, SEXUALLY TRANSMITTED INFECTIONS, Vol: 91, Pages: 37-43, ISSN: 1368-4973

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Tyrer P, 2015, Personality dysfunction is the cause of recurrent non-cognitive mental disorder: A testable hypothesis, Personality and Mental Health, Vol: 9, Pages: 1-7, ISSN: 1932-8621

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