Publications
655 results found
TYRER PJ, 1987, MEASUREMENT OF ABNORMAL-PERSONALITY - A REVIEW, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 80, Pages: 637-639, ISSN: 0141-0768
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- Citations: 5
Tyrer P, 1987, Relationship between neurotic symptoms and neurotic diagnosis: a longitudinal study, Journal of Affective Disorders, Vol: 13, Pages: 13-21, ISSN: 0165-0327
Tyrer P, Remington M, Alexander J, 1987, The outcome of neurotic disorders after out-patient and day hospital care., Br J Psychiatry, Vol: 151, Pages: 57-62, ISSN: 0007-1250
New psychiatric out-patients with depressive, phobic, and anxiety neurosis were randomly allocated to out-patient care or to one of two types of day hospital treatment, one specialising in psychotherapy and the other offering all forms of day care. Of 106 patients who entered the study, 78 had assessments of psychiatric symptomatology and social adjustment both before treatment and after 4, 8 and 24 months. There was no significant difference in outcome between depressive, phobic, and anxiety neurosis, and no overall difference in response to treatment between the three types of care. Suicidal symptoms were significantly less common in out-patients. In many respects, neurotic disorder can be regarded as a single syndrome.
TYRER PJ, 1987, THE PLACE OF BENZODIAZEPINES IN THE TREATMENT OF ANXIETY - IMPLICATIONS OF RECENT RESEARCH FOR CLINICAL-PRACTICE, INTEGRATIVE PSYCHIATRY, Vol: 5, Pages: 113-115, ISSN: 0735-3847
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- Citations: 2
Tyrer P, Ferguson B, 1987, Problems in the classification of personality disorder, Psychological Medicine, Vol: 17, Pages: 15-20, ISSN: 0033-2917
Tyrer P, Marsden CA, Casey P, et al., 1987, Clinical efficacy of paroxetine in resistant depression., J Psychopharmacol, Vol: 1, Pages: 251-257, ISSN: 0269-8811
The antidepressant effects of a specific reuptake inhibitor of 5-hydroxytryptamine (5-HT), paroxetine, were tested in 24 patients with resistant depression who had failed to respond to conventional antidepressants after at least 4 weeks of treatment. A novel exper imental design was chosen in which all patients had 12 weeks of treatment beginning and ending with placebo therapy with 6 weeks of active drug treatment at some point in between. Ratings of depressive symptoms were made using the Hamilton rating scale (HRS) for depression, and the checklist for unwanted effects and their severity was also recorded before and during treatment at 2 week intervals. The change from placebo to active paroxetine therapy was made using a double-blind procedure. Patients who made a significant placebo response in the first 2 weeks of treatment were excluded from further analysis; 20 patients completed the study and satisfied all criteria for inclusion. Both groups of showed a significant improvement in symptoms after 4 weeks of paroxetine therapy. There were no significant treatment differences between the groups, but improvement in symptoms occurred sig nificantly later in the patients who had a longer period of initial placebo therapy. The experimental design also allowed study of withdrawal effects after stopping active treatment. There was no increase in adverse effects, including a subgroup associated with withdrawal problems, either during treatment with paroxetine or after the drug was stopped. The results suggest that paroxetine is probably an effective antidepressant, is well tolerated and has few adverse effects.
TYRER PJ, 1987, WHAT DO BETA-BLOCKERS TELL US ABOUT ANXIETY, INTERNATIONAL JOURNAL OF NEUROSCIENCE, Vol: 32, Pages: 790-791, ISSN: 0020-7454
Tyrer P, 1986, Classification of anxiety disorders: A critique of DSM-III, Journal of Affective Disorders, Vol: 11, Pages: 99-104, ISSN: 0165-0327
CASEY PR, TYRER PJ, 1986, PERSONALITY, FUNCTIONING AND SYMPTOMATOLOGY, JOURNAL OF PSYCHIATRIC RESEARCH, Vol: 20, Pages: 363-374, ISSN: 0022-3956
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- Citations: 61
Tyrer P, 1985, NEUROSIS DIVISIBLE?, The Lancet, Vol: 325, Pages: 685-688, ISSN: 0140-6736
CASEY PR, TYRER PJ, PLATT S, 1985, THE RELATIONSHIP BETWEEN SOCIAL FUNCTIONING AND PSYCHIATRIC SYMPTOMATOLOGY IN PRIMARY CARE, SOCIAL PSYCHIATRY, Vol: 20, Pages: 5-9, ISSN: 0037-7813
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- Citations: 41
CICCHETTI DV, SHOWALTER D, TYRER PJ, 1985, THE EFFECT OF NUMBER OF RATING-SCALE CATEGORIES ON LEVELS OF INTERRATER RELIABILITY - A MONTE-CARLO INVESTIGATION, APPLIED PSYCHOLOGICAL MEASUREMENT, Vol: 9, Pages: 31-36, ISSN: 0146-6216
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- Citations: 147
Murphy SM, Owen RT, Tyrer PJ, 1984, Withdrawal symptoms after six weeks' treatment with diazepam., Lancet, Vol: 2, ISSN: 0140-6736
Tyrer P, Cicchetti DV, Casey PR, et al., 1984, Cross-national reliability study of a schedule for assessing personality disorders., J Nerv Ment Dis, Vol: 172, Pages: 718-721, ISSN: 0022-3018
The inter-rater reliability of a schedule used to assess personality disorders was examined. The Personality Assessment Schedule (PAS) involves an interview with both the patient and a close informant and the ratings for the informant are given most weight in the final scoring. Videotaped interviews with 23 psychiatric patients, most of whom had a clinical diagnosis of personality disorder, and a close informant were scored by seven raters, four in the United Kingdom and three in the United States. Overall inter-rater reliabilities (using the intraclass correlation coefficient, RI) were generally good to excellent for each of the 24 personality variables tested, ranging between .66 and .94 for informants and between .51 and .91 for subjects. Corresponding reliability coefficients for overall mean PAS scores were .82 and .75, respectively. Consistent with these findings, there was little bias between the scores of American and British raters, although there was some tendency for American raters to score higher for the trait of eccentricity and lower for the trait of conscientiousness than was true for British raters. There was less bias for informants' ratings than for those of subjects. In a second set of analyses, it was shown that inter-rater reliability levels (using the Kappa statistic) were also good to excellent (.6 to .8) for the categorical diagnosis of personality disorder. These results, taken together, demonstrate that abnormal personality can be reliably assessed by both British and American raters.
Tyrer P, Owen RT, Cicchetti DV, 1984, The brief scale for anxiety: a subdivision of the comprehensive psychopathological rating scale., Journal of Neurology, Neurosurgery & Psychiatry, Vol: 47, Pages: 970-975, ISSN: 0022-3050
Tyrer P, Seivewright N, Wollerton S, 1984, General Practice Psychiatric Clinics, British Journal of Psychiatry, Vol: 145, Pages: 15-19, ISSN: 0007-1250
<jats:title>Summary</jats:title><jats:p>The impact of devolving out-patient care to general practice (GP) psychiatric clinics over a two-year period is examined by comparing the frequency of contact with different psychiatric services in practices with and without psychiatric clinics. The clinics led to an increase in the number of outpatients seen, but to a fall in the number of new referrals. There was also a relative increase in the number of domiciliary visits and increase in acute day hospital referrals. The most important result was a 20 per cent fall in the number of admissions to the psychiatric hospital, which took place at a time when the national trend of falling admission rates was reversed. The findings suggest that psychiatric resources for in-patients can be deployed successfully in primary care without any increase in staffing.</jats:p>
Tyrer P, 1984, Psychiatric Clinics in General Practice, British Journal of Psychiatry, Vol: 145, Pages: 9-14, ISSN: 0007-1250
<jats:title>Summary</jats:title><jats:p>The patients seen at five psychiatric clinics in general practice (GP) serving an urban population of 78, 200 are described, and their attitudes to the clinic compared with those for conventional out-patient clinics. The GP psychiatric clinics were strongly preferred, mainly because of their ease of access and absence of stigma; 19 per cent of the patients seen would not have attended a hospital clinic. The patients seen encompassed the entire range of psychiatric disorder, but most were treated in the clinic or by other members of the primary care team. It is concluded that GP psychiatric clinics offer a way of achieving better community psychiatry without any need for increased resources.</jats:p>
Tyrer PJ, 1984, Benzodiazepines on trial., Br Med J (Clin Res Ed), Vol: 288, Pages: 1101-1102, ISSN: 0267-0623
Tyrer P, 1984, Clinical effects of abrupt withdrawal from tri-cyclic antidepressants and monoamine oxidase inhibitors after long-term treatment, Journal of Affective Disorders, Vol: 6, Pages: 1-7, ISSN: 0165-0327
Tyrer P, 1984, Classification of Anxiety, British Journal of Psychiatry, Vol: 144, Pages: 78-83, ISSN: 0007-1250
<jats:title>Summary</jats:title><jats:p>Current psychiatric classifications of anxiety are examined critically. In the European literature a specific cluster of symptoms is diagnostic of anxiety neurosis and their subsidiary classification is based on precipitating factors and duration of symptoms. In the American literature, exemplified by DSM-III, greater emphasis is placed on symptomatic classification and panic is given separate diagnostic status, both alone and in conjunction with agoraphobia. In both classifications generalized anxiety is at the bottom of a diagnostic hierarchy so that all other symptoms take precedence. It is argued that neither classification properly identifies a discrete syndrome of pathological anxiety that is recognizable in clinical practice.</jats:p>
SEIVEWRIGHT N, TYRER PJ, 1984, USE OF BETA-BLOCKING DRUGS IN WITHDRAWAL STATES, POSTGRADUATE MEDICAL JOURNAL, Vol: 60, Pages: 47-50, ISSN: 0032-5473
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- Citations: 5
CASEY PR, DILLON S, TYRER PJ, 1984, THE DIAGNOSTIC STATUS OF PATIENTS WITH CONSPICUOUS PSYCHIATRIC MORBIDITY IN PRIMARY CARE, PSYCHOLOGICAL MEDICINE, Vol: 14, Pages: 673-681, ISSN: 0033-2917
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- Citations: 47
Tyrer PJ, Seivewright N, 1984, Identification and management of benzodiazepine dependence., Postgrad Med J, Vol: 60 Suppl 2, Pages: 41-46, ISSN: 0032-5473
TYRER PJ, SEIVEWRIGHT N, 1984, IDENTIFICATION AND MANAGEMENT OF BENZODIAZEPINE DEPENDENCE, POSTGRADUATE MEDICAL JOURNAL, Vol: 60, Pages: 41-46, ISSN: 0032-5473
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- Citations: 47
Seivewright N, Tyrer PJ, 1984, Use of beta-blocking drugs in withdrawal states., Postgrad Med J, Vol: 60 Suppl 2, Pages: 47-50, ISSN: 0032-5473
MURPHY SM, OWEN RT, TYRER PJ, 1984, WITHDRAWAL SYMPTOMS AFTER 6 WEEKS TREATMENT WITH DIAZEPAM, LANCET, Vol: 2, Pages: 1389-1389, ISSN: 0140-6736
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- Citations: 78
Pullinger S, Tyrer P, 1983, Acute lithium-induced tremor., Br J Psychiatry, Vol: 143, Pages: 40-41, ISSN: 0007-1250
Tyrer P, Owen R, Dawling S, 1983, GRADUAL WITHDRAWAL OF DIAZEPAM AFTER LONG-TERM THERAPY, The Lancet, Vol: 321, Pages: 1402-1406, ISSN: 0140-6736
Tyrer P, Strauss J, Cicchetti D, 1983, Temporal reliability of personality in psychiatric patients, Psychological Medicine, Vol: 13, Pages: 393-398, ISSN: 0033-2917
<jats:title>SYNOPSIS</jats:title><jats:p>The Personality Assessment Schedule, an interview schedule specifically designed for assessing personality disorder, was administered twice to 28 psychiatric patients, with a mean interval of 2·9 years between each assessment. The first assessment was made by a psychiatrist and the second by a medical student who had no prior knowledge of the patients. The reliability of the 2 assessments was measured using 4 different techniques. Although the reliability of individual personality traits was inconsistent over time, the categorical diagnosis of personality disorder was good (K<jats:sub>ωw</jats:sub> = 0·64), giving some support to the validity of the schedule. Reasons for discordance in the assessments were examined and appeared to be due mainly to confusion between clinical symptoms and personality traits, retrospective errors in recording past personality in chronic patients, and special difficulties in determining the primary abnormality in severe personality disorder.</jats:p>
Tyrer P, Casey P, Gall J, 1983, the relationship between neurosis and personality disorder, British Journal of psychiatry
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