Imperial College London
Alternate

Emeritus ProfessorPeterTyrer

Faculty of Medicine, Department of Brain Sciences

Emeritus Professor in Community Psychiatry - Clinical
 
 
 
//

Contact

 

+44 (0)20 3313 4161p.tyrer

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Tyrer:2022:10.1017/S0033291721000878,
author = {Tyrer, P and Tyrer, H and Johnson, T and Yang, M},
doi = {10.1017/S0033291721000878},
journal = {Psychological Medicine},
pages = {3999--4008},
title = {Thirty year outcome of anxiety and depressive disorders and personality status: comprehensive evaluation of mixed symptoms and the general neurotic syndrome in the follow-up of a randomised controlled trial},
url = {http://dx.doi.org/10.1017/S0033291721000878},
volume = {52},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundCohort studies of the long-term outcome of anxiety, depression and personality status rarely join together.MethodsTwo hundred and ten patients recruited with anxiety and depression to a randomised controlled trial between 1983 and 1987 (Nottingham Study of Neurotic Disorder) were followed up over 30 years. At trial entry personality status was assessed, together with the general neurotic syndrome, a combined diagnosis of mixed anxiety–depression (cothymia) linked to neurotic personality traits. Personality assessment used a procedure allowing conversion of data to the ICD-11 severity classification of personality disorder. After the original trial, seven further assessments were made. Observer and self-ratings of psychopathology and global outcome were also made. The primary outcome at 30 years was the proportion of those with no Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnosis.Data were analysed using multilevel repeated measures models that adjusted for age and gender. Missing data were assumed to be missing at random, and the models allowed all subjects to be included in the analysis with missing data automatically handled in the model estimation.ResultsAt 30 years, 69% of those with a baseline diagnosis of panic disorder had no DSM diagnosis compared to 37–47% of those with generalised anxiety disorder, dysthymia or mixed symptoms (cothymia) (p = 0.027). Apart from those with no personality dysfunction at entry all patients had worse outcomes after 30 years with regard to total psychopathology, anxiety and depression, social function and global outcome.ConclusionsThe long-term outcome of disorders formerly called ‘neurotic’ is poor with the exception of panic disorder. Personality dysfunction accentuates poor recovery.
AU  - Tyrer,P
AU  - Tyrer,H
AU  - Johnson,T
AU  - Yang,M
DO  - 10.1017/S0033291721000878
EP  - 4008
PY  - 2022///
SN  - 0033-2917
SP  - 3999
TI  - Thirty year outcome of anxiety and depressive disorders and personality status: comprehensive evaluation of mixed symptoms and the general neurotic syndrome in the follow-up of a randomised controlled trial
T2  - Psychological Medicine
UR  - http://dx.doi.org/10.1017/S0033291721000878
UR  - http://hdl.handle.net/10044/1/88494
VL  - 52
ER  -
Download