Dr Petr Vikhorev is a research fellow at the National Heart and Lung Institute, Imperial College London. His research interests focus on the mechanisms and regulation of muscle contraction. He is the principal investigator of the BHF research project grant “Effect of mutations associated with dilated and hypertrophic cardiomyopathies on myofibril mechanical properties and contractility”.
He has a broad range of expertise including single myofibril force measurements, polarised fluorescence fluorometry, in vitro motility assay technique, analytical and preparative biochemistry, computer control of instrumentation and writing LabVIEW software. He built the apparatus and wrote the software for the measurement and analysis of myofibril contractile dynamics and is currently using this technique to the study of cardiomyopathy.
He was educated in Saint-Petersburg State University, Faculty of Biology and Soil Sciences and Faculty of Applied Mathematics and Control Processes, where he obtained his BSc in Biology (1997) and MSc in Biophysics (1999). In 2003 he received his PhD in Histology, Cytology and Cellular Biology from the Institute of Cytology of the Russian Academy of Sciences.
He worked at the Nencki Institute of Experimental Biology of the Polish Academy of Sciences (1999-2001, visiting researcher), at the University of York (2004-2005, postdoctoral researcher), at the Linnaeus University (2006-2009, postdoctoral researcher), and at the Imperial College London (2009-2017, research associate).
et al., 2018, Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes, Scientific Reports, Vol:8, ISSN:2045-2322
Vikhorev P, Vikhoreva N, 2018, Cardiomyopathies and related changes in contractility of human heart muscle, International Journal of Molecular Sciences, Vol:19, ISSN:1422-0067
et al., Differential Regulation of Post-translational Modifications in Human Hypertrophic Cardiomyopathy Revealed by Top-down Proteomics, US HUPO 2020 - 16th Annual conference
et al., Contractility of myofibrils from patients with dilated cardiomyopathy associated mutations, Alpbach Meeting on Muscle Molecular Motors
et al., 2018, Contractility of ventricular myofibrils from patients with dilated cardiomyopathy associated mutations, 47th European Muscle Conference, Springer Science and Business Media LLC, Pages:65-115, ISSN:0142-4319