Imperial College London

Professor Peter Vincent

Faculty of EngineeringDepartment of Aeronautics

Professor of Computational Fluid Dynamics



+44 (0)20 7594 1975p.vincent




211City and Guilds BuildingSouth Kensington Campus






BibTex format

author = {Grechy, L and Iori, F and Corbett, R and Shurey, S and Gedroyc, W and Duncan, N and Caro, C and Vincent, PE},
doi = {10.1063/1.5004190},
journal = {Physics of Fluids},
title = {Suppressing Unsteady Flow in Arterio-Venous Fistulae},
url = {},
volume = {29},
year = {2017}

RIS format (EndNote, RefMan)

AB - Arterio-Venous Fistulae (AVF) are regarded as the “gold standard” method of vascular access forpatients with end-stage renal disease who require haemodialysis. However, a large proportion ofAVF do not mature, and hence fail, as a result of various pathologies such as Intimal Hyperplasia(IH). Unphysiological flow patterns, including high-frequency flow unsteadiness, associated with theunnatural and often complex geometries of AVF are believed to be implicated in the developmentof IH. In the present study, we employ a Mesh Adaptive Direct Search optimisation framework,computational fluid dynamics simulations, and a new cost function to design a novel non-planar AVFconfiguration that can suppress high-frequency unsteady flow. A prototype device for holding an AVFin the optimal configuration is then fabricated, and proof-of-concept is demonstrated in a porcinemodel. Results constitute the first use of numerical optimisation to design a device for suppressingpotentially pathological high-frequency flow unsteadiness in AVF.
AU - Grechy,L
AU - Iori,F
AU - Corbett,R
AU - Shurey,S
AU - Gedroyc,W
AU - Duncan,N
AU - Caro,C
AU - Vincent,PE
DO - 10.1063/1.5004190
PY - 2017///
SN - 1070-6631
TI - Suppressing Unsteady Flow in Arterio-Venous Fistulae
T2 - Physics of Fluids
UR -
UR -
VL - 29
ER -