ProfessorPaoloVineis

Vineis P, Husgafvel-Pursiainen K, 2005, Air pollution and cancer: biomarker studies in human populations, CARCINOGENESIS, Vol: 26, Pages: 1846-1855, ISSN: 0143-3334

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• Citations: 213

Rohrmann S, Linseisen J, Vineis P, Riboli Eet al., 2005, Ethanol intake and lung cancer risk in the European prospective investigation into cancer and nutrition (EPIC)., 4th Annual Conference on Frontiers in Cancer Prevention Research, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 2726S-2726S, ISSN: 1055-9965

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Schulz M, Lahmann PH, Boeing H, Hoffmann K, Allen N, Key TJA, Bingham S, Wirfält E, Berglund G, Lundin E, Hallmans G, Lukanova A, Garcia CM, González CA, Tormo MJ, Quirós JR, Ardanaz E, Larrañaga N, Lund E, Gram IT, Skeie G, Peeters PHM, van Gils CH, Bueno-de-Mesquita HB, Büchner FL, Pasanisi P, Galasso R, Palli D, Tumino R, Vineis P, Trichopoulou A, Kalapothaki V, Trichopoulos D, Chang-Claude J, Linseisen J, Boutron-Ruault MC, Touillaud M, Clavel-Chapelon F, Olsen A, Tjonneland A, Overvad K, Tetsche M, Jenab M, Norat T, Kaaks R, Riboli Eet al., 2005, Fruit and vegetable consumption and risk of epithelial ovarian cancer:: The European prospective investigation into cancer and nutrition, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 2531-2535, ISSN: 1055-9965

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• Citations: 48

Matullo G, Guarrera S, Sacerdote C, Polidoro S, Davico L, Gamberini S, Karagas M, Casetta G, Rolle L, Piazza A, Vineis Pet al., 2005, Polymorphisms/haplotypes in DNA repair genes and smoking: A bladder cancer case-control study, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 2569-2578, ISSN: 1055-9965

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• Citations: 111

Canzian F, McKay JD, Cleveland RJ, Dossus L, Biessy C, Boillot C, Rinaldi S, Llewellyn M, Chajès V, Clavel-Chapelon F, Téhard B, Chang-Claude J, Linseisen J, Lahmann PH, Pischon T, Trichopoulos D, Trichopoulou A, Zilis D, Palli D, Tumino R, Vineis P, Berrino F, Bueno-de-Mesquita HB, van Gils CH, Peeters PHM, Pera G, Barricarte A, Chirlaque MD, Quirós JR, Larrañaga N, Martínez-García C, Allen NE, Key TJ, Bingham SA, Khaw KT, Slimani N, Norat T, Riboli E, Kaaks Ret al., 2005, Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk:: Results from the European Prospective Investigation into Cancer and Nutrition Study, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 2316-2325, ISSN: 1055-9965

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• Citations: 33

Vineis P, 2005, Scientific basis for the Precautionary Principle., Toxicol Appl Pharmacol, Vol: 207, Pages: 658-662

The Precautionary Principle is based on two general criteria: (a) appropriate public action should be taken in response to limited, but plausible and credible, evidence of likely and substantial harm; (b) the burden of proof is shifted from demonstrating the presence of risk to demonstrating the absence of risk. Not much has been written about the scientific basis of the precautionary principle, apart from the uncertainty that characterizes epidemiologic research on chronic disease, and the use of surrogate evidence when human evidence cannot be provided. It is proposed in this paper that a new scientific paradigm, based on the theory of evolution, is emerging; this might offer stronger support to the need for precaution in the regulation of environmental risks. Environmental hazards do not consist only in direct attacks to the integrity of DNA or other macromolecules. They can consist in changes that take place already in utero, and that condition disease risks many years later. Also, environmental exposures can act as "stressors", inducing hypermutability (the mutator phenotype) as an adaptive response. Finally, environmental changes should be evaluated against a background of a not-so-easily modifiable genetic make-up, inherited from a period in which humans were mainly hunters-gatherers and had dietary habits very different from the current ones.

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Peluso M, Munnia A, Hoek G, Krzyzanowski M, Veglia F, Airoldi L, Autrup H, Dunning A, Garte S, Hainaut P, Malaveille C, Gormally E, Matullo G, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulou A, Trichopoulos D, Kaladidi A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Kumle M, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros JR, Berglund G, Janzon L, Jarvholm B, Day NE, Key TJ, Saracci R, Kaaks R, Riboli E, Vineis Pet al., 2005, DNA adducts and lung cancer risk: A prospective study, CANCER RESEARCH, Vol: 65, Pages: 8042-8048, ISSN: 0008-5472

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• Citations: 82

Vineis P, 2005, Single and multiple genes as determinants of individual susceptibility, TOXICOLOGY LETTERS, Vol: 158, Pages: S18-S18, ISSN: 0378-4274

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Vineis P, Ahsan H, Parker M, 2005, Genetic screening and occupational and environmental exposures, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 62, Pages: 657-662, ISSN: 1351-0711

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• Citations: 14

Airoldi L, Vineis P, Colombi A, Olgiati L, Dell'Osta C, Fanelli R, Manzi L, Veglia F, Autrup H, Dunning A, Garte S, Hainaut P, Hoek G, Krzyzanowski M, Malaveille C, Matullo G, Overvad K, Tjonneland A, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulou A, Palli D, Peluso M, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Agudo A, Martinez C, Dorronsoro M, Barricarte A, Chirlaque MD, Quiros JR, Berglund G, Järvholm B, Hallmans G, Day NE, Allen N, Saracci R, Kaaks R, Riboli Eet al., 2005, 4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 2118-2124, ISSN: 1055-9965

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• Citations: 28

Ioannidis JPA, Bernstein J, Boffetta P, Danesh J, Dolan S, Hartge P, Hunter D, Inskip P, Jarvelin MR, Little J, Maraganore DM, Bishop JAN, O'Brien TR, Petersen G, Riboli E, Seminara D, Taioli E, Uitterlinden AG, Vineis P, Winn DM, Salanti G, Higgins JPT, Khoury MJet al., 2005, A network of investigator networks in human genome epidemiology, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 162, Pages: 302-304, ISSN: 0002-9262

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• Citations: 87

Rundle AG, Vineis P, Ahsan H, 2005, Design options for molecular epidemiology research within cohort studies, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 1899-1907, ISSN: 1055-9965

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• Citations: 82

Peluso M, Hainaut P, Airoldi L, Autrup H, Dunning A, Garte S, Gormally E, Malaveille C, Matullo G, Munnia A, Riboli E, Vineis Pet al., 2005, Methodology of laboratory measurements in prospective studies on gene-environment interactions: The experience of GenAir, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 574, Pages: 92-104, ISSN: 0027-5107

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• Citations: 40

Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, Overvad K, Olsen A, Tjonneland A, Clavel F, Boutron-Ruault MC, Kesse E, Boeing H, Bergmann MM, Nieters A, Linseisen J, Trichopoulou A, Trichopoulos D, Tountas Y, Berrino F, Palli D, Panico S, Tumino R, Vineis P, Bueno-De-Mesquita HB, Peeters PHM, Engeset D, Lund E, Skeie G, Ardanaz E, González C, Navarro C, Quirós JR, Sanchez MJ, Berglund G, Mattisson I, Hallmans G, Palmqvist R, Day NE, Khaw KT, Key TJ, San Joaquin M, Hémon B, Saracci R, Kaaks R, Riboli Eet al., 2005, Meat, fish, and colorectal cancer risk:: The European prospective investigation into cancer and nutrition, JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 97, Pages: 906-916, ISSN: 0027-8874

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• Citations: 613

Bingham SA, Norat T, Moskal A, Ferrari P, Slimani N, Clavel-Chapelon F, Kesse E, Nieters A, Boeing H, Tjonneland A, Overvad K, Martinez C, Dorronsoro M, González CA, Ardanaz E, Navarro C, Quirós JR, Key TJ, Day NE, Trichopoulou A, Naska A, Krogh V, Tumino R, Palli D, Panico S, Vineis P, Bueno-de-Mesquita HB, Ocké MC, Peeters PHM, Berglund G, Hallmans G, Lund E, Skeie G, Kaaks R, Riboli Eet al., 2005, Is the association with fiber from foods in colorectal cancer confounded by folate intake?, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 1552-1556, ISSN: 1055-9965

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• Citations: 94

Bezemer ID, Rinaldi S, Dossus L, van Gils CH, Peeters PHM, Noord PAH, Bueno-de-Mesquita HB, Johnsen SP, Overvad K, Olsen A, Tjonneland A, Boeing H, Lahmann PH, Linseisen J, Nagel G, Allen N, Roddam A, Bingham S, Khaw KT, Kesse E, Téhard B, Clavel-Chapelon F, Agudo A, Ardanaz E, Quiros JR, Amiano P, Martínez-Garcia C, Tormo MJ, Pala V, Panico S, Vineis P, Palli D, Tumino R, Trichopoulou A, Baibas N, Zilis D, Hémon B, Norat T, Riboli E, Kaaks Ret al., 2005, C-peptide, IGF-I, sex-steroid hormones and adiposity:: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC), CANCER CAUSES & CONTROL, Vol: 16, Pages: 561-572, ISSN: 0957-5243

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• Citations: 83

Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, Secreto G, Amiano P, Bingham S, Boeing H, de Mesquita HBB, Chang-Claude J, Clavel-Chapelon FO, Fournier AS, van Gils CH, Gonzalez CA, Gurrea AB, Critselis E, Khaw KT, Krogh V, Lahmann PH, Nagel G, Olsen A, Onland-Moret NC, Overvad K, Palli D, Panico S, Peeters P, Quirós JR, Roddam A, Thiebaut A, Tjonneland A, Chirlaque MD, Trichopoulou A, Trichopoulos D, Tumino R, Vineis P, Norat T, Ferrari P, Slimani N, Riboli Eet al., 2005, Serum sex steroids in premenopausal women and breast cancer risk within the European prospective investigation into cancer and nutrition (EPIC), JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 97, Pages: 755-765, ISSN: 0027-8874

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• Citations: 334

Trichopoulou A, Orfanos P, Norat T, Bueno-de-Mesquita B, Ocké MC, Peeters PHM, van der Schouw YT, Boeing H, Hoffmann K, Boffetta P, Nagel G, Masala G, Krogh V, Panico S, Tumino R, Vineis P, Bamia C, Naska A, Benetou V, Ferrari P, Slimani N, Pera G, Martinez-Garcia C, Navarro C, Rodriguez-Barranco M, Dorronsoro M, Spencer EA, Key TJ, Bingham S, Khaw K-T, Kesse E, Clavel-Chapelon F, Boutron-Ruault M-C, Berglund G, Wirfalt E, Hallmans G, Johansson I, Tjonneland A, Olsen A, Overvad K, Hundborg HH, Riboli E, Trichopoulos Det al., 2005, Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study., BMJ, Vol: 330

OBJECTIVE: To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. DESIGN: Multicentre, prospective cohort study. SETTING: Nine European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, United Kingdom). PARTICIPANTS: 74,607 men and women, aged 60 or more, without coronary heart disease, stroke, or cancer at enrolment and with complete information about dietary intake and potentially confounding variables. MAIN OUTCOME MEASURES: Extent of adherence to a modified Mediterranean diet using a scoring system on a 10 point scale, and death from any cause by time of occurrence, modelled through Cox regression. RESULTS: An increase in the modified Mediterranean diet score was associated with lower overall mortality, a two unit increment corresponding to a statistically significant reduction of 8% (95% confidence interval 3% to 12%). No statistically significant evidence of heterogeneity was found among countries in the association of the score with overall mortality even though the association was stronger in Greece and Spain. When dietary exposures were calibrated across countries, the reduction in mortality was 7% (1% to 12%). CONCLUSION: The Mediterranean diet, modified so as to apply across Europe, was associated with increased survival among older people.

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Matullo G, Berwick M, Vineis P, 2005, Gene-environment interactions: How many false positives?, JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 97, Pages: 550-551, ISSN: 0027-8874

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• Citations: 16

Morton LM, Hartge P, Holford TR, Holly EA, Chiu BCH, Vineis P, Stagnaro E, Willett EV, Franceschi S, La Vecchia C, Hughes AM, Cozen W, Davis S, Severson RK, Bernstein L, Mayne ST, Dee FR, Cerhan JR, Zheng TZet al., 2005, Cigarette smoking and risk of non-Hodgkin lymphoma: A pooled analysis from the international lymphoma epidemiology consortium (InterLymph), CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 925-933, ISSN: 1055-9965

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• Citations: 131

Solerio E, Tappero G, Iannace L, Matullo G, Ayoubi M, Parziale A, Cicilano M, Sansoè G, Framarin L, Vineis P, Rosina Fet al., 2005, CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer., Dig Liver Dis, Vol: 37, Pages: 170-175, ISSN: 1590-8658

BACKGROUND AND AIMS: Colorectal cancer is a major health problem. Colonoscopic colorectal cancer screening is cumbersome and expensive. Identification of genetic risk of colorectal cancer may help to select the subjects who could benefit from colonoscopy. The immune system plays a fundamental role in the human-environment interaction, and the carcinogenic effects of many environmental factors are mediated by the chronic activation of the immune system in a genetic-controlled fashion. Cytotoxic T lymphocyte associated antigen 4 (CTLA4) plays an inhibitory role in regulating lymphocyte functions. The loss of CTLA4 function is responsible for loss of mucosal lymphocyte tolerance. The G allele at position +49 of exon 1 of the CTLA4 gene affects the CTLA4 function. We evaluated in an association study the role of CTLA4 A+49G polymorphism as a risk factor for colorectal neoplasm. PATIENTS AND METHODS: Five hundred and fifty-six patients (male 295; female 261) who underwent colonoscopy at our Centre were enrolled in the study and divided into three groups: Colorectal cancer (132 patients, M/F 68/64, mean age 66+/-11 years); Colorectal adenoma (186 patients, M/F 110/76, mean age 65+/-11 years); Healthy controls (238 patients, M/F 117/121, mean age 63+/-10 years). DNA was extracted from peripheral blood, CTLA4 gene was amplified by using specific primers, and A+49G polymorphism was analysed by restriction enzyme digestion. RESULTS: No statistically significant differences in the genotype distribution among Control and Adenoma groups (p=0.93), Control and Carcinoma groups (p=0.52), and Adenoma and Carcinoma groups (p=0.53) were observed. CONCLUSION: There is no significant correlation between CTLA4 A+49G polymorphism and the risk of colorectal neoplasm among Italian Caucasians.

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Vineis P, 2005, Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study, BRITISH MEDICAL JOURNAL, Vol: 330, Pages: 277-280A, ISSN: 0959-535X

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• Citations: 189

Berwick M, Vineis P, 2005, Measuring DNA repair capacity: Small steps, JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 97, Pages: 84-85, ISSN: 0027-8874

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• Citations: 22

van Gils CH, Peeters PHT, Bueno-De-Mesquita HB, Boshuizen HC, Lahmann PH, Clavel-Chapelon F, Thiébaut A, Kesse E, Sieri S, Palli D, Tumino R, Panico S, Vineis P, Gonzalez CA, Ardanaz E, Sánchez MJ, Amiano P, Navarro C, Quirós JR, Key TJ, Allen N, Khaw KT, Bingham SA, Psaltopoulou T, Koliva M, Trichopoulou A, Nagel G, Linseisen J, Boeing H, Berglund G, Wirfält E, Hallmans G, Lenner P, Overvad K, Tjonneland A, Olsen A, Lund E, Engeset D, Alsaker E, Norat TA, Kaaks R, Slimani N, Riboli Eet al., 2005, Consumption of vegetables and fruits and risk of breast cancer, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 293, Pages: 183-193, ISSN: 0098-7484

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• Citations: 189

Vineis P, 2005, Bladder cancers, Cancer Risk Assessment, Pages: 717-733, ISBN: 9780824729844

In this chapter we review the most relevant data that permit the risk assessment of bladder cancer, based on the measurement of biomarkers. We consider separately biomarkers relevant to the etiology, and biomarkers relevant to the clinical assessment of such cancers. Many biomarkers have been suggested for use, particularly for clinical purposes, and our review cannot be exhaustive. Therefore, we have selected p53 as a particularly representative clinical marker.

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P Vineis, G Matullo, M Berwick, 2005, Molecular epidemiology, Handbook of epidemiology, Editors: Ahrens, Pigeot, Berlin, Publisher: Sringer

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Berwick M, Matullo G, Song YS, Guarrera S, Dominguez G, Orlow I, Walker M, Vineis Pet al., 2004, Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma, JOURNAL OF CLINICAL ONCOLOGY, Vol: 22, Pages: 3997-4001, ISSN: 0732-183X

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• Citations: 26

Vineis P, 2004, A self-fulfilling prophecy: are we underestimating the role of the environment in gene-environment interaction research?, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 33, Pages: 945-946, ISSN: 0300-5771

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• Citations: 52

Vineis P, Forastiere F, Hoek G, Lipsett Met al., 2004, Outdoor air pollution and lung cancer: Recent epidemiologic evidence, INTERNATIONAL JOURNAL OF CANCER, Vol: 111, Pages: 647-652, ISSN: 0020-7136

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• Citations: 105

Gormally E, Hainaut P, Caboux E, Airoldi L, Autrup H, Malaveille C, Dunning A, Garte S, Matullo G, Overvad K, Tjonneland A, Clavel-Chapelon F, Boffetta P, Boeing H, Trichopoulou A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Tormo MJ, Quiros JR, Berglund G, Hallmans G, Day NE, Key TJ, Veglia F, Peluso M, Norat T, Saracci R, Kaaks R, Riboli E, Vineis Pet al., 2004, Amount of DNA in plasma and cancer risk: A prospective study, INTERNATIONAL JOURNAL OF CANCER, Vol: 111, Pages: 746-749, ISSN: 0020-7136

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• Citations: 84