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@article{Robinson:2021:ije/dyaa188,
author = {Robinson, O and Carter, AR and Aola-Korpela, M and Casas, JP and Chaturvedi, N and Engmann, J and Howe, LD and Hughes, A and Jarvelin, MJ and Kahonen, M and Karhunen, V and Kuh, D and Shah, T and Ben-Shlomo, Y and Sofat, R and Lau, CE and Lehtimaki, T and Menon, U and Raitakari, O and Ryan, A and Providencia, R and Smith, S and Taylor, J and Tillin, T and Viikari, J and Wong, A and Hingorani, AD and Kivimaki, M and Vineis, P},
doi = {ije/dyaa188},
journal = {International Journal of Epidemiology},
pages = {768--782},
title = {Metabolic profiles of socioeconomic position: a multi-cohort analysis},
url = {http://dx.doi.org/10.1093/ije/dyaa188},
volume = {50},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundLow socioeconomic position (SEP) is a risk factor for multiple health outcomes, but its molecular imprints in the body remain unclear. MethodsWe examined SEP as a determinant of serum nuclear magnetic resonance metabolic profiles, in approximately 30,000 adults and 4,000 children across ten UK and Finnish cohort studies. ResultsIn risk factor-adjusted analysis of 233 metabolic measures, low educational attainment was associated with 37 measures including higher levels of triglycerides in small high-density lipoproteins (HDL) and lower levels of docosahexaenoic acid (DHA), omega-3 fatty acids, apolipoprotein A1, large and very large HDL particles (including levels of their respective lipid constituents), and cholesterol measures across different density lipoproteins. Among adults whose father worked in manual occupations, associations with apolipoprotein A1, large and very large HDL particles and HDL-2 cholesterol remained after adjustment for SEP in later life. Among manual workers, levels of glutamine were higher compared to non-manual workers. All three indicators of low SEP were associated with lower DHA, omega-3 fatty acids and HDL diameter. At all ages, children of manual workers had lower levels of DHA as a proportion of total fatty acids.ConclusionsOur work indicates that social and economic factors have a measurable impact on human physiology. Lower SEP was independently associated with a generally unfavorable metabolic profile, consistent across ages and cohorts. The metabolites we found associated with SEP, including DHA, are known to predict cardiovascular disease and cognitive decline in later life and may contribute to health inequalities.
AU  - Robinson,O
AU  - Carter,AR
AU  - Aola-Korpela,M
AU  - Casas,JP
AU  - Chaturvedi,N
AU  - Engmann,J
AU  - Howe,LD
AU  - Hughes,A
AU  - Jarvelin,MJ
AU  - Kahonen,M
AU  - Karhunen,V
AU  - Kuh,D
AU  - Shah,T
AU  - Ben-Shlomo,Y
AU  - Sofat,R
AU  - Lau,CE
AU  - Lehtimaki,T
AU  - Menon,U
AU  - Raitakari,O
AU  - Ryan,A
AU  - Providencia,R
AU  - Smith,S
AU  - Taylor,J
AU  - Tillin,T
AU  - Viikari,J
AU  - Wong,A
AU  - Hingorani,AD
AU  - Kivimaki,M
AU  - Vineis,P
DO  - ije/dyaa188
EP  - 782
PY  - 2021///
SN  - 0300-5771
SP  - 768
TI  - Metabolic profiles of socioeconomic position: a multi-cohort analysis
T2  - International Journal of Epidemiology
UR  - http://dx.doi.org/10.1093/ije/dyaa188
UR  - https://academic.oup.com/ije/article/50/3/768/5998283
UR  - http://hdl.handle.net/10044/1/82322
VL  - 50
ER  -

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