Imperial College London
Alternate

ProfessorPaoloVineis

Faculty of Medicine, School of Public Health

Chair in Environmental Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
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Location

 

511Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dagnino:2021:10.1158/0008-5472.CAN-20-3454,
author = {Dagnino, S and Bodinier, B and Guida, F and Smith-Byrne, K and Petrovic, D and Whitaker, M and Haugdahl, T and Agnoli, C and Palli, D and Sacerdote, C and Panico, S and Tumino, R and Schulze, M and Johansson, M and Keski-Rahkonen, P and Scalbert, A and Vineis, P and Mattias, J and Sandanger, T and Vermeulen, R and Chadeau, M},
doi = {10.1158/0008-5472.CAN-20-3454},
journal = {Cancer Research},
title = {Prospective identification of elevated circulating CDCP1 in patients years before onset of lung cancer},
url = {http://dx.doi.org/10.1158/0008-5472.CAN-20-3454},
volume = {81},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Increasing evidence points to a role for inflammation in lung carcinogenesis. A small number of circulating inflammatory proteins have been identified as showing elevated levels prior to lung cancer diagnosis, indicating the potential for prospective circulating protein concentration as a marker of early carcinogenesis. In order to identify novel markers of lung cancer risk, we measured a panel of 92 circulating inflammatory proteins in 648 pre-diagnostic blood samples from two prospective cohorts in Italy and Norway (women only). To preserve the comparability of results and protect against confounding factors, the main statistical analyses were conducted in women from both studies, with replication sought in men (Italian participants). Univariate and penalized regression models revealed for the first time higher blood levels of CDCP1 protein in cases that went on to develop lung cancer compared to controls, irrespective of time to diagnosis, smoking habits, and gender. This association was validated in an additional 450 samples. Associations were stronger for future cases of adenocarcinoma where CDCP1 showed better explanatory performance. Integrative analyses combining gene expression and protein levels CDCP1 measured in the same individuals suggested a link between CDCP1 and the expression of transcripts of LRRN3 and SEM1. Enrichment analyses indicated a potential role for CDCP1 in pathways related to cell adhesion and mobility, such as the WNT/β-catenin pathway. Overall, this study identifies lung cancer-related dysregulation of CDCP1 expression years before diagnosis.
AU  - Dagnino,S
AU  - Bodinier,B
AU  - Guida,F
AU  - Smith-Byrne,K
AU  - Petrovic,D
AU  - Whitaker,M
AU  - Haugdahl,T
AU  - Agnoli,C
AU  - Palli,D
AU  - Sacerdote,C
AU  - Panico,S
AU  - Tumino,R
AU  - Schulze,M
AU  - Johansson,M
AU  - Keski-Rahkonen,P
AU  - Scalbert,A
AU  - Vineis,P
AU  - Mattias,J
AU  - Sandanger,T
AU  - Vermeulen,R
AU  - Chadeau,M
DO  - 10.1158/0008-5472.CAN-20-3454
PY  - 2021///
SN  - 0008-5472
TI  - Prospective identification of elevated circulating CDCP1 in patients years before onset of lung cancer
T2  - Cancer Research
UR  - http://dx.doi.org/10.1158/0008-5472.CAN-20-3454
UR  - https://cancerres.aacrjournals.org/content/81/13/3738
UR  - http://hdl.handle.net/10044/1/85881
VL  - 81
ER  -
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