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@article{Dugue:2022:10.1186/s13058-022-01554-8,
author = {Dugue, P-A and Bodelon, C and Chung, FF and Brewer, HR and Ambatipudi, S and Sampson, JN and Cuenin, C and Chajes, V and Romieu, I and Fiorito, G and Sacerdote, C and Krogh, V and Panico, S and Tumino, R and Vineis, P and Polidoro, S and Baglietto, L and English, D and Severi, G and Giles, GG and Milne, RL and Herceg, Z and Garcia-Closas, M and Flanagan, JM and Southey, MC},
doi = {10.1186/s13058-022-01554-8},
journal = {Breast Cancer Research},
pages = {1--9},
title = {Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies},
url = {http://dx.doi.org/10.1186/s13058-022-01554-8},
volume = {24},
year = {2022}
}

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TY  - JOUR
AB  - BackgroundDNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in the prediction of cancer risk. A substantial body of research has shown associations between epigenetic aging and risk of disease, including cancer. Here we aimed to study epigenetic measures of aging and lifestyle-related factors in association with risk of breast cancer.MethodsUsing data from four prospective case–control studies nested in three cohorts of European ancestry participants, including a total of 1,655 breast cancer cases, we calculated three methylation-based measures of lifestyle factors (body mass index [BMI], tobacco smoking and alcohol consumption) and seven measures of epigenetic aging (Horvath-based, Hannum-based, PhenoAge and GrimAge). All measures were regression-adjusted for their respective risk factors and expressed per standard deviation (SD). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional or unconditional logistic regression and pooled using fixed-effects meta-analysis. Subgroup analyses were conducted by age at blood draw, time from blood sample to diagnosis, oestrogen receptor-positivity status and tumour stage.ResultsNone of the measures of epigenetic aging were associated with risk of breast cancer in the pooled analysis: Horvath ‘age acceleration’ (AA): OR per SD = 1.02, 95%CI: 0.95–1.10; AA-Hannum: OR = 1.03, 95%CI:0.95–1.12; PhenoAge: OR = 1.01, 95%CI: 0.94–1.09 and GrimAge: OR = 1.03, 95%CI: 0.94–1.12, in models adjusting for white blood cell proportions, body mass index, smoking and alcohol consumption. The BMI-adjusted predictor of BMI was associated with breast cancer risk, OR per SD = 1.09, 95%CI: 1.01–1.17. The results for the alcohol and smoking methylation-based predictors were consistent with a null association. Risk did no
AU  - Dugue,P-A
AU  - Bodelon,C
AU  - Chung,FF
AU  - Brewer,HR
AU  - Ambatipudi,S
AU  - Sampson,JN
AU  - Cuenin,C
AU  - Chajes,V
AU  - Romieu,I
AU  - Fiorito,G
AU  - Sacerdote,C
AU  - Krogh,V
AU  - Panico,S
AU  - Tumino,R
AU  - Vineis,P
AU  - Polidoro,S
AU  - Baglietto,L
AU  - English,D
AU  - Severi,G
AU  - Giles,GG
AU  - Milne,RL
AU  - Herceg,Z
AU  - Garcia-Closas,M
AU  - Flanagan,JM
AU  - Southey,MC
DO  - 10.1186/s13058-022-01554-8
EP  - 9
PY  - 2022///
SN  - 1465-542X
SP  - 1
TI  - Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies
T2  - Breast Cancer Research
UR  - http://dx.doi.org/10.1186/s13058-022-01554-8
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000850566200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-022-01554-8
UR  - http://hdl.handle.net/10044/1/101059
VL  - 24
ER  -

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