Imperial College London
Alternate

ProfessorPaoloVineis

Faculty of Medicine, School of Public Health

Chair in Environmental Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
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Location

 

511Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Handakas:2022:10.1016/j.clnu.2022.09.002,
author = {Handakas, E and Chang, K and Khandpur, N and Vamos, EP and Millett, C and Sassi, F and Vineis, P and Robinson, O},
doi = {10.1016/j.clnu.2022.09.002},
journal = {Clinical Nutrition},
pages = {2537--2548},
title = {Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children},
url = {http://dx.doi.org/10.1016/j.clnu.2022.09.002},
volume = {41},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & aimsHigher consumption of ultra-processed foods (UPF) has been associated with childhood obesity, but underlying mechanisms remain unclear. We investigated plasma nuclear magnetic resonance metabolic profiles of higher UPF consumption and their role in obesity risk in the British ALSPAC cohort.MethodsWe performed cross-sectional and prospective metabolome wide association analyses of UPF, calculated from food diaries using the NOVA classification. In cross-sectional analysis, we tested the association between UPF consumption and metabolic profile at 7 years (N = 4528), and in the prospective analysis we tested the association between UPF consumption at 13 years and metabolic profile at 17 years (N = 3086). Effects of UPF-associated metabolites at 7 years on subsequent fat mass accumulation were assessed using growth curve models.ResultsAt 7 years, UPF was associated with 115 metabolic traits including lower levels of branched-chain and aromatic amino acids and higher levels of citrate, glutamine, and monounsaturated fatty acids, which were also associated with greater fat mass accumulation. Reported intake of nutrients mediated associations with most metabolites, except for citrate.ConclusionsUPF consumption among British children is associated with perturbation of multiple metabolic traits, many of which contribute to child obesity risk.
AU  - Handakas,E
AU  - Chang,K
AU  - Khandpur,N
AU  - Vamos,EP
AU  - Millett,C
AU  - Sassi,F
AU  - Vineis,P
AU  - Robinson,O
DO  - 10.1016/j.clnu.2022.09.002
EP  - 2548
PY  - 2022///
SN  - 0261-5614
SP  - 2537
TI  - Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
T2  - Clinical Nutrition
UR  - http://dx.doi.org/10.1016/j.clnu.2022.09.002
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000884108000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S0261561422003272?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101732
VL  - 41
ER  -
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