Imperial College London
Alternate

ProfessorPaoloVineis

Faculty of Medicine, School of Public Health

Chair in Environmental Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
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Location

 

511Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mantovani:2022:10.1038/s41418-022-01052-6,
author = {Mantovani, A and Morrone, MC and Patrono, C and Santoro, MG and Schiaffino, S and Remuzzi, G and Bussolati, G and Covid-19, Commission of the Accademia Nazionale dei Lincei},
doi = {10.1038/s41418-022-01052-6},
journal = {Cell Death Differ},
pages = {1891--1900},
title = {Long Covid: where we stand and challenges ahead.},
url = {http://dx.doi.org/10.1038/s41418-022-01052-6},
volume = {29},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially as Long Covid, has been defined as a constellation of signs and symptoms which persist for weeks or months after the initial SARS-CoV-2 infection. PASC affects a wide range of diverse organs and systems, with manifestations involving lungs, brain, the cardiovascular system and other organs such as kidney and the neuromuscular system. The pathogenesis of PASC is complex and multifactorial. Evidence suggests that seeding and persistence of SARS-CoV-2 in different organs, reactivation, and response to unrelated viruses such as EBV, autoimmunity, and uncontrolled inflammation are major drivers of PASC. The relative importance of pathogenetic pathways may differ in different tissue and organ contexts. Evidence suggests that vaccination, in addition to protecting against disease, reduces PASC after breakthrough infection although its actual impact remains to be defined. PASC represents a formidable challenge for health care systems and dissecting pathogenetic mechanisms may pave the way to targeted preventive and therapeutic approaches.
AU  - Mantovani,A
AU  - Morrone,MC
AU  - Patrono,C
AU  - Santoro,MG
AU  - Schiaffino,S
AU  - Remuzzi,G
AU  - Bussolati,G
AU  - Covid-19,Commission of the Accademia Nazionale dei Lincei
DO  - 10.1038/s41418-022-01052-6
EP  - 1900
PY  - 2022///
SP  - 1891
TI  - Long Covid: where we stand and challenges ahead.
T2  - Cell Death Differ
UR  - http://dx.doi.org/10.1038/s41418-022-01052-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36071155
VL  - 29
ER  -
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