Imperial College London
Alternate

DrPanagiotisVorkas

Faculty of Medicine, Department of Surgery & Cancer

Research Associate
 
 
 
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Contact

 

p.vorkas

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Qureshi:2017:10.1021/acs.jproteome.6b00894,
author = {Qureshi, MI and Greco, M and Vorkas, PA and Holmest, E and Davies, AH},
doi = {10.1021/acs.jproteome.6b00894},
journal = {Journal of Proteome Research},
pages = {2325--2332},
title = {Application of metabolic profiling to abdominal aortic aneurysm research},
url = {http://dx.doi.org/10.1021/acs.jproteome.6b00894},
volume = {16},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Abdominal aortic aneurysm (AAA) is a complex disease posing diagnostic and therapeutic challenges. Metabonomics may aid in the diagnosis of AAA, determination of individualized risk, discovery of therapeutic targets, and improve understanding of pathogenesis. A systematic review of the diversity and outcomes of existing AAA metabonomic research has been performed. Original research studies applying metabonomics to human aneurysmal disease are included. Seven relevant articles were identified: four studies were based on plasma/serum metabolite profiling, and three studies examined aneurysmal tissue. Aminomalonic acid, guanidinosuccinic acid, and glycerol emerge as potential plasma biomarkers of large aneurysm. Lipid profiling improves predictive models of aneurysm presence. Patterns of metabolite variation associated with AAA relate to carbohydrate and lipid metabolism. Perioperative perturbations in metabolites suggest differential systemic inflammatory responses to surgery, generating hypotheses for adjunctive perioperative therapy. Significant limitations include small study sizes, lack of correction for multiple testing false discovery rates, and single time-point sampling. Metabolic profiling carries the potential to identify biomarkers of AAA and elucidate pathways underlying aneurysmal disease. Statistically and methodologically robust studies are required for validation, addressing the hiatus in understanding mechanisms of aneurysm growth and developing effective treatment strategies.
AU  - Qureshi,MI
AU  - Greco,M
AU  - Vorkas,PA
AU  - Holmest,E
AU  - Davies,AH
DO  - 10.1021/acs.jproteome.6b00894
EP  - 2332
PY  - 2017///
SN  - 1535-3893
SP  - 2325
TI  - Application of metabolic profiling to abdominal aortic aneurysm research
T2  - Journal of Proteome Research
UR  - http://dx.doi.org/10.1021/acs.jproteome.6b00894
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405358500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/50509
VL  - 16
ER  -
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