Imperial College London
Alternate

ProfessorPeterWeinberg

Faculty of Engineering, Department of Bioengineering

Professor in Cardiovascular Mechanics
 
 
 
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Contact

 

+44 (0)20 7594 1517p.weinberg Website

 
 
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Location

 

4.10Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Weinberg:2021:10.1080/21688370.2021.1959243,
author = {Weinberg, P and Warboys, CM},
doi = {10.1080/21688370.2021.1959243},
journal = {Tissue Barriers},
pages = {1--18},
title = {S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability},
url = {http://dx.doi.org/10.1080/21688370.2021.1959243},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Atherosclerosis is characterised by focal accumulations of lipid within the arterial wall, thought to arise from effects of haemodynamic wall shear stress (WSS) on endothelial permeability. Identifying pathways that mediate effects of shear on permeability could therefore provide new therapeutic opportunities. Here we consider whether the sphingosine-1-phosphate (S1P) pathway could constitute such a route. We review effects of S1P in endothelial barrier function, the influence of WSS on S1P production and signalling, the results of trials investigating S1P in experimental atherosclerosis in mice, and associations between S1P levels and cardiovascular disease in humans. Although it seems clear that S1P reduces endothelial permeability and responds to WSS, the evidence that it influences atherosclerosis is equivocal. The effects of specifically pro- and anti-atherosclerotic WSS profiles on the S1P pathway require investigation, as do influences of S1P on the vesicular pathways likely to dominate low density lipoprotein transport across endothelium.
AU  - Weinberg,P
AU  - Warboys,CM
DO  - 10.1080/21688370.2021.1959243
EP  - 18
PY  - 2021///
SN  - 2168-8362
SP  - 1
TI  - S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability
T2  - Tissue Barriers
UR  - http://dx.doi.org/10.1080/21688370.2021.1959243
UR  - https://www.tandfonline.com/doi/full/10.1080/21688370.2021.1959243
UR  - http://hdl.handle.net/10044/1/91598
VL  - 9
ER  -
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