Imperial College London
Alternate

ProfessorPeterWeinberg

Faculty of Engineering, Department of Bioengineering

Professor in Cardiovascular Mechanics
 
 
 
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Contact

 

+44 (0)20 7594 1517p.weinberg Website

 
 
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Location

 

4.10Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Weinberg:2022:10.3389/fbioe.2022.962687,
author = {Weinberg, P and Kandangwa, P and Torii, R and Gatehouse, P and Sherwin, S},
doi = {10.3389/fbioe.2022.962687},
journal = {Fontiers in Bioengineering and Biotechnology},
pages = {1--14},
title = {Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics},
url = {http://dx.doi.org/10.3389/fbioe.2022.962687},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The patchy distribution of atherosclerosis within the arterial system is consistent with a controlling influence of hemodynamic wall shear stress (WSS). Patterns of low, oscillatory and transverse WSS have been invoked to explain the distribution of disease in the aorta. Disease of coronary arteries has greater clinical importance but blood flow in these vessels may be complicated by their movement during the cardiac cycle. Previous studies have shown that time average WSS is little affected by the dynamic geometry, and that oscillatory shear is influenced more. Here we additionally investigate effects on transverse WSS. We also investigate the influence of non-Newtonian blood rheologyas it can influence vortical structure, on which transverse WSS depends; Carreau-Yasuda models were used. WSS metrics were derived from numerical simulations of blood flow in a model of a moving right coronary artery which, together with a subject-specific inflow waveform, was obtained by MR imaging of a healthy human subject in a previous study. The results confirmed that time average WSS was little affected by dynamic motion, and that oscillatory WSS was more affected. They additionally showed that transverse WSS and its non-dimensional analogue, the Cross Flow Index, were affected still further. This appeared to reflect time-varying vortical structures caused by the changes in curvature. The influence of non-Newtonian rheology was significant with some physiologically realistic parameter values, and hence may be important in certain subjects. Dynamic geometry and non-Newtonian rheology should be incorporated into models designed to produce maps of transverse WSS in coronary arteries.
AU  - Weinberg,P
AU  - Kandangwa,P
AU  - Torii,R
AU  - Gatehouse,P
AU  - Sherwin,S
DO  - 10.3389/fbioe.2022.962687
EP  - 14
PY  - 2022///
SN  - 2296-4185
SP  - 1
TI  - Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics
T2  - Fontiers in Bioengineering and Biotechnology
UR  - http://dx.doi.org/10.3389/fbioe.2022.962687
UR  - https://www.frontiersin.org/articles/10.3389/fbioe.2022.962687/full
UR  - http://hdl.handle.net/10044/1/98324
VL  - 10
ER  -
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