Imperial College London
Alternate

ProfessorPeterWhite

Faculty of Medicine, School of Public Health

Professor of Public Health Modelling
 
 
 
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Contact

 

p.white Website

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Story:2019:10.3310/pgfar08090,
author = {Story, A and Garber, E and Aldridge, RW and Smith, CM and Hall, J and Ferenando, G and Possas, L and Hemming, S and Wurie, F and Luchenski, S and Abubakar, I and McHugh, TD and White, PJ and Watson, JM and Lipman, M and Garfein, R and Hayward, AC},
doi = {10.3310/pgfar08090},
journal = {Programme Grants for Applied Research},
pages = {7--75},
title = {Management and control of tuberculosis control in socially complex groups: A research programme including three RCTs},
url = {http://dx.doi.org/10.3310/pgfar08090},
volume = {8},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Socially complex groups, including people experiencing homelessness, prisoners and drug users, have very high levels of tuberculosis, often complicated by late diagnosis and difficulty in adhering to treatment. Objective: To assess a series of interventions to improve tuberculosis control in socially complex groups. Design: A series of observational surveys, evaluations and trials of interventions. Setting: The pan-London Find & Treat service, which supports tuberculosis screening and case management in socially complex groups across London. Participants: Socially complex groups with tuberculosis or at risk of tuberculosis, including people experiencing homelessness, prisoners, drug users and those at high risk of poor adherence to tuberculosis treatment. Interventions and main outcome measures: We screened 491 people in homeless hostels and 511 people in prison for latent tuberculosis infection, human immunodeficiency virus, hepatitis B and hepatitis C. We evaluated an NHS-led prison radiographic screening programme. We conducted a cluster randomised controlled trial (2348 eligible people experiencing homelessness in 46 hostels) of the effectiveness of peer educators (22 hostels) compared with NHS staff (24 hostels) at encouraging the uptake of mobile radiographic screening. We initiated a trial of the use of point-of-care polymerase chain reaction diagnostics to rapidly confirm tuberculosis alongside mobile radiographic screening. We undertook a randomised controlled trial to improve treatment adherence, comparing face-to-face, directly observed treatment with video-observed treatment using a smartphone application. The primary outcome was completion of ≥ 80% of scheduled treatment observations over the first 2 months following enrolment.We assessed the cost-effectiveness of latent tuberculosis screening alongside radiographic screening of people experiencing homelessness. The costs of video-observed treatment and directly observed treatment wer
AU  - Story,A
AU  - Garber,E
AU  - Aldridge,RW
AU  - Smith,CM
AU  - Hall,J
AU  - Ferenando,G
AU  - Possas,L
AU  - Hemming,S
AU  - Wurie,F
AU  - Luchenski,S
AU  - Abubakar,I
AU  - McHugh,TD
AU  - White,PJ
AU  - Watson,JM
AU  - Lipman,M
AU  - Garfein,R
AU  - Hayward,AC
DO  - 10.3310/pgfar08090
EP  - 75
PY  - 2019///
SN  - 2050-4322
SP  - 7
TI  - Management and control of tuberculosis control in socially complex groups: A research programme including three RCTs
T2  - Programme Grants for Applied Research
UR  - http://dx.doi.org/10.3310/pgfar08090
VL  - 8
ER  -
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