Imperial College London
Alternate

ProfessorPeterWhite

Faculty of Medicine, School of Public Health

Professor of Public Health Modelling
 
 
 
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Contact

 

p.white Website

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Halliday:2021:10.3310/eme08050,
author = {Halliday, A and Jain, P and Hoang, L and Parker, R and Tolosa-Wright, M and Masonou, T and Green, N and Boakye, A and Takwoingi, Y and Hamilton, S and Mandagere, V and Fries, A and Coin, L and Deeks, J and White, PJ and Levin, M and Beverley, P and Kon, OM and Lalvani, A},
doi = {10.3310/eme08050},
journal = {Efficacy and Mechanism Evaluation},
pages = {1--160},
title = {New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study},
url = {http://dx.doi.org/10.3310/eme08050},
volume = {8},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:sec id="abs1-1">                  <jats:title>Background</jats:title>                  <jats:p>Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed.</jats:p>               </jats:sec>               <jats:sec id="abs1-2">                  <jats:title>Objective</jats:title>                  <jats:p>To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR)] and existing signatures for the detection of active TB in samples obtained from individuals with suspected active TB.</jats:p>               </jats:sec>               <jats:sec id="abs1-3">                  <jats:title>Design</jats:title>                  <jats:p>Four substudies, each of which used samples from the biobank collected as part of the interferon gamma release assay (IGRA) in the Diagnostic Evaluation of Active TB study, which was a prospective cohort of patients recruited with suspected TB.</jats:p>               </jats:sec>               <jats:sec id="abs1-4">                  <jats:title>Setting</jats:title>                  <jats:p>Secondary care.</jats:p>               </jats:sec>               <jats:sec id="abs1-5">                  <jats:title>Participants</jats:title>                  <jats:p>Adults aged ≥ 16 years presenting as inpatients or outpatients at 12 NHS hospital trusts in London, Slough, Oxford, Leicester and Birmingham, with suspected active TB.</jats:p>               </jats:sec>               <jats:sec id="abs1-6">                  <jats:title>Interventions</jats:title>                  <jats:p>New tests using genome-wide gene expression microarray
AU  - Halliday,A
AU  - Jain,P
AU  - Hoang,L
AU  - Parker,R
AU  - Tolosa-Wright,M
AU  - Masonou,T
AU  - Green,N
AU  - Boakye,A
AU  - Takwoingi,Y
AU  - Hamilton,S
AU  - Mandagere,V
AU  - Fries,A
AU  - Coin,L
AU  - Deeks,J
AU  - White,PJ
AU  - Levin,M
AU  - Beverley,P
AU  - Kon,OM
AU  - Lalvani,A
DO  - 10.3310/eme08050
EP  - 160
PY  - 2021///
SN  - 2050-4365
SP  - 1
TI  - New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study
T2  - Efficacy and Mechanism Evaluation
UR  - http://dx.doi.org/10.3310/eme08050
VL  - 8
ER  -
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