Publications

BibTex format

@article{Rangaka:2022:10.1136/bmjopen-2021-057717,
author = {Rangaka, MX and Hamada, Y and Duong, T and Bern, H and Calvert, J and Francis, M and Clarke, AL and Ghanouni, A and Layton, C and Hack, V and Owen-Powell, E and Surey, J and Sanders, K and Booth, HL and Crook, A and Griffiths, C and Horne, R and Kunst, H and Lipman, M and Mandelbaum, M and White, PJ and Zenner, D and Abubakar, I},
doi = {10.1136/bmjopen-2021-057717},
journal = {BMJ Open},
pages = {1--11},
title = {Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial},
url = {http://dx.doi.org/10.1136/bmjopen-2021-057717},
volume = {12},
year = {2022}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction The successful scale-up of a latent tuberculosis (TB) infection testing and treatment programme is essential to achieve TB elimination. However, poor adherence compromises its therapeutic effectiveness. Novel rifapentine-based regimens and treatment support based on behavioural science theory may improve treatment adherence and completion.Methods and analysis A pragmatic multicentre, open-label, randomised controlled trial assessing the effect of novel short-course rifapentine-based regimens for TB prevention and additional theory-based treatment support on treatment adherence against standard-of-care. Participants aged between 16 and 65 who are eligible to start TB preventive therapy will be recruited in England. 920 participants will be randomised to one of six arms with allocation ratio of 5:5:6:6:6:6: daily isoniazid +rifampicin for 3 months (3HR), routine treatment support (control); 3HR, additional treatment support; weekly isoniazid +rifapentine for 3 months (3HP), routine treatment support; weekly 3HP, additional treatment support ; daily isoniazid +rifapentine for 1 month (1HP), routine treatment support; daily 1HP, additional treatment support. Additional treatment support comprises reminders using an electronic pillbox, a short animation, and leaflets based on the perceptions and practicalities approach. The primary outcome is adequate treatment adherence, defined as taking ≥90% of allocated doses within the pre-specified treatment period, measured by electronic pillboxes. Secondary outcomes include safety and TB incidence within 12 months. We will conduct process evaluation of the trial interventions and assess intervention acceptability and fidelity and mechanisms for effect and estimate the cost-effectiveness of novel regimens. The protocol was developed with patient and public involvement, which will continue throughout the trial.Ethics and dissemination Ethics approval has been obtained from The National Health Service Health Research
AU  - Rangaka,MX
AU  - Hamada,Y
AU  - Duong,T
AU  - Bern,H
AU  - Calvert,J
AU  - Francis,M
AU  - Clarke,AL
AU  - Ghanouni,A
AU  - Layton,C
AU  - Hack,V
AU  - Owen-Powell,E
AU  - Surey,J
AU  - Sanders,K
AU  - Booth,HL
AU  - Crook,A
AU  - Griffiths,C
AU  - Horne,R
AU  - Kunst,H
AU  - Lipman,M
AU  - Mandelbaum,M
AU  - White,PJ
AU  - Zenner,D
AU  - Abubakar,I
DO  - 10.1136/bmjopen-2021-057717
EP  - 11
PY  - 2022///
SN  - 2044-6055
SP  - 1
TI  - Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-057717
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852862800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmjopen.bmj.com/content/12/9/e057717
UR  - http://hdl.handle.net/10044/1/99880
VL  - 12
ER  -

Download

ProfessorPeterWhite

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)