Imperial College London
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DrPeterWinskill

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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p.winskill

 
 
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School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dixon:2021:10.1016/bs.apar.2021.03.003,
author = {Dixon, M and Winskill, P and Harrison, W and Basanez, M-G},
doi = {10.1016/bs.apar.2021.03.003},
journal = {Advances in Parasitology},
pages = {133--217},
title = {Taenia solium taeniasis / cysticercosis: from parasite biology and immunology to diagnosis and control},
url = {http://dx.doi.org/10.1016/bs.apar.2021.03.003},
volume = {112},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Infection with the pork tapeworm (Taenia solium) is responsible for a substantial global  burden  of  disease,  not  only  restricted  to  its impact  on  human  health,  but also resulting in a considerable economic burden to smallholder pig farmers due to pig  cysticercosis  infection.  The  life-cycle,  parasitology  and  immunology  of T. solium are complex, involving pigs(the intermediate host, harbouring the larval metacestode stage), humans(the definitive host, harbouring the adult tapeworm, in  addition  to  acting  as  accidental  intermediate  hosts)  and  the environment  (the source   of   infection   with   eggs/proglottids). We   review the   parasitology, immunology, and epidemiology of  the  infection associated  with each  of  the T. solium life-cycle stages, including the pre-adult/adult tapeworm responsible for human  taeniasis;  post-oncosphere  and  cysticercus  associated  with  porcine  and human cysticercosis, and the biological characteristics of eggs in the environment. We  discuss the  burden  associated, in  endemic  settings, with  neurocysticercosis (NCC) in humans, and the broader cross-sectoral economic impact associated both with  NCC  and porcine  cysticercosis,  the  latter impacting food-value chains. Existing tools for diagnostics and control interventions that target different stages of  the T.  solium transmission  cycle are reviewed and  their  limitations  discussed. Currently, no  national T.  solium control  programmes have  been  established  in endemic areas, with further work required to identify optimal strategies according to  epidemiological  setting.  There is increasing evidence suggesting that  cross-sectoral interventions which  target the  parasite  in both  the  human  and  pig  host provide the  most effective  approaches  for  achieving  control and ultimately elimination. We  discuss  future  avenues  for  research  on T. soliumto  support  the attainement  of the goals  proposed  in  the revised  World  Heal
AU  - Dixon,M
AU  - Winskill,P
AU  - Harrison,W
AU  - Basanez,M-G
DO  - 10.1016/bs.apar.2021.03.003
EP  - 217
PY  - 2021///
SN  - 0065-308X
SP  - 133
TI  - Taenia solium taeniasis / cysticercosis: from parasite biology and immunology to diagnosis and control
T2  - Advances in Parasitology
UR  - http://dx.doi.org/10.1016/bs.apar.2021.03.003
UR  - http://hdl.handle.net/10044/1/89141
VL  - 112
ER  -
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