Publications
181 results found
Ziprin P, Ridgway PF, Pfistermüller KLM, et al., 2009, ICAM-1 mediated tumor-mesothelial cell adhesion is modulated by IL-6 and TNF-α:: A potential mechanism by which surgical trauma increases peritoneal metastases, CELL COMMUNICATION AND ADHESION, Vol: 10, Pages: 141-154, ISSN: 1541-9061
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- Citations: 56
Shalhoub J, Naughton P, Ziprin P, 2009, Don't Overlook Minimally Invasive Colorectal Cancer Surgery Response, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 38, Pages: 137-138, ISSN: 1078-5884
Shalhoub J, Naughton P, Lau N, et al., 2009, Concurrent Colorectal Malignancy and Abdominal Aortic Aneurysm: A Multicentre Experience and Review of the Literature, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 37, Pages: 544-556, ISSN: 1078-5884
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- Citations: 27
Fox J, Willberg C, Ziprin P, et al., 2009, The role of the gut mucosa in protection from HIV-1 in highly exposed persistently seronegative individuals (HEPS), HIV MEDICINE, Vol: 10, Pages: 5-5, ISSN: 1464-2662
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- Citations: 1
Tan E, Gouvas N, Nicholls RJ, et al., 2009, Diagnostic precision of carcinoembryonic antigen in the detection of recurrence of colorectal cancer, SURGICAL ONCOLOGY-OXFORD, Vol: 18, Pages: 15-24, ISSN: 0960-7404
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- Citations: 163
Katsuno H, Zacharakis E, Aziz O, et al., 2008, Does the Presence of Circulating Tumor Cells in the Venous Drainage of Curative Colorectal Cancer Resections Determine Prognosis? A Meta-Analysis, ANNALS OF SURGICAL ONCOLOGY, Vol: 15, Pages: 3083-3091, ISSN: 1068-9265
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- Citations: 42
Clarka J, Cleator S, Goldin R, et al., 2008, Treatment of primary rectal squamous cell carcinoma by primary chemoradiotherapy: Should surgery still be considered a standard of care?, EUROPEAN JOURNAL OF CANCER, Vol: 44, Pages: 2340-2343, ISSN: 0959-8049
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- Citations: 42
Zacharakis E, Shalhoub J, Selvapatt N, et al., 2008, Revisional laparoscopic parastomal hernia repair, JSLS, Journal of the Society of Laparoendscopic Surgeons, Vol: 12, Pages: 403-406, ISSN: 1086-8089
Background:We herein report a laparoscopically performed re-do operation on a patient who had previously undergone a laparoscopic parastomal hernia repair.Case Report:We describe the case of a 71-year-old patient who presented within 3 months of her primary laparoscopic parastomal hernia repair with recurrence. On relaparoscopy, dense adhesions to the mesh were found, and the mesh had migrated into the hernia sac. This had allowed loops of small bowel to herniate into the sac. The initial part of the procedure involved the lysis of adhesions. A piece of Gore-Tex DualMesh with a central keyhole and a radial slit was cut so that it could provide at least 3 cm to 5 cm of overlap of the fascial defect. The tails of the mesh were wrapped around the bowel, and the mesh was secured to the margins of the hernia with circumferential metal tacking and 4 transfascial sutures. The patient remains in satisfactory condition and no recurrence or any surgery-related problem has been observed during 8 months of follow-up.Conclusion:Revisional laparoscopic repair of parastomal hernias seems feasible and has been shown to be safe and effective in this case. The success of this approach depends on longer follow-up reports and standardization of the technical elements.
Rekhraj S, Aziz O, Zacharakis E, et al., 2008, Peritoneal cytology in colorectal cancer: incidence and prognostic value, AMERICAN JOURNAL OF SURGERY, Vol: 196, Pages: 617-618, ISSN: 0002-9610
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- Citations: 2
Ziprin P, Prabhudesai SG, Abrahams S, et al., 2008, Transabdominal Preperitoneal Laparoscopic Approach for the Treatment of Sportsman's Hernia, JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, Vol: 18, Pages: 669-672, ISSN: 1092-6429
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- Citations: 27
Kinross J, Seitz A, Prabhudesai S, et al., 2008, Metabolic profiling of FGF-2 induced chemo-resistance in a sw620 colon cancer cell line, Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 937-937, ISSN: 0007-1323
Zacharakis E, Hettige R, Purkayastha S, et al., 2008, Laparoscopic parastomal hernia repair: A description of the technique and initial results, SURGICAL INNOVATION, Vol: 15, Pages: 85-89, ISSN: 1553-3506
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- Citations: 6
Prabhudesai SG, Gould S, Rekhraj S, et al., 2008, Artificial neural networks: Useful aid in diagnosing acute appendicitis, WORLD JOURNAL OF SURGERY, Vol: 32, Pages: 305-309, ISSN: 0364-2313
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- Citations: 34
Clark J, Ziprin P, 2008, Local excision and transanal endoscopic microsurgery in the management of rectal cancer with a focus on early carcinoma, FUTURE ONCOLOGY, Vol: 4, Pages: 113-124, ISSN: 1479-6694
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- Citations: 3
Rekhraj S, Aziz O, Prabhudesai S, et al., 2008, Can intra-operative intraperitoneal free cancer cell detection techniques identify patients at higher recurrence risk following curative colorectal cancer resection: a meta-analysis, ANNALS OF SURGICAL ONCOLOGY, Vol: 15, Pages: 60-68, ISSN: 1068-9265
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- Citations: 36
Zacharakis E, Papadopoulos V, Athanasiou T, et al., 2008, An unusual presentation of Meckel diverticulum as strangulated femoral hernia, SOUTHERN MEDICAL JOURNAL, Vol: 101, Pages: 96-98, ISSN: 0038-4348
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- Citations: 7
Zacharakis E, Freilich S, Rekhraj S, et al., 2007, Transanal endoscopic microsurgery for rectal tumors: the St. Mary's experience, AMERICAN JOURNAL OF SURGERY, Vol: 194, Pages: 694-698, ISSN: 0002-9610
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- Citations: 29
Alkhamesi NA, Roberts G, Ziprin P, et al., 2007, Induction of Proteases in Peritoneal Carcinomatosis, the Role of ICAM-1/CD43 Interaction., Biomark Insights, Vol: 2, Pages: 377-384, ISSN: 1177-2719
INTRODUCTION: The development of peritoneal metastases is a significant clinical issue in the treatment of abdominal cancers and is associated with poor prognosis. We have previously shown that ICAM-1-CD43 interaction plays a significant role in tumor adhesion. However, an invasive phenotype is critical to establish tumor progression via cell associated and secreted proteases including matrix metalloproteinases. High metalloproteinases level significantly enhanced metastasis phenotype on tumors, a detrimental effect on surgical outcome. We investigated the role of direct and indirect signaling between the mesothelium and the tumor cells in enhancing tumor invasion and possible therapeutic intervention. METHODS: Mesothelial cells were enzymatically derived from human omental tissue and implanted in 24 wells plates. Colorectal cancer cells were then introduced and allowed a direct and an indirect contact with the mesothelial layer. Anti-ICAM antibodies, anti-CD43 antibodies, and heparin were used to block MMP production. Gelatin zymography was performed on the supernatant to detect MMPs activity. RESULTS: MMP production was observed in mesothelial and tumor cells. Direct contact between cell types enhanced MMP9 and 2 (p < 0.05). Indirect contact also stimulate MMPs but at a lower degree. ICAM-1 blocking antibodies attenuated MMP production in direct contact to that observed in the indirect. Heparin introduction achieved a similar outcome. CONCLUSIONS: ICAM-1-CD43 interaction plays a vital role in tumor cells-peritoneum adhesion and invasion, which is manifested by the increased production of MMPs leading to tumor invasion and peritoneal loco-regional. Blocking this interaction with heparin can provide a new therapeutic option.
Rekhraj S, Aziz O, Prabhudesai S, et al., 2007, Does the detection of intraperitoneal free cancer cells predict recurrence in patients undergoing curative colorectal cancer resection, European Society of Coloproctology (ESCP) Annual Scientific Meeting
Rekhraj S, Aziz O, Athanasiou T, et al., 2007, Are intraperitoneal free cancer cell detection techniques useful in identifying patients at higher recurrence risk following curative colorectal cancer resection?, KL International Breast and Colorectal Cancer Congress
Prabhudesai SG, Rekhraj S, Roberts G, et al., 2007, Apoptosis and chemo-resistance in colorectal cancer, JOURNAL OF SURGICAL ONCOLOGY, Vol: 96, Pages: 77-88, ISSN: 0022-4790
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- Citations: 38
Prabhudesai SG, Leong J, Ziprin P, 2007, Major abdominal surgery increases plasma levels of vascular endothelial growth factor: Open more so than minimally invasive methods, ANNALS OF SURGERY, Vol: 246, Pages: 160-161, ISSN: 0003-4932
Rekhraj S, Kinross J, Prabhudesai S, et al., 2007, Intraperitoneal chemotherapy as first-line treatment in the management of epithelial ovarian cancer, MINI-REVIEWS IN MEDICINAL CHEMISTRY, Vol: 7, Pages: 509-517, ISSN: 1389-5575
Rekhraj S, Prabhudesai S, Roberts G, et al., 2007, Tumour-Mesothelial cell interactions potentiate peritoneal metastasis in Gastric cancer – the role of Interleukin-6, Association of Surgeons of Great Britain & Ireland (ASGBI) Annual Meeting, 'A First Class Service'
Bailey C, Negus R, Morris A, et al., 2007, Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer, CLINICAL & EXPERIMENTAL METASTASIS, Vol: 24, Pages: 121-130, ISSN: 0262-0898
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- Citations: 142
Rekhraj S, Roberts G, Prabhudesai S, et al., 2007, Tumour-Mesothelial cell interaction upregulates MMP2 and MMP9 via a PI3Kinase-dependent pathway – a mechanism for development of peritoneal metastasis, Society of Academic & Research Surgery (SARS) Conference
Watson A, Ziprin P, Chadwick S, 2006, TAPP repair for inguinal hernias--a new composite mesh technique., Ann R Coll Surg Engl, Vol: 88
Tilney HS, Constantinides VA, Heriot AG, et al., 2006, Comparison of laparoscopic and open ileocecal resection for Crohn's disease: a metaanalysis, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 20, Pages: 1036-1044, ISSN: 0930-2794
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- Citations: 135
Jacklin RK, Ridgway PF, Ziprin P, et al., 2006, Optimising preoperative diagnosis in phyllodes tumour of the breast, JOURNAL OF CLINICAL PATHOLOGY, Vol: 59, Pages: 454-459, ISSN: 0021-9746
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- Citations: 89
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