Publications
181 results found
Rekhraj S, Roberts G, Alkhamesi N, et al., 2005, Bi-directional upregulation of MMP2 and MMP9 in peritoneal metastasis, ASGBI NW Thames (Regional) Meeting
Alkhamesi NA, Ziprin P, Pfistermuller K, et al., 2005, ICAM-1 mediated peritoneal carcinomatosis, a target for therapeutic intervention, CLINICAL & EXPERIMENTAL METASTASIS, Vol: 22, Pages: 449-459, ISSN: 0262-0898
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- Citations: 49
Rekhraj S, Roberts G, Layfield D, et al., 2005, Bi-directional upregulation of MMP2 and MMP9 following tumour-mesothelial contact, National Cancer Research Institute (NCRI) Cancer Conference
Purkayastha S, Tekkis P, Athanasiou T, et al., 2005, A comparison of open <i>vs</i>. laparoscopic abdominal rectopexy for full-thickness rectal prolapse:: A meta-analysis, DISEASES OF THE COLON & RECTUM, Vol: 48, Pages: 1930-1940, ISSN: 0012-3706
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- Citations: 69
Alkhamesi NA, Ziprin P, 2005, Impact of video colonoscopy on stage and outcome of patients with symptomatic colorectal cancer, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 19, Pages: 860-860, ISSN: 0930-2794
Ridgway PF, Ziprin P, Alkhamesi N, et al., 2005, Hypoxia augments gelatinase activity in a variety of adenocarcinomas <i>in vitro</i>, JOURNAL OF SURGICAL RESEARCH, Vol: 124, Pages: 180-186, ISSN: 0022-4804
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- Citations: 16
Ridgway PF, Ziprin P, Peck DH, et al., 2005, Hypoxia increases reepithelialization via an αvβ6-dependent pathway, WOUND REPAIR AND REGENERATION, Vol: 13, Pages: 158-164, ISSN: 1067-1927
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- Citations: 20
Ridgway PF, Jacklin RK, Ziprin P, et al., 2004, Perioperative diagnosis of cystosarcoma phyllodes of the breast may be enhanced by MIB-1 index, JOURNAL OF SURGICAL RESEARCH, Vol: 122, Pages: 83-88, ISSN: 0022-4804
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- Citations: 13
Alkhamnesi NA, Ziprin P, Pfistermuller K, et al., 2004, CD43-intercellular adhesion molecule (ICAM) 1 interaction: a mechanism that can be targeted to block intraperitoneal metastasis, 4th Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: JOHN WILEY & SONS LTD, Pages: 1206-1206, ISSN: 0007-1323
Ziprin P, Alkhamesi NA, Ridgway PF, et al., 2004, Tumour-expressed CD43 (sialophorin) mediates tumour-mesothelial cell adhesion, BIOLOGICAL CHEMISTRY, Vol: 385, Pages: 755-761, ISSN: 1431-6730
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- Citations: 37
Ziprin P, Clarke J, 2004, Effect of neoadjuvant chemoradiotherapy on angiogenesis in oesophageal cancer (Br J Surg 2003; 90:1373-1378), BRITISH JOURNAL OF SURGERY, Vol: 91, Pages: 253-254, ISSN: 0007-1323
Alkhamesi NA, Ziprin P, Peck DH, et al., 2003, Molecular mechanisms involved in enhancing peritoneal locoregional metastasis., AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 6180S-6180S, ISSN: 1078-0432
Ziprin P, Ridgway PF, Peck DH, et al., 2003, Laparoscopic-type environment enhances mesothelial cell fibrinolytic activity in vitro via a down-regulation of plasminogen activator inhibitor-1 activity., Surgery, Vol: 134, Pages: 758-765, ISSN: 0039-6060
BACKGROUND: Fewer intraperitoneal adhesions have been observed after laparoscopic surgery compared with conventional techniques. The aim of this study is to assess the effect of the pneumoperitoneum on mesothelial cell fibrinolytic activity by use of an in vitro model. METHODS: Human peritoneal mesothelial cells were seeded onto 24-well plates and incubated in carbon dioxide or helium at 5 mm Hg for 4 hours or standard culture conditions. Supernatant was removed for analysis at 0, 24, 48, and 72 hours after gas incubation and analyzed for plasminogen activator activity, total tissue plasminogen activator (tPA), and total plasminogen activator inhibitor-1 (PAI-1) concentrations by use of an enzyme-linked immunosorbent assay. The effect of different insufflation pressures (0, 7, and 14 mm Hg) was also examined. RESULTS: Enhanced plasminogen activator activity was observed at 48 hours and 72 hours from cells exposed to CO(2) (P<.04 each) and helium (P<.05 each) compared with control. This was associated with a decrease in PAI-1 concentrations at 48 and 72 hours in both the CO(2) and helium groups compared with control (P<.03 each, CO(2) vs control; and P<.04 each, helium vs control). No changes in tPA levels were observed. Changes in insufflation pressures did not affect plasminogen activator activity. CONCLUSIONS: These results suggest that incubation of human mesothelial cells with both CO(2) and helium in the absence of oxygen enhances mesothelial cell fibrinolytic activity because of a reduction in PAI-1 concentrations. These changes may participate in the observed reduction in adhesions after laparoscopic surgery relative to open surgery.
Ziprin P, Ridgway PF, Peck DH, et al., 2003, Laparoscopic enhancement of tumor cell binding to the peritoneum is inhibited by anti-intercellular adhesion molecule-1 monoclonal antibody, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 17, Pages: 1812-1817, ISSN: 0930-2794
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- Citations: 10
Alkhamesi N, Ziprin P, Pfistermuller K, et al., 2003, Role of therapeutic intervention in peritoneal carcinomatosis via an ICAM-1 dependent mechanism, Annual Meeting of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 6-6, ISSN: 0007-1323
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- Citations: 3
Ridgway PF, Ziprin P, Jones TL, et al., 2003, Laparoscopic staging of pancreatic tumors induces increased invasive capacity <i>in vitro</i>, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 17, Pages: 306-310, ISSN: 0930-2794
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- Citations: 11
Ziprin P, Ridgway PF, Peck DH, et al., 2002, The theories and realities of port-site metastases: A critical appraisal, JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, Vol: 195, Pages: 395-408, ISSN: 1072-7515
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- Citations: 52
Ridgway PF, Ziprin P, Datta VK, et al., 2002, Laboratory-based validation of a novel suture technique for wound closure, ANNALS OF PLASTIC SURGERY, Vol: 49, Pages: 291-296, ISSN: 0148-7043
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- Citations: 13
Ziprin P, Bethune R, Benoist S, et al., 2002, The role of transanal endoscopic microsurgery in the management of malignant rectal tumours, BRITISH JOURNAL OF SURGERY, Vol: 89, Pages: 11-12, ISSN: 0007-1323
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- Citations: 1
Ridgway PF, Ziprin P, Paraskeva PA, et al., 2002, Re-epithelialization of cutaneous wounds is augmented by hypoxia, BRITISH JOURNAL OF SURGERY, Vol: 89, Pages: 31-31, ISSN: 0007-1323
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- Citations: 1
Ridgway PF, Olsen S, Ziprin P, et al., 2002, Hypoxia induces augmented malignant potential via nuclear factor κB-mediated metalloprotease upregulation in a variety of adenocarcinomas, BRITISH JOURNAL OF SURGERY, Vol: 89, Pages: 641-641, ISSN: 0007-1323
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- Citations: 1
Ziprin P, Ridgway PF, Peck D, et al., 2002, Tumour necrosis factor a enhances tumour cell adhesion to the mesothelium via upregulation of intercellular adhesion molecule 1: a mechanism by which surgical trauma increases tumour recurrence, BRITISH JOURNAL OF SURGERY, Vol: 89, Pages: 655-655, ISSN: 0007-1323
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- Citations: 1
Ridgway PF, Smith A, Ziprin P, et al., 2002, Pneumoperitoneum augmented tumor invasiveness is abolished by matrix metalloproteinase blockade, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 16, Pages: 533-536, ISSN: 0930-2794
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- Citations: 24
Ziprin P, Darzi A, Burns JW, et al., 2002, Invited Commentary, Diseases of the Colon and Rectum, Vol: 45, Pages: 341-344, ISSN: 0012-3706
Ziprin P, Darzi AW, 2002, Monopolar electrosurgery: Risks and their reduction, Problems in General Surgery, Vol: 19, Pages: 18-23, ISSN: 0739-8328
Many different hazards have been identified since the introduction of electrosurgery by Harvey Cushing in 1928 and with the development of minimal access surgery a number of new safety issues have been brought to light. This article describes the principles of monopolar diathermy together with the dangers associated with its use and discusses the measures that can be taken to avoid or reduce these risks.
Ziprin P, Peck D, Darzi A, 2001, Enhanced binding of tumour cells to mesothelium following exposure to pneumoperitoneum, BRITISH JOURNAL OF SURGERY, Vol: 88, Pages: 762-762, ISSN: 0007-1323
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- Citations: 1
Ziprin P, Ridgway P, Peck D, et al., 2001, Hyaluronan inhibits the adherence of a colon adenocarcinoma cell line, SW1222, to the mesothelium <i>in vitro</i>, BRITISH JOURNAL OF SURGERY, Vol: 88, Pages: 56-56, ISSN: 0007-1323
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- Citations: 3
Benoist S, Taffinder N, Gould S, et al., 2001, Transanal endoscopic microsurgery; a forgotten minimally invasive technique, Gastroenterol Clin Biol, Vol: 25, Pages: 369-374
Ziprin P, Smith S, Salerno G, et al., 2000, Two cases of merkel cell tumour arising in patients with chronic lymphocytic leukaemia., Br J Dermatol, Vol: 142, Pages: 525-528, ISSN: 0007-0963
Chronic lymphocytic leukaemia (CLL) has been associated with an increased incidence of second neoplasms, especially skin cancers such as basal and squamous cell carcinomas. No association with the rarer skin cancer, the Merkel cell tumour (MCT), has previously been reported. Two patients with MCT had a previous diagnosis of CLL. MCT is an aggressive skin cancer, as up to 45% of patients have lymph node involvement at presentation and 5-year disease-free survival is as low as 30%. It is most commonly found on sun-exposed areas of the body, and ultraviolet radiation together with drug-induced or CLL-induced immunosuppression may be the underlying mechanism in the observed relationship between CLL and other skin cancers.
Caldicott DG, Ziprin P, Morgan R, 2000, Transhepatic insertion of a metallic stent for the relief of malignant afferent loop obstruction., Cardiovasc Intervent Radiol, Vol: 23, Pages: 138-140, ISSN: 0174-1551
A 65-year-old man with a polya gastrectomy presented with biliary obstruction. Percutaneous cholangiography indicated strictures of the distal common bile duct and afferent duodenal loop due to an inoperable carcinoma of the head of the pancreas. The patient was unfit for bypass surgery, and a previous gastrectomy precluded endoscopic intervention. Successful palliation of the biliary obstruction was achieved by placing metallic stents across the duodenal and biliary strictures via the transhepatic route. The use of stents for gastrointestinal stricture is reviewed.
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