Imperial College London
Paul Ziprin

Paul Ziprin

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3312 7635p.ziprin

 
 
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Assistant

 

Ms Caroline Hurley +44 (0)20 3312 2124

 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moussa:2020:eurheartj/ehaa069,
author = {Moussa, O and Ardissino, M and Heaton, T and Tang, A and Khan, O and Ziprin, P and Darzi, A and Collins, P and Purkayastha, S},
doi = {eurheartj/ehaa069},
journal = {European Heart Journal},
pages = {2660--2667},
title = {Effect of bariatric surgery on long-term cardiovascular outcomes: a nationwide nested cohort study},
url = {http://dx.doi.org/10.1093/eurheartj/ehaa069},
volume = {41},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS: This study aims to evaluate the long-term effect of bariatric surgery on cardiovascular outcomes of patients with obesity. METHODS AND RESULTS: A nested cohort study was carried out within the Clinical Practice Research Datalink. The study cohort included the 3701 patients on the database who had undergone bariatric surgery and 3701 age, gender, and body mass index-matched controls. The primary endpoint was the composite of fatal or non-fatal myocardial infarction and fatal or non-fatal ischaemic stroke. Secondary endpoints included fatal or non-fatal myocardial infarction alone, fatal or non-fatal ischaemic stroke alone, incident heart failure, and mortality. The median follow-up achieved was 11.2 years. Patients who had undergone bariatric surgery had a significantly lower occurrence of major adverse cardiovascular events [hazard ratio (HR) 0.410, 95% confidence interval (CI) 0.274-0.615; P < 0.001]. This was mainly driven by a reduction in myocardial infarction (HR 0.412, 95% CI 0.280-0.606; P < 0.001) and not in acute ischaemic stroke (HR 0.536, 95% CI 0.164-1.748; P = 0.301). A reduction was also observed in new diagnoses of heart failure (HR 0.403, 95% CI 0.181-0.897; P = 0.026) and mortality (HR 0.254, 95% CI 0.183-0.353; P < 0.001). CONCLUSION: The results of this large, nationwide cohort study support the association of bariatric surgery with lower long-term risk of major cardiovascular events and incident heart failure in patients with obesity.
AU  - Moussa,O
AU  - Ardissino,M
AU  - Heaton,T
AU  - Tang,A
AU  - Khan,O
AU  - Ziprin,P
AU  - Darzi,A
AU  - Collins,P
AU  - Purkayastha,S
DO  - eurheartj/ehaa069
EP  - 2667
PY  - 2020///
SN  - 0195-668X
SP  - 2660
TI  - Effect of bariatric surgery on long-term cardiovascular outcomes: a nationwide nested cohort study
T2  - European Heart Journal
UR  - http://dx.doi.org/10.1093/eurheartj/ehaa069
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32188981
UR  - https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa069/5809084
UR  - http://hdl.handle.net/10044/1/81859
VL  - 41
ER  -
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