Imperial College London
Paul Ziprin

Paul Ziprin

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3312 7635p.ziprin

 
 
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Assistant

 

Ms Caroline Hurley +44 (0)20 3312 2124

 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gomara:2020:10.1038/s41598-020-71404-0,
author = {Gomara, MJ and Perez, Y and Gomez-Gutierrez, P and Herrera, C and Ziprin, P and Martinez, JP and Meyerhans, A and Perez, JJ and Haro, I},
doi = {10.1038/s41598-020-71404-0},
journal = {Scientific Reports},
pages = {1--14},
title = {Importance of structure-based studies for the design of a novel HIV-1 inhibitor peptide},
url = {http://dx.doi.org/10.1038/s41598-020-71404-0},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater inhibitory potencies in cellular and mucosal tissue pre-clinical models than the parent sequence and the retro-enantio shows a strengthened proteolytic stability. Since HIV-1 fusion inhibitor peptides need to be embedded in the membrane to properly interact with their viral target, the structural features were determined by NMR spectroscopy in micelles and solved by using restrained molecular dynamics calculations. Both parent and retro-enantio peptides demonstrate a topology compatible with a shared helix–turn–helix conformation and assemble similarly in the membrane maintaining the active conformation needed for its interaction with the viral target site. This study represents a straightforward approach to design new targeted peptides as HIV-1 fusion inhibitors and lead us to define a retro-enantio peptide as a good candidate for pre-exposure prophylaxis against HIV-1.
AU  - Gomara,MJ
AU  - Perez,Y
AU  - Gomez-Gutierrez,P
AU  - Herrera,C
AU  - Ziprin,P
AU  - Martinez,JP
AU  - Meyerhans,A
AU  - Perez,JJ
AU  - Haro,I
DO  - 10.1038/s41598-020-71404-0
EP  - 14
PY  - 2020///
SN  - 2045-2322
SP  - 1
TI  - Importance of structure-based studies for the design of a novel HIV-1 inhibitor peptide
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-71404-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000608581100015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41598-020-71404-0
UR  - http://hdl.handle.net/10044/1/87562
VL  - 10
ER  -
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