Publications
428 results found
Beirne P, Pantelidis P, Charles P, et al., 2009, Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 1376-1382, ISSN: 0903-1936
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- Citations: 55
Adams K, Shah PL, Edmonds, et al., 2009, Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis., Thorax, Vol: 9, Pages: 757-762
BACKGROUND: Endobronchial ultrasound (EBUS) with transbronchial needle aspiration (TBNA) is becoming widely used for mediastinal lymph node staging in patients with known or suspected lung cancer. While a substantial number of case series have evaluated test performance of this investigation, the small sample sizes limited the ability to accurately evaluate the precision of EBUS-TBNA as a staging modality. A systematic review was performed of published studies evaluating EBUS-TBNA for mediastinal lymph node staging to ascertain the pooled sensitivity and specificity of this investigation. METHODS: A literature search was constructed and performed by a professional medical librarian to identify the literature from 1960 to February 2008. Pooled specificity and sensitivity was estimated from the extracted data with an exact binomial rendition of the bivariate mixed-effects regression model. RESULTS: Of 365 publications, 25 were identified in which EBUS-TBNA was specifically focused on mediastinal node staging. Of these, only 10 had data suitable for extraction and analysis. The overall test performance was excellent with an area under the summary receiver operating characteristics curve of 0.99 (95% CI 0.96 to 1.00); similarly, EBUS-TBNA had excellent pooled specificity of 1.00 (95% CI 0.92 to 1.00) and good pooled sensitivity of 0.88 (95% CI 0.79 to 0.94). CONCLUSIONS: EBUS-TBNA has excellent overall test performance and specificity for mediastinal lymph node staging in patients with lung cancer. The results compare favourably with published results for computed tomography and positron emission tomography.
Adams K, Shah P, Edmond L, et al., 2009, Endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with non-small cell lung cancer: systematic review and meta-analysis, LUNG CANCER, Vol: 63, Pages: S21-S22, ISSN: 0169-5002
Shah P, 2009, Transbronchial fine needle aspiration, Oxford Desk Reference Respiratory Medcine, Editors: Maskell, Millar, Oxford, UK, Publisher: Oxford University Press, Pages: 316-317, ISBN: 978-0-19-923912-2
Kemp SV, Polkey MI, Shah PL, 2009, The epidemiology, etiology, clinical features and natural history of emphysema, Thoracic Surgical Clinics: Update on surgical and endoscopic management of emphysema, Editors: Choong, Fergusuon, Pennsylvania, USA, Publisher: WB Saunders co, Pages: 149-158, ISBN: 978-1-4377-0552-2
Shah P, Fiterman J, McEvoy C, et al., 2009, Safety of Bronchial Thermoplasty (BT) in Patients with Severe, Symptomatic Asthma: Positive Safety Profile in the AIR2 Trial., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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- Citations: 2
Edmonds L, Adams KJ, Shah P, et al., 2008, TEST PERFORMANCE OF ENDOBRONCHIAL ULTRASOUND AND TRANSBRONCHIAL NEEDLE ASPIRATION BIOPSY FOR MEDIASTINAL STAGING IN PATIENTS WITH LUNG CANCER: SYSTEMATIC REVIEW AND META-ANALYSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A68-A68, ISSN: 0040-6376
Polkey MI, Shah PL, 2008, Surgical and other mechanical procedures, Asthma and COPD: Basic Mechanisms and Clinical Management, Pages: 723-728, ISBN: 9780123740014
Although drugs, together with pulmonary rehabilitation, will form the mainstay of treatment for most patients with chronic obstructive pulmonary disease (COPD) as the lung destruction progresses, these therapies become insufficiently effective for a minority of patients who may then be prepared to consider a surgical treatment. Asthma, being a condition characterized by variable airflow obstruction, is seldom suitable to a surgical approach although the experimental approach of thermoplasty have been discussed in this chapter. Bronchial thermoplasty is a novel approach in the treatment of asthma, which targets smooth muscle within the airways. Bronchial thermoplasty uses low energy radio frequency to ablate the smooth muscle. The epithelium, mucous glands, and nerves appear to regenerate but there is permanent reduction in the smooth muscle bulk. The NETT study is by far the biggest study to assess lung volume reduction surgery (LVRS); briefly after pulmonary rehabilitation 1218 were randomized to receive either LVRS or continued medical care. Surgical patients were more likely to achieve an improved 6-min walk distance and exhibited an approximately 30% reduction in exacerbations. The current position for surgical LVRS is that it may best be described as useful only in patients with the most favorable radiological appearances, who are a minority of emphysema patients. Even so the operation is confined to those patients willing to accept the perioperative mortality but who meet the safety criteria.
Carbone RG, Terracini B, Marinaccio A, et al., 2008, Asbestos, pleural mesothelioma,and mortality in Italy., J Occup Environ Hyg, Vol: 5, Pages: D55-D56
Shah PL, 2008, Flexible bronchoscopy, Medicine, Vol: 36, Pages: 151-154, ISSN: 1357-3039
Bronchoscopy is an essential tool in respiratory medicine, which allows visualization and sampling from the main airways. It has an important role in the evaluation of suspected lung cancer, interstitial lung disease, persistent infection and the assessment of new pulmonary infiltrates in immunocompromised patients. It is a very safe technique which can be performed with or without conscious sedation. Recent developments have ranged from the improvement in image quality to integration of ultrasound. This has increased diagnostic sensitivity and facilitated image-guided biopsies of masses beyond the airways. The therapeutic role of bronchoscopy is also expanding from lung cancer to airways disease. © 2007 Elsevier Ltd. All rights reserved.
Chua F, Shah P, 2008, Haemoptysis, Oxford Desk Reference Critical Care, Editors: Waldmann, Soni, Rhodes, Oxford, UK, Publisher: Oxford University Press, Pages: 270-271, ISBN: 978-0-19-922958-1
Shah PL, 2008, Diaphragm & Phrenic Nerve, Gray's Anatomy, Editors: Standring, london, UK, Publisher: Elsevier, Churchill Livingstone, Pages: 1081-1086, ISBN: 9780443071683
Shah PL, 2008, Pleura, Lungs, Trachea & Bronchi., Gray's Anatomy, Editors: Standring, London, UK, Publisher: Elsevier, Churchill Livingstone, Pages: 1063-1086, ISBN: 9780443071683
Shah PL, Spratt J, 2008, Mediastinum, Gray's Anatomy, Editors: Standring, London, UK, Publisher: Elsevier, Churchill Livingstone, Pages: 977-994, ISBN: 9780443071683
Proudfoot A, Melley D, Shah PL, 2008, Role of thrombolysis in haemodynamically stable patients with pulmonary embolism., Thorax, Vol: 63, Pages: 853-854
Polkey MI, Shah PL, 2008, Surgical and other mechanical procedures., Asthma & COPD, Editors: Barnes, Drazen, Rennard, Thomson, London, UK, Publisher: Elsevier, Pages: 723-728, ISBN: 978-0-12-374001-4
Carbone RG, Terracini B, Marinaccio A, et al., 2008, Asbestos, pleural mesothelioma,and mortality in Italy., J Occup Environ Hyg, Vol: 5, Pages: D55-D56
Pavord ID, Cox G, Thomson NC, et al., 2007, Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 1185-1191, ISSN: 1073-449X
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- Citations: 331
Shah PL, 2007, Epidemiology, Clinical Considerations and Prognosis of Lung Cancer., Contemporary issues in cancer imaging: Lung Cancer, Editors: Desai, Cambridge, UK, Publisher: Cambridge University Press, Pages: 1-11, ISBN: 978-0-521-87202-7
Pavord ID, Cox G, Thomson NC, et al., 2007, Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma, Am J Respir Crit Care Med, Vol: 176, Pages: 1185-1191
Shah P, 2007, Clinical Considerations in Lung Cancer, LUNG CANCE R, Publisher: CAMBRIDGE UNIV PRESS, Pages: 1-11
Cetti E, Nicholson AG, Singh S, et al., 2006, A comparison of autofluorescence bronchoscopy and videobronchoscopy for the detection of pre-invasive lesions in patients with possible lung cancer, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II14-II14, ISSN: 0040-6376
Lee B, Chua F, Gareeboo S, et al., 2006, Non-invasive ventilation: Evidence of efficacy as maximal therapy in acute respiratory failure outside HDU/ICU, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II116-II116, ISSN: 0040-6376
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- Citations: 1
Singh S, Lai D, Davies G, et al., 2006, The role of transbronchial needle aspiration in an integrated care pathway for assessment of patients with suspected lung cancer, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II14-II14, ISSN: 0040-6376
Cetti E, Wells AU, Nicholson AG, et al., 2006, Interobserver variation and the effect of experience in the diagnosis of lung cancer with a videobronchoscope/autofluorescence system, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II101-II102, ISSN: 0040-6376
Cetti EJ, Polkey MI, Kon OM, et al., 2006, Bronchosocpic Techiques for treating emphysema, Clinical Pulmonary Medicine, Vol: 13, Pages: 263-270
Wilson R, Wickremasinghe M, Ozerovitch LJ, et al., 2006, Authors' reply [3], Thorax, Vol: 61, ISSN: 0040-6376
Wilson R, Wickremasinghe M, Ozerovitch LJ, et al., 2006, Bronchiectasis and non-tuberculous mycobacterial pulmonary infection - Authors' reply, THORAX, Vol: 61, Pages: 458-458, ISSN: 0040-6376
Chung AJ, Deligianni F, Shah P, et al., 2006, Patient-specific bronchoscopy visualization through BRDF estimation and disocclusion correction, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 25, Pages: 503-513, ISSN: 0278-0062
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- Citations: 32
Shah P, 2006, Clinical considerations in lung cancer, Lung Cancer, Pages: 1-11, ISBN: 9780521872027
Introduction Lung cancer remains one of the commonest malignancies, accounting for 20% of all cancers in men with a lifetime risk of 1 in 13 and 12% of all cancers in women with a lifetime <risk of 1 in 23. In the United Kingdom roughly 40,000 new cases are recorded each year. The estimated incidence for lung cancer in males in 2005 in the United States was 92,305 with approximately 91,537 males expected to die from the disease. The risk of lung cancer is about fourfold greater in men than in women and this increases with age: in the European Union the incidence of lung cancer is 7 per 100,000 for men and 3 per 100,000 for women at the age of 35 years, but in patients aged over 75, the rates are 440 and 72 in men and women respectively. Wide geographical variations in the incidence of lung cancer are also reported and this is primarily related to worldwide variations in smoking behaviour. Aetiology Smoking cigarettes is far and away the dominant risk factor in patients with lung cancer, accounting for 90% of lung cancers in men and almost 80% of cases in women. The relationship between smoking and lung cancer mortality was first established by Doll and Hill. In their study, newly admitted patients with suspected lung, liver or bowel cancers were questioned.
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