ProfessorPallavShah

Salaets T, Turner MA, Short M, Ward RM, Hokuto I, Ariagno RL, Klein A, Beauman S, Wade K, Thomson M, Roberts E, Harrison J, Quinn T, Baer G, Davis J, Allegaert K, Allen M, Allen A, Freimane DA, Aschner J, Ballard R, Belew Y, Bax R, Bellflower B, Bhatt-Mehta V, Blum M, Bonardi C, Bondurant P, Boylan G, Buracchio T, Burckart G, Burnett A, Burnham J, Carlson C, Chen A, Clay B, Cohen A, Connolly E, Connor E, Darsey E, De Lisa R, Degl J, Dempsey E, Diacovo T, Dionne J, Duchon J, Eklund W, Fabbri L, Fielder A, Freilich E, Furst-Recktenwald S, Graham T, Green D, Grogan C, Heiselman D, Hellstrom A, Herold R, Hibbs AM, Hirschfeld S, Brown MH, Holberton J, Iveli P, Jobe A, Kayton A, Kenner C, Kraft W, Kusuda S, Lacaze T, Lewis T, Lui K, Lutsar I, Mangili A, Mangum B, McCune S, McDonald K, McGuire C, McPherson C, Miller T, Ming J, Mitzner A, Modi N, Morrison M, Morsing E, Mulugeta L, Nakamura H, Nelson S, Noel G, Olshansky M, Oschman A, Ozsahin H, Padula M, Peiris V, Koplowitz LP, Pham J, Pilon A, Portman R, Pressler R, Rabe H, Raju T, Roepke DA, Savani R, Schnell P, Segal R, Senterre T, Shah P, Sheridan P, Sherwin C, Singh R, Soll R, Soul J, Spence K, Storari L, Taminiau J, Tseng B, Van Den Anker J, Varga J, Venkataraman P, Vivas N, Walker K, Wilson J, Zajicek A, Zaloga G, Zeldis Set al., 2019, Development of a neonatal adverse event severity scale through a Delphi consensus approach, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 104, Pages: 1167-+, ISSN: 0003-9888

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• Citations: 31

Herth FJF, Slebos D-J, Shah PL, Hetzel M, Schmid-Bindert G, LaPrad AS, Deslee G, Valipour Aet al., 2019, Protocol of a Randomized Controlled Study of the PneumRx Endobronchial Coil System versus Standard-of-Care Medical Management in the Treatment of Subjects with Severe Emphysema (ELEVATE), RESPIRATION, Vol: 98, Pages: 512-520, ISSN: 0025-7931

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• Citations: 11

Barnett J, Pulzato I, Burn T, Zafar S, Hine J, Bartlett E, Shah P, Nicholson A, Ridge C, Padley S, Molyneaux P, Kemp S, Devaraj Aet al., 2019, Very Rapid Growth of Small Pulmonary Nodules Predicts Benignity, Publisher: ELSEVIER SCIENCE INC, Pages: S528-S528, ISSN: 1556-0864

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Spiro SG, Shah PL, Rintoul RC, George J, Janes S, Callister M, Novelli M, Shaw P, Kocjan G, Griffiths C, Falzon M, Booton R, Magee N, Peake M, Dhillon P, Sridharan K, Nicholson AG, Padley S, Taylor MN, Ahmed A, Allen J, Ngai Y, Chinyanganya N, Ashford-Turner V, Lewis S, Oukrif D, Rabbitts P, Counsell N, Hackshaw Aet al., 2019, Sequential screening for lung cancer in a high-risk group: randomised controlled trial, European Respiratory Journal, Vol: 54, ISSN: 0903-1936

BACKGROUND: Low-dose computed tomography (LDCT) screening detects early-stage lung cancer and reduces mortality. We proposed a sequential approach targeted to a high-risk group as a potentially efficient screening strategy. METHODS: LungSEARCH was a national multicentre randomised trial. Current/ex-smokers with mild/moderate chronic obstructive pulmonary disease (COPD) were allocated (1:1) to have 5 years surveillance or not. Screened participants provided annual sputum samples for cytology and cytometry, and if abnormal were offered annual LDCT and autofluorescence bronchoscopy (AFB). Those with normal sputum provided annual samples. The primary end-point was the percentage of lung cancers diagnosed at stage I/II (nonsmall cell) or limited disease (small cell). RESULTS: 1568 participants were randomised during 2007-2011 from 10 UK centres. 85.2% of those screened provided an adequate baseline sputum sample. There were 42 lung cancers among 785 screened individuals and 36 lung cancers among 783 controls. 54.8% (23 out of 42) of screened individuals versus 45.2% (14 out of 31) of controls with known staging were diagnosed with early-stage disease (one-sided p=0.24). Relative risk was 1.21 (95% CI 0.75-1.95) or 0.82 (95% CI 0.52-1.31) for early-stage or advanced cancers, respectively. Overall sensitivity for sputum (in those randomised to surveillance) was low (40.5%) with a cumulative false-positive rate (FPR) of 32.8%. 55% of cancers had normal sputum results throughout. Among sputum-positive individuals who had AFB, sensitivity was 45.5% and cumulative FPR was 39.5%; the corresponding measures for those who had LDCT were 100% and 16.1%, respectively. CONCLUSIONS: Our sequential strategy, using sputum cytology/cytometry to select high-risk individuals for AFB and LDCT, did not lead to a clear stage shift and did not improve the efficiency of lung cancer screening.

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Valipour A, Shah PL, Pison C, Ninane V, Janssens W, Perez T, Kessler R, Deslee G, Garner J, Abele C, Hartman JE, Slebos D-J, Chen A, Gorden J, Issa Z, McDonald G, Pulling C, Aalbers R, Ferrera D, Leh L, Firlinger I, Kothakuzhakal K, Duller M, Muylle I, Rummens P, De Cock F, Dooms C, DeBent K, Briault A, Arbib F, Jondot M, Ferretti G, Fournier C, Matran R, Catto M, Bautin N, De Broucker V, Willemin M, Prevotat A, Wemeau L, Gicquello A, Foulon M, Camara H, Vallerand H, Dury S, Gras D, Bonnaire-Verdier M, Hirschi S, Porzio M, Degot T, Canuet M, Schuller A, Stauder J, Azouaou SA, Srikanthan K, Caneja C, Thornton J, Ten Hacken N, Hartman J, Augustijn S, Klooster Ket al., 2019, Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients, RESPIRATION, Vol: 98, Pages: 329-339, ISSN: 0025-7931

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• Citations: 25

Shah PL, 2019, Sonic biopsy: A new tool for the assessment of peripheral pulmonary lesions, RESPIROLOGY, Vol: 24, Pages: 933-934, ISSN: 1323-7799

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Srikanthan K, Kistemaker L, Slebos D-J, Gesierich W, Darwiche K, Bonta P, Deslee G, Shah P, Gosens Ret al., 2019, Targeted Lung Denervation modulates the bronchial epithelial transcriptome in COPD, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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• Citations: 1

Garner J, Orton CM, Caneja C, Sin DD, Shaipanich T, Klooster K, Hartman J, Thornton J, Slebos D-J, Shah PLet al., 2019, Safety and Feasibility of Metered CryoSpray (MCS) for Patients with Chronic Bronchitis in COPD: 9 Month Results, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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• Citations: 4

Goorsenberg AWM, D'Hooghe JNS, Ten Hacken NHT, Weersink EJM, Roelofs JJTH, Srikanthan K, Shah PL, Annema JT, Bonta PIet al., 2019, Bronchial thermoplasty induced reduction of airway smooth muscle: results from the randomized controlled TASMA trial, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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• Citations: 3

Sciurba F, Sue R, Rivas-Perez H, Morrissey B, De Oliveira HG, Wahidi M, Cardoso PFG, Pastis N, Dransfield M, Shah P, Radhakrishnan S, Shargill N, Criner G, Slebos D-Jet al., 2019, Improvements in Clinical Outcomes Associated with Reduction in Hyperinflation with Zephyr Valves, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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Tenda ED, Aboelhassan AM, Kontogianni K, Rice A, Crichton S, Garner JL, Srikanthan K, Nicholson A, Harms A, Herth F, Kemp SV, Eberhardt R, Shah PLet al., 2019, Endobronchial Ultrasound Transbronchial Needle Aspiration (EBUS-TBNA) versus Flexible 19G Endobronchial Ultrasound Transbronchial Needle (Flex 19G EBUS-TBNA) in the Assessment of Mediastinal and Hilar Lymphadenopathy: a Randomised Trial, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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• Citations: 4

Goorsenberg AWM, D'Hooghe JNS, Ten Hacken NHT, Weersink EJM, Bel EH, Shah PL, Annema JT, Bonta PIet al., 2019, Towards optimal patient selection for bronchial thermoplasty treatment in severe asthma: results from the TASMA randomized trial, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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• Citations: 1

Dransfield M, Bhatt S, Slebos D-J, Klooster K, Sciurba F, Shah P, Garner J, Radhakrishnan S, Shargill N, Marchetti N, Criner Get al., 2019, Impact of endobronchial valves on patient reported outcomes in severe emphysema, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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Hartman JE, Klooster K, Augustijn S, Van Geffen WH, Garner J, Shah PL, Ten Hacken NHT, Slebos D-Jet al., 2019, Mechanisms of action of endobronchial coil treatment, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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Valipour A, Shah P, Herth F, Pison C, Schumann C, Huebner R-H, Bonta P, Kessler R, Gesierich W, Darwiche K, Lamprecht B, Perez T, Skowasch D, Deslee G, Marceau A, Sciurba F, Gosens R, Hartman J, Srikanthan K, Duller M, Slebos D-Jet al., 2019, A double-blind, randomized, sham controlled study of Targeted Lung Denervation in patients with moderate to severe COPD Al LOW-2 One Year Outcomes, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

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• Citations: 2

Garner JL, Donovan J, Meireles I, Padley SPG, Cunningham D, Shah PLet al., 2019, A Golden Conundrum, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 200, Pages: 631-632, ISSN: 1073-449X

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Herth FJF, 2019, A Big Applause to Thomas Nold: The Man in the Background Is Retiring, RESPIRATION, Vol: 98, Pages: 281-282, ISSN: 0025-7931

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Herman DD, Thomson CC, Brosnhan S, Patel R, Trosini-Desert V, Bilaceroglu S, Poston JT, Liberman M, Shah PL, Ost DE, Chatterjee R, Michaud GCet al., 2019, Risk of bleeding in patients undergoing pulmonary procedures on antiplatelet or anticoagulants: A systematic review, RESPIRATORY MEDICINE, Vol: 153, Pages: 76-84, ISSN: 0954-6111

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• Citations: 8

Garner JL, Meireles I, Kemp SV, Shah PLet al., 2019, Fiducial marker implantation using convex probe EBUS and autologous blood, BMJ CASE REPORTS, Vol: 12

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• Citations: 2

Conway FM, Garner JL, Orton CM, Srikanthan K, Kemp S, Shah PLet al., 2019, Contemporary Concise Review 2018: Lung cancer and pleural disease, RESPIROLOGY, Vol: 24, Pages: 475-483, ISSN: 1323-7799

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• Citations: 1

Slebos D-J, Cicenia J, Sciurba FC, Criner GJ, Hartman JE, Garner J, Deslee G, Delage A, Jantz M, Marquette C-H, Strange C, Hatipoglu U, Mehta AC, LaPrad AS, Schmid-Bindert G, Herth FJF, Shah PL, Herth FJF, Gompelmann D, Schuhmann M, Eberhardt R, Harzheim D, Rump B, Slebos DJ, Ten Hacken N, Klooster K, Hartman JE, Augustijn S, Shah PL, Caneja C, McNulty W, Garner J, Deslee G, Vallerand H, Dury S, Gras D, Verdier M, Marquette CH, Sanfiorenzo C, Clary C, Leheron C, Pradelli J, Korzeniewski S, Wolter P, Arfi T, Macone F, Poudenx M, Leroy S, Guillemart A, Griffonet J, Strange C, Argula R, Silvestri G, Huggins JT, Pastis N, Woodford D, Schwarz L, Walker D, Criner G, Mamary J, Marchetti N, Desai P, Shenoy K, Garfield JL, Travaline J, Criner H, Srivastava-Malhotra S, Tauch V, Maxfield R, Brenner K, Bulman W, Whippo BA, Jellen PA, Kalhan R, Gillespie CT, Rosenberg S, DeCamp MM, Rogowski AS, Hixon J, Angel LF, Dib O, Sciurba FC, Chandra D, Crespo M, Field JB, Tedrow JR, Ledezma C, Consolaro P, Beckner M, Majid A, Cheng G, Cardenas-Garcia J, Beach D, Folch E, Agnew A, Hori W, Nathanson A, Wahidi M, Shofer S, Hartwig M, Mahmood K, Smathers E, Tillis W, Verma K, Taneja D, Peil M, Chittivelu S, Doloszycki P, Whitten PE, Aulakh B, Ikadios O, Michel J, Crabb J, McVay B, Scott A, Pautler EA, Connolly TA, Santacruz JF, Kopas L, Parham R, Solid B, Krimsky W, Gregoire F, King S, Mehta A, Almeida F, Gildea T, Cicenia J, Machuzak M, Sethi S, Meli YM, Baran J, Rice R, Faile D, Rai N, Jensen K, Kahlstrom R, Haroon A, Ionita R, White F, Watkins D, Moore B, Soukiasian H, Merry H, Mosenifar Z, Ghandehari S, Balfe D, Park J, Mardirosian R, Ferguson JS, Kanne J, Sonetti D, Modi D, Regan M, Maloney J, Hackbarth M, Gilles M, Harris A, Maser A, Puchalski JT, Rochester C, Possick J, Johnson K, Dabre Z, Kovitz K, Joo M, DeLisa J, Villalan SV, Krishna G, Canfield J, Marfatia A, Selley E, Utz J, Midthun D, Kern R, Edell ES, Boras nee Kosok LL, Gay S, Bauman KA, Han MK, Sagana RL, Nelson K, Meldrum Cet al., 2019, Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema, CHEST, Vol: 155, Pages: 928-937, ISSN: 0012-3692

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• Citations: 23

Garner JL, Garner SD, Hardie RJ, Molyneaux PL, Singh S, Kemp SV, Shah PLet al., 2019, Evaluation of a re-useable bronchoscopy biosimulator with ventilated lungs, ERJ Open Research, Vol: 5, ISSN: 2312-0541

Background: Restrictions on respiratory trainee time and access to procedures reduce the opportunities toacquire necessary skills in bronchoscopy. Simulation, not subject to such impediments, is a usefulsupplementary aid to teaching bronchoscopic techniques in a safe environment but there is a limitedchoice of simulators that are sufficiently realistic and not prohibitively expensive. This study evaluated alow-cost device that simulates an intubated and ventilated patient, employing re-useable, inflatable,BioFlex-preserved, porcine lungs.Methods: 26 bronchoscopists, trainee and experienced, after using the bronchoscopy biosimulator,completed a questionnaire using a five-point Likert scale comparing its performance with that of thecomputerised CAE AccuTouch.Results: Participants were largely positive about their experience (mean score of 4.76). The bronchoscopybiosimulator was found to be realistic (mean score 4.64), easy to use (mean score 4.88), and helpful inlearning to perform a variety of diagnostic and therapeutic procedures (mean score 4.85). Importantly, thebronchoscopy biosimulator compared favourably to the computer simulator (mean score 4.84).Conclusions: These data support the concept of the bronchoscopy biosimulator as an acceptable modelwith which to supplement the experience of bronchoscopic procedures.

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van Geffen WH, Slebos D-J, Herth FJ, Kemp S, Weder W, Shah PLet al., 2019, Surgical and endoscopic interventions that reduce lung volume for emphysema: a systemic review and meta-analysis, LANCET RESPIRATORY MEDICINE, Vol: 7, Pages: 313-324, ISSN: 2213-2600

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• Citations: 69

d'Hooghe JNS, Goorsenberg AWM, ten Hacken NHT, Weersink EJM, Roelofs JJTH, Mauad T, Shah PL, Annema JT, Bonta PI, Srikanthan K, Caneja C, Garner J, Hartman J, Klooster K, Koning KJ, Vander Pol M, Hallmann C, Lone-Latif S, de Boer O, Slebos DJet al., 2019, Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV₁, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 49, Pages: 541-544, ISSN: 0954-7894

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• Citations: 13

Shen M, Tenda ED, McNulty W, Garner J, Robbie H, Luzzi V, Aboelhassan AM, Van Geffen WH, Kemp SV, Ridge C, Devaraj A, Shah PL, Yang G-Zet al., 2019, Quantitative Evaluation of Lobar Pulmonary Function of Emphysema Patients with Endobronchial Coils, RESPIRATION, Vol: 98, Pages: 70-81, ISSN: 0025-7931

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• Citations: 9

Herth FJF, 2019, A Big Applause to Thomas Nold: The Man in the Background Is Retiring., Respiration, Vol: 98, Pages: 281-282

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Dransfield MT, Bhatt SP, Slebos D, Klooster K, Sciurba FC, Shah PL, Garner J, Radhakkrishnan S, Shargill NS, Marchetti N, Criner Get al., 2019, Impact of Zephyr Endobronchial Valves on Patient Reported Outcomes, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

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Shah PL, 2019, Anatomy of the respiratory system, RESPIRATORY MEDICINE, 3RD EDITION, Editors: Palange, Rohde, Publisher: EUROPEAN RESPIRATORY SOCIETY, Pages: 1-6, ISBN: 978-1-84984-079-8

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Garner J, Garner S, Hardie R, Meireles I, Caneja C, Tenda ED, Srikanthan K, Orton C, Aboelhassan A, Finney L, Wiseman D, Molyneaux PL, Loebinger MR, Hopkinson NS, Kemp S, Shah PLet al., 2019, Evaluation of a Low Cost, Re-Useable, Bronchoscopy Biosimulator with Ventilated Lungs: The Bronchoscopy BioSim, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

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Tenda ED, Ridge CA, Shen M, Yang G-Z, Shah PLet al., 2019, Role of Quantitative Computed Tomographic Scan Analysis in Lung Volume Reduction for Emphysema, RESPIRATION, Vol: 98, Pages: 86-94, ISSN: 0025-7931

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• Citations: 8