Publications
280 results found
Piccini P, 2013, IMAGING OF ACTIVATED MICROGLIA IN HUNTINGTON'S DISEASE, 11th European Meeting on Glial Cell Function in Health and Disease, Publisher: WILEY-BLACKWELL, Pages: S33-S33, ISSN: 0894-1491
Roussakis, Politis M, Piccini P, 2013, Clinical utility of DaTscan™ (123I-ioflupane injection) in the diagnosis of Parkinsonian syndromes, Degenerative Neurological and Neuromuscular Disease, Vol: 3, Pages: 33-39, ISSN: 1179-9900
Barker RA, Mason SL, Harrower TP, et al., 2013, The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, Pages: 657-665, ISSN: 0022-3050
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- Citations: 74
Giannetti P, Politis M, Su P, et al., 2013, Microglia Activation in Clinically Isolated Syndrome: 11C11195PK-PET Change within Normal Appearing White Matter and Deep Grey Matter Structures, 65th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Politis M, Loane C, Pavese N, et al., 2013, Sustained and Prolonged Striatal Dopamine Levels in Parkinson's Patients Following Enteral L-Dopa Gel Infusion: An In Vivo 11C-Raclopride PET Study, 65th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Niccolini F, Giannetti P, Politis M, et al., 2013, In Vivo Detection of Thalamo-Cortical Pathology in Patients with Clinical Isolated Syndrome, 65th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Politis M, Giannetti P, Niccolini F, et al., 2013, Decreased Microglial Activation Precedes Stabilization of Disability in Multiple Sclerosis Patients Treated with Natalizumab, 65th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Politis M, Loane C, Wu K, et al., 2013, Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease, BRAIN, Vol: 136, Pages: 400-411, ISSN: 0006-8950
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- Citations: 117
O'Sullivan SS, Wu K, Politis M, et al., 2013, Erratum: Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours (Brain (2011) 134 (969-978) DOI: 10.1093/brain/awr003), Brain, Vol: 136, ISSN: 0006-8950
Loane C, Wu K, Bain P, et al., 2013, Serotonergic loss in motor circuitries correlates with severity of tremor in PD, Annals of Neurology
Clark L, Stokes PR, Wu K, et al., 2012, Striatal dopamine D<sub>2</sub>/D<sub>3</sub> receptor binding in pathological gambling is correlated with mood-related impulsivity, NEUROIMAGE, Vol: 63, Pages: 40-46, ISSN: 1053-8119
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- Citations: 109
Politis M, Piccini P, 2012, Positron emission tomography imaging in neurological disorders, JOURNAL OF NEUROLOGY, Vol: 259, Pages: 1769-1780, ISSN: 0340-5354
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- Citations: 59
Ruffmann C, Bravi I, Calboli FCF, et al., 2012, Dementia in Lewy body disorders: clinicopathological correlations in a large sample from the Parkinson's UK Tissue Bank, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 72-72, ISSN: 1351-5101
Wu K, Politis M, Piccini P, 2012, Impulse control disorders in parkinson's disease: A review, Current Psychiatry Reviews, Vol: 8, Pages: 235-246, ISSN: 1573-4005
The development of Impulse Control Disorders (ICDs) in Parkinson's disease (PD) is a recognised iatrogenic complication associated with the use of dopamine agonists. The prevalence of ICDs has been reported to be as high as 14% in studies conducted in Europe and North America. Early case reports and recent large-scale studies have shown that clinical features associated with the development of PD-related ICDs include novelty-seeking personality traits, early onset PD and a past history of psychiatric conditions. More recent studies have also suggested that ICDs may be associated with deep brain stimulation and dyskinesias. Moreover, there is heterogeneity in the clinical features associated with the range of ICDs, with studies pointing out that compulsive sexual behaviours and binge eating have fewer clinical features in common than compulsive buying and pathological gambling. The recent increase in the number of functional neuroimaging studies on patients with PD and ICDs, particularly those with pathological gambling, has provided a unique opportunity to understand the neurobiology of the disorder, and has indicated an abnormality in the meso-limbic dopaminergic pathways. Further studies directly comparing ICD sufferers with and without PD will provide valuable knowledge to aid in the management of both patient groups. This review will provide a clinical overview of impulse control behaviours in PD, including both commonly reported ICDs and other related impulsive-compulsive behaviours observed in PD. © 2012 Bentham Science Publishers.
Politis M, Giannetti P, Su P, et al., 2012, Increased PK11195 PET binding in the cortex of patients with MS correlates with disability, NEUROLOGY, Vol: 79, Pages: 523-530, ISSN: 0028-3878
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- Citations: 131
Colasanti A, Guo Q, Onega M, et al., 2012, [<SUP>18</SUP>F]PBR111 binding in multiple sclerosis: relationship to age and clinical variables, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S22-S22, ISSN: 0271-678X
Wu K, O'Keeffe D, Politis M, et al., 2012, The catechol-O-methyltransferase Val<SUP>158</SUP>Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study, BRAIN, Vol: 135, Pages: 2449-2457, ISSN: 0006-8950
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- Citations: 47
Politis M, Wu K, Loane C, et al., 2012, Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson's Patients Treated with Dopamine Grafts, SCIENCE TRANSLATIONAL MEDICINE, Vol: 4, ISSN: 1946-6234
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- Citations: 92
Wu K, O'Keeffe D, Politis M, et al., 2012, IN VIVO EVIDENCE OF COMT VAL158MET FUNCTIONAL POLYMORPHISM MODULATES DIFFERENT LEVELS OF DOPAMINE TURNOVER IN PARKINSON'S DISEASE: AN 18F-DOPA PET STUDY, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, ISSN: 0022-3050
Giannetti P, Politis M, Su P, et al., 2012, PK11195-PET Enhancement in Black Holes Correlates with Disability and Outcome in Progressive Multiple Sclerosis, 137th Annual Meeting of the American-Neurological-Association (ANA), Publisher: WILEY-BLACKWELL, Pages: S112-S112, ISSN: 0364-5134
Politis M, Piccini P, 2012, <i>In vivo</i> imaging of the integration and function of nigral grafts in clinical trials, FUNCTIONAL NEURAL TRANSPLANTATION III PRIMARY AND STEM CELL THERAPIES FOR BRAIN REPAIR, PT I, Vol: 200, Pages: 199-220, ISSN: 0079-6123
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- Citations: 15
Politis M, Su P, Piccini P, 2012, Imaging of microglia in patients with neurodegenerative disorders, FRONTIERS IN PHARMACOLOGY, Vol: 3, ISSN: 1663-9812
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- Citations: 82
Piccini P, Politis M, 2011, Cell-Based Therapies, Imaging in Parkinson's Disease, ISBN: 9780195393484
This chapter discusses recent advances in the field of cell therapy for Parkinson's disease and the utilization of functional imaging to monitor survival and growth of grafted human embryonic dopamine cells. Additionally, studies of long-term treatment outcome are reviewed, including the potential application of preoperative imaging for the selection of transplantation candidates. The chapter also provides valuable new data on imaging changes underlying complications of therapy such as graft-related dyskinesias. Additional data are provided on the use of novel PET tracers to assess the role of serotonergic terminals in grafted tissue as well as MRI methods to evaluate changes in neural circuitry following cell implantation.
Politis M, Oertel WH, Wu K, et al., 2011, Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio, MOVEMENT DISORDERS, Vol: 26, Pages: 1997-2003, ISSN: 0885-3185
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- Citations: 124
Politis M, Loane C, Wu K, et al., 2011, Serotonergic mediated body mass index changes in Parkinson's disease, NEUROBIOLOGY OF DISEASE, Vol: 43, Pages: 609-615, ISSN: 0969-9961
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- Citations: 36
Stokes PR, Clark L, Wu K, et al., 2011, IMAGING THE DOPAMINE SYSTEM IN PATHOLOGICAL GAMBLING: AN [11C]-RACLOPRIDE PET STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A61-A61, ISSN: 0269-8811
O'Sullivan SS, Loane CM, Lawrence AD, et al., 2011, Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 82, Pages: 620-622, ISSN: 0022-3050
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- Citations: 24
Meissner WG, Frasier M, Gasser T, et al., 2011, Priorities in Parkinson's disease research, NATURE REVIEWS DRUG DISCOVERY, Vol: 10, Pages: 377-393, ISSN: 1474-1776
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- Citations: 328
Giannetti P, Politis M, Su P, et al., 2011, Two different roles for microglia in vivo in T1 black holes in relapsing and progressive multiple sclerosis?, 21st Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: 221-221, ISSN: 0340-5354
O'Sullivan SS, Wu K, Politis M, et al., 2011, Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours, BRAIN, Vol: 134, Pages: 969-978, ISSN: 0006-8950
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- Citations: 203
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