Publications
280 results found
Owen DRJ, Piccini P, Matthews PM, 2011, Towards molecular imaging of multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 262-272, ISSN: 1352-4585
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- Citations: 7
Tai YF, Hoshi R, Brignell CM, et al., 2011, Persistent Nigrostriatal Dopaminergic Abnormalities in Ex-Users of MDMA ('Ecstasy'): An <SUP>18</SUP>F-Dopa PET Study, NEUROPSYCHOPHARMACOLOGY, Vol: 36, Pages: 735-743, ISSN: 0893-133X
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- Citations: 18
Politis M, Pavese N, Tai YF, et al., 2011, Microglial activation in regions related to cognitive function predicts disease onset in Huntington's Disease: A multimodal imaging study, HUMAN BRAIN MAPPING, Vol: 32, Pages: 258-270, ISSN: 1065-9471
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- Citations: 147
Kiferle L, Politis M, Muraro PA, et al., 2011, Positron emission tomography imaging in multiple sclerosis-current status and future applications, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 18, Pages: 226-231, ISSN: 1351-5101
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- Citations: 25
Politis M, Wu K, Loane C, et al., 2010, Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures, NEUROLOGY, Vol: 75, Pages: 1920-1927, ISSN: 0028-3878
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- Citations: 155
Wu K, O'Sullian S, Politis M, et al., 2010, REWARDING VISUAL CUES INCREASE DOPAMINE NEUROTRANSMISSION IN PARKINSON'S PATIENTS WITH IMPULSE CONTROL DISORDERS: A PET STUDY, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: E29-E30, ISSN: 0022-3050
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- Citations: 6
Politis M, Wu K, Loane C, et al., 2010, Staging of serotonergic dysfunction in Parkinson's Disease: An <i>in vivo</i> <SUP>11</SUP>C-DASB PET study, NEUROBIOLOGY OF DISEASE, Vol: 40, Pages: 216-221, ISSN: 0969-9961
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- Citations: 183
Wu K, Politis M, O'Sullivan S, et al., 2010, Impulse Control Disorders Subtypes in Parkinson's Disease: Clinical and PET Correlations, MOVEMENT DISORDERS, Vol: 25, Pages: S725-S726, ISSN: 0885-3185
Wu K, Politis M, Warsi S, et al., 2010, Measuring Severity of Impulse Control Disorders in Parkinson's Disease Using Objective Validated Questionnaire, MOVEMENT DISORDERS, Vol: 25, Pages: S683-S684, ISSN: 0885-3185
Politis M, Wu K, Molloy S, et al., 2010, Parkinson's Disease Symptoms: The Patient's Perspective, MOVEMENT DISORDERS, Vol: 25, Pages: 1646-1651, ISSN: 0885-3185
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- Citations: 353
Politis M, Wu K, Loane C, et al., 2010, Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants., Sci Transl Med, Vol: 2, ISSN: 1946-6242
Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of cell-based therapies for Parkinson's disease. The mechanisms underlying these dyskinesias are not well understood, and it is not known whether they are the same as in the dyskinesias induced by l-dopa treatment. Using in vivo brain imaging, we show excessive serotonergic innervation in the grafted striatum of two patients with Parkinson's disease, who had exhibited major motor recovery after transplantation with dopamine-rich fetal mesencephalic tissue but had later developed off-medication dyskinesias. The dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-HT)] receptor (5-HT(1A)) agonist, which dampens transmitter release from serotonergic neurons, indicating that the dyskinesias were caused by the serotonergic hyperinnervation. Our observations suggest strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease with fetal tissue or stem cells.
O'Sullivan SS, Loane C, Lawrence AD, et al., 2010, Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease., J Neurol Neurosurg Psychiatry
Politis M, Giannetti P, Su P, et al., 2010, Cortical Microglial Activation Is Associated with Disability in Secondary Progressive Multiple Sclerosis: An <i>In Vivo</i> Imaging Study, 62nd Annual Meeting of the American-Academy-of-Neurology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A290-A290, ISSN: 0028-3878
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- Citations: 4
Pavese N, Moore RY, Scherfler C, et al., 2010, In vivo assessment of brain monoamine systems in <i>parkin</i> gene carriers: A PET study, EXPERIMENTAL NEUROLOGY, Vol: 222, Pages: 120-124, ISSN: 0014-4886
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- Citations: 22
Pavese N, Politis M, Tai YF, et al., 2010, Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers, NEUROBIOLOGY OF DISEASE, Vol: 37, Pages: 356-361, ISSN: 0969-9961
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- Citations: 44
Bjorklund A, Cenci MA, 2010, Brain imaging after neural transplantation, RECENT ADVANCES IN PARKINSONS DISEASE: TRANSLATIONAL AND CLINICAL RESEARCH, Vol: 184, Pages: 193-203, ISSN: 0079-6123
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- Citations: 14
Bonuccelli U, Piccini P, Rabey JM, 2009, Proceedings of the LIMPE Seminar, 26-28 February, Pisa, Italy, 2009 "Old and New Dopamine Agonists in Parkinson's Disease: a Reappraisal" Introduction, International Conference on Seneca Philosophus, Publisher: ELSEVIER SCI LTD, Pages: S1-S1, ISSN: 1353-8020
Bonuccelli U, Piccini P, Rabey JM, 2009, Old and new dopamine agonists in Parkinson's disease: a reappraisal. Introduction., Parkinsonism Relat Disord, Vol: 15 Suppl 4
Pavese N, Kiferle L, Piccini P, 2009, Neuroprotection and imaging studies in Parkinson's disease, PARKINSONISM & RELATED DISORDERS, Vol: 15, Pages: S33-S37, ISSN: 1353-8020
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- Citations: 13
Pavese N, Khan NL, Scherfler C, et al., 2009, Nigrostriatal Dysfunction in Homozygous and Heterozygous <i>Parkin</i> Gene Carriers: An <SUP>18</SUP>F-Dopa PET Progression Study, MOVEMENT DISORDERS, Vol: 24, Pages: 2260-2266, ISSN: 0885-3185
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- Citations: 36
Wu K, Politis M, Piccini P, 2009, Parkinson disease and impulse control disorders: a review of clinical features, pathophysiology and management, POSTGRADUATE MEDICAL JOURNAL, Vol: 85, Pages: 590-596, ISSN: 0032-5473
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- Citations: 49
Politis M, Piccini P, Pavese N, et al., 2008, Evidence of dopamine dysfunction in the hypothalamus of patients with Parkinson's disease: An <i>in vivo</i> <SUP>11</SUP>C-raclopride PET study, EXPERIMENTAL NEUROLOGY, Vol: 214, Pages: 112-116, ISSN: 0014-4886
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- Citations: 85
Politis M, Pavese N, Tai YF, et al., 2008, Hypothalamic involvement in Huntingtons disease: an <i>in vivo</i> PET study, BRAIN, Vol: 131, Pages: 2860-2869, ISSN: 0006-8950
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- Citations: 131
Reuter I, Tai YF, Pavese N, et al., 2008, Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 79, Pages: 948-951, ISSN: 0022-3050
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- Citations: 88
Piccini P, 2008, Visualizing new therapeutic concepts in PD - application of PET in cell-based therapy, 12th Congress of the European-Federation-of-Neurological-Societies, Publisher: WILEY-BLACKWELL, Pages: 393-394, ISSN: 1351-5101
Sawamoto N, Piccini P, Hotton G, et al., 2008, Cognitive deficits and striato-frontal dopamine release in Parkinson's disease, BRAIN, Vol: 131, Pages: 1294-1302, ISSN: 0006-8950
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- Citations: 199
Turkheimer FE, Boussion N, Anderson AN, et al., 2008, PET image denoising using a synergistic multiresolution analysis of structural (MRI/CT) and functional datasets, JOURNAL OF NUCLEAR MEDICINE, Vol: 49, Pages: 657-666, ISSN: 0161-5505
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- Citations: 40
Pavese N, Khan NL, Wood NW, et al., 2008, Nigrostriatal dysfunction in parkin linked parkinsonism and asymptomatic heterozygous carriers: A progressive study with 18-dopa pet, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 341-341, ISSN: 0022-3050
Hoshi R, Mullins K, Boundy C, et al., 2007, Neurocognitive function in current and ex-users of ecstasy in comparison to both matched polydrug-using controls and drug-naive controls, PSYCHOPHARMACOLOGY, Vol: 194, Pages: 371-379, ISSN: 0033-3158
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- Citations: 32
Hoshi R, Cohen L, Lemanski L, et al., 2007, Ecstasy (MDMA) does not have long-term effects on aggressive interpretative bias: A study comparing current and ex-ecstasy users with polydrug and drug-naive controls, EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, Vol: 15, Pages: 351-358, ISSN: 1064-1297
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- Citations: 11
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