Imperial College London
Portrait Picture

ProfessorPaolaPiccini

Faculty of Medicine, Department of Brain Sciences

Emeritus Professor - Neurology
 
 
 
//

Contact

 

+44 (0)20 3313 3773paola.piccini

 
 
//

Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
//

Location

 

U107BBlock B Hammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Roussakis:2019,
author = {Roussakis, A and Gennaro, M and Lao-Kaim, N and Towey, D and Piccini, P},
journal = {Journal of Neuroinflammation and Neurodegenerative Diseases},
title = {Dopamine transporter density in de novo Parkinson’s disease does not relate to the development of levodopa-induced dyskinesias},
url = {http://hdl.handle.net/10044/1/70693},
volume = {3},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: In Parkinson’s disease (PD), the onset of levodopa-induced dyskinesias (LIDs) is difficult to predict. This study examines whether dopamine transporter (DAT)-specific SPECT imaging in de novo PD relates to later development of LIDs.Methods: 42 de novo unilateral PD participants received DAT-specific SPECT imaging with 123I-FP-CIT at time of diagnosis. At five years post-diagnosis, all PD patients were clinically evaluated and divided into two groups based on whether they had or had not developed LIDs. Fourteen gender- and age-matched healthy volunteers undertook 123I-FP-CIT SPECT imaging and were included as controls. A semi-quantification approach was used for the 123I-FP-CIT data using the occipital cortex as the reference region. We calculated specific binding ratios (SBR) for the caudate and putamen (posterior and anterior putaminal subregions). In parallel, we analysed our 123I-FP-CIT dataset with a voxel-based analysis approach.Results: PD patients had significantly lower striatal 123I-FP-CIT SBR values in comparison to controls (p<0.001). After five years, dyskinetic patients (N=10) were taking higher daily doses of dopaminergic medication (p<0.001) and had more severe disease (difference in Hoehn & Yahr staging scores p<0.05) as compared to the nondyskinetic group (N=32). At the time of diagnosis, 123I-FP-CIT SBR values were not statistically different between the two groups for all striatal regions (p>0.05). SPM voxel-based analysis did not show a statistically significant difference between the two groups (p>0.05).Conclusion: 123I-FP-CIT SPECT imaging, performed at diagnosis in de novo early-stage PD could not differentiate patients who will develop LIDs within five years from those who will not.
AU  - Roussakis,A
AU  - Gennaro,M
AU  - Lao-Kaim,N
AU  - Towey,D
AU  - Piccini,P
PY  - 2019///
TI  - Dopamine transporter density in de novo Parkinson’s disease does not relate to the development of levodopa-induced dyskinesias
T2  - Journal of Neuroinflammation and Neurodegenerative Diseases
UR  - http://hdl.handle.net/10044/1/70693
VL  - 3
ER  -
Download