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@article{Li:2020:10.1016/j.nicl.2020.102409,
author = {Li, W and Lao-Kaim, NP and Roussakis, A-A and Martin-Bastida, A and Valle-Guzman, N and Paul, G and Soreq, E and Daws, RE and Foltynie, T and Barker, RA and Hampshire, A and Piccini, P},
doi = {10.1016/j.nicl.2020.102409},
journal = {NeuroImage: Clinical},
pages = {1--10},
title = {Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson's disease},
url = {http://dx.doi.org/10.1016/j.nicl.2020.102409},
volume = {28},
year = {2020}
}

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TY  - JOUR
AB  - BackgroundResting-state functional magnetic resonance imaging (fMRI) studies have demonstrated that basal ganglia functional connectivity is altered in Parkinson’s disease (PD) as compared to healthy controls. However, such functional connectivity alterations have not been related to the dopaminergic deficits that occurs in PD over time.ObjectivesTo examine whether functional connectivity impairments are correlated with dopaminergic deficits across basal ganglia subdivisions in patients with PD both cross-sectionally and longitudinally.MethodsWe assessed resting-state functional connectivity of basal ganglia subdivisions and dopamine transporter density using 11C-PE2I PET in thirty-four PD patients at baseline. Of these, twenty PD patients were rescanned after 19.9 ± 3.8 months. A seed-based approach was used to analyze resting-state fMRI data. 11C-PE2I binding potential (BPND) was calculated for each participant. PD patients were assessed for disease severity.ResultsAt baseline, PD patients with greater dopaminergic deficits, as measured with 11C-PE2I PET, showed larger decreases in posterior putamen functional connectivity with the midbrain and pallidum. Reduced functional connectivity of the posterior putamen with the thalamus, midbrain, supplementary motor area and sensorimotor cortex over time were significantly associated with changes in DAT density over the same period. Furthermore, increased motor disability was associated with lower intraregional functional connectivity of the posterior putamen.ConclusionsOur findings suggest that basal ganglia functional connectivity is related to integrity of dopaminergic system in patients with PD. Application of resting-state fMRI in a large cohort and longitudinal scanning may be a powerful tool for assessing underlying PD pathology and its progression.
AU  - Li,W
AU  - Lao-Kaim,NP
AU  - Roussakis,A-A
AU  - Martin-Bastida,A
AU  - Valle-Guzman,N
AU  - Paul,G
AU  - Soreq,E
AU  - Daws,RE
AU  - Foltynie,T
AU  - Barker,RA
AU  - Hampshire,A
AU  - Piccini,P
DO  - 10.1016/j.nicl.2020.102409
EP  - 10
PY  - 2020///
SN  - 2213-1582
SP  - 1
TI  - Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson's disease
T2  - NeuroImage: Clinical
UR  - http://dx.doi.org/10.1016/j.nicl.2020.102409
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000600619100052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S2213158220302461?via%3Dihub
UR  - http://hdl.handle.net/10044/1/103321
VL  - 28
ER  -

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