Imperial College London
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ProfessorPaolaPiccini

Faculty of Medicine, Department of Brain Sciences

Emeritus Professor - Neurology
 
 
 
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Contact

 

+44 (0)20 3313 3773paola.piccini

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U107BBlock B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mohamed:2022:braincomms/fcac199,
author = {Mohamed, MA and Zeng, Z and Gennaro, M and Lao-Kaim, N and Myers, J and Calsolaro, V and Femminella, G and Tyacke, R and Martin-Bastida, A and Gunn, R and Nutt, D and Edison, P and Piccini, P and Roussakis, A},
doi = {braincomms/fcac199},
journal = {Brain Communications},
title = {Astrogliosis in aging and Parkinson’s disease dementia: a new clinical study with 11C-BU99008 PET},
url = {http://dx.doi.org/10.1093/braincomms/fcac199},
volume = {4},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites (I2BS) represent a possible target to map the distribution of reactive astrocytes. In this study, we use 11C-BU99008, an I2BS-specific PET radioligand, to image reactive astrocytes in vivo in healthy controls (HCs) andpatients with established Parkinson’s disease dementia (PDD).Eighteen HCs (age: 45−78 years) and six patients with PDD (age: 64−77 years) had one 11C-BU99008 PET-CT scan with arterial input function. All subjects underwent one 3T MRI brain scan to facilitate the analysis of the PET-CT data and to capture individual cerebral atrophy. Regional 11C-BU99008 volumes of distribution (VT) were calculated for each subject by two-tissue compartmental modelling.Positive correlations between 11C-BU99008 VT values and age were found for all tested regions across the brain within HCs (p<0.05); furthermore, multiple regression indicated that aging affects 11C-BU99008 VT values in a region-specific manner. Independent samples t-test indicated that there was no significant group difference in 11C-BU99008 VT values betweenPDD (n=6; mean age = 71.97±4.66 years) and older HCs (n=9; mean age = 71.90±5.51 years).Our dataset shows that astrogliosis is common with aging in a region-specific manner. However, in this set-up, 11C-BU99008 PET cannot differentiate patients with PDD from healthy controls of similar age.
AU  - Mohamed,MA
AU  - Zeng,Z
AU  - Gennaro,M
AU  - Lao-Kaim,N
AU  - Myers,J
AU  - Calsolaro,V
AU  - Femminella,G
AU  - Tyacke,R
AU  - Martin-Bastida,A
AU  - Gunn,R
AU  - Nutt,D
AU  - Edison,P
AU  - Piccini,P
AU  - Roussakis,A
DO  - braincomms/fcac199
PY  - 2022///
SN  - 2632-1297
TI  - Astrogliosis in aging and Parkinson’s disease dementia: a new clinical study with 11C-BU99008 PET
T2  - Brain Communications
UR  - http://dx.doi.org/10.1093/braincomms/fcac199
UR  - http://hdl.handle.net/10044/1/97901
VL  - 4
ER  -
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