Imperial College London
Alternate

Dr Paras Anand

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2063paras.anand Website

 
 
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Location

 

8.N23Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Olona:2022:10.1016/j.it.2022.10.003,
author = {Olona, A and Leishman, S and Anand, P},
doi = {10.1016/j.it.2022.10.003},
journal = {Trends in Immunology},
pages = {978--989},
title = {The NLRP3 inflammasome: Regulation by metabolic signals},
url = {http://dx.doi.org/10.1016/j.it.2022.10.003},
volume = {43},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Macrophages undergo profound metabolic reprogramming upon sensing infectious and sterile stimuli. This metabolic shift supports and regulates essential innate immune functions, including activation of the NLRP3 inflammasome. Within distinct metabolic networks, key enzymes play pivotal roles to control flux restraining detrimental inflammasome signaling. However, depending on the metabolic cues, specific enzymes and metabolites result in inflammasome activation outcomes which contrast other metabolic steps in the pathway. We posit that understanding which metabolic steps commit to discrete inflammasome fates will broaden our understanding of metabolic checkpoints to maintain homeostasis and offer better therapeutic options in human disease.
AU  - Olona,A
AU  - Leishman,S
AU  - Anand,P
DO  - 10.1016/j.it.2022.10.003
EP  - 989
PY  - 2022///
SN  - 0167-5699
SP  - 978
TI  - The NLRP3 inflammasome: Regulation by metabolic signals
T2  - Trends in Immunology
UR  - http://dx.doi.org/10.1016/j.it.2022.10.003
UR  - http://hdl.handle.net/10044/1/100791
VL  - 43
ER  -
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