Imperial College London
Alternate

Dr Paras Anand

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2063paras.anand Website

 
 
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Location

 

8.N23Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Anand:2010:10.4161/cib.3.5.12474,
author = {Anand, PK},
doi = {10.4161/cib.3.5.12474},
journal = {Commun Integr Biol},
pages = {405--408},
title = {Exosomal membrane molecules are potent immune response modulators.},
url = {http://dx.doi.org/10.4161/cib.3.5.12474},
volume = {3},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Exosomes are endosome-derived vesicles (40-100 nm) formed during the formation of multi-vesicular bodies (MVBs). Occasionally, the MVBs fuse with the plasma membrane releasing their intra-luminal vesicles into the extracellular media, which are then known as exosomes. Different cell types such as B-cells, dendritic cells, platelets, reticulocytes and macrophages can release exosomes and current research in this area is more focused towards exosomes released by antigen-presenting cells. Exosomes have recently been shown to be immunomodulatory and the mechanism of immune response initiation by them is beginning to emerge. Besides molecules present inside the lumen of exosomes, it has been suggested that certain exosomal membrane molecules can interact with their surface receptors on the target cells thereby inducing an immunomodulatory response. In this review, Hsp70 and galectin-5, two immunogenic molecules present on exosomal membrane, are discussed in detail for initiating this response.
AU  - Anand,PK
DO  - 10.4161/cib.3.5.12474
EP  - 408
PY  - 2010///
SP  - 405
TI  - Exosomal membrane molecules are potent immune response modulators.
T2  - Commun Integr Biol
UR  - http://dx.doi.org/10.4161/cib.3.5.12474
UR  - https://www.ncbi.nlm.nih.gov/pubmed/21057626
VL  - 3
ER  -
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